Soft tissue mineralization: Roentgen analysis

Feldman, Frieda

doi:10.1016/0363-0188(86)90003-4

Cited by 12 publications

(7 citation statements)

References 90 publications

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“…However, certain limitations do exist: (1) they are artificial systems that may create unphysiologically high local concentrations of osteogenic factors in implanted sites leading to effects not relevant to the human disorder, (2) the implantation is a local event and thus has limited ability to mimic the potential effects of the involvement of multiple systems, (3) different variations of this method have variable reliabilities and relevance to human conditions, (4) the incidence of implantation-induced bone formation varies depending upon the material or animal species. Normally rabbits are the most, and mice the least, susceptible [78], and experimental conditions that produce ectopic bone do not always coincide with clinical observations in humans.…”

Section: Animal Models For Acquired Homentioning

confidence: 99%

Animal Models of Typical Heterotopic Ossification

Kan

Kessler

2010

BioMed Research International

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Heterotopic ossification (HO) is the formation of marrow-containing bone outside of the normal skeleton. Acquired HO following traumatic events is a common and costly clinical complication. In contrast, hereditary HO is rarer, progressive, and life-threatening. Substantial effort has been directed towards understanding the mechanisms underlying HO and finding efficient treatments. However, one crucial limiting factor has been the lack of relevant animal models. This article reviews the major currently available animal models, summarizes some of the insights gained from these studies, and discusses the potential future challenges and directions in HO research.

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Section: Animal Models For Acquired Homentioning

confidence: 99%

Animal Models of Typical Heterotopic Ossification

Kan

Kessler

2010

BioMed Research International

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“…Genel olarak travma HO insidans›n› ar-t›r›r (6). HO vakalar›nda; travma, yan›k, cerrahi müdahale, nörolojik duruma sekonder immobilite tetikleyici çevresel faktörleri olufltururlar (7). Genetik predispozan faktörlerden flüphelenilmifltir.…”

Section: Tartifimaunclassified

“…fiiddetli TBY'l› hastalar›n %11-76's›nda HO görülür. Bafll›ca üst ve alt ekstremitenin proksimal eklemlerini tutar (7,11). TBY'l› hastalarda en s›k tutulum yerinin kalça, dirsek, ve omuz böl- gesi oldu¤u görülmüfltür (4,6).…”

Section: Tartifimaunclassified

“…Yan›k sonras› nadir olarak HO görülebilir (15,16,17,18). Nörolojik defisitli hastalar›n s›kl›kla proksimal eklemleri tutulurken (13), yan›k sonras› en s›k olarak dirseklerde görülür ve ya-n›k yerleriyle iliflkisiz olarak geliflir (7) .…”

Section: Tartifimaunclassified

“…Bakker ve ark (26) konjenital bilateral facial paralizili bir hastada, temporal kas transpozisyonunu takiben HO geliflti¤ini bildirmifllerdir. HO vakalar›nda; travma, yan›k, cerrahi müdahale, nörolojik duruma sekonder immobilite tetikleyici çevresel faktörleri olufltururlar (7). Hastam›zda HO'na neden olabilecek bilinen bir hastal›k olmamakla birlikte, Myastenia Gravis nedeniyle 1 y›l süreyle tam immobilizasyon vard›.…”

Section: Tartifimaunclassified

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Heterotopic ossification in the myasthenia gravis: A case report

Balcı

Samancı

Oğuz

2005

BMR

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Heterotopik ossifikasyon, eklem çevresinde yeni kemik oluflumudur. Klinik önemi, potansiyel eklem hareket aral›¤› kayb› olmas›d›r. Genellikle kafa travmas›, medulla spinalis yaralanmas›, yan›k veya direkt kas dokusu travmas› olan hastalarda görülür. Bu çal›flmada kalça eklemlerinin hareket aral›¤›nda k›s›tl›l›k geliflen Myastenia Gravis'li 39 yafl›nda bir hasta sunuldu. Radyografi ve bilgisayarl› tomografide bilateral kalça eklemi etraf›nda yeni kemik oldu¤u gösterildi. Literatürde Myastenia Gravis'de heterotopik ossifikasyon saptanan ilk vakad›r. Muhtemelen kas paralizisinden dolay› uzun süreli total immobilizasyon hastada heterotopik ossifikasyon geliflmesinin nedeni olabilir.

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