Soft-tissue masses as presentation of non-Hodgkin's lymphoma in AIDS patients

Abstract

Primary soft tissue Non-Hodgkin lymphomas are very rare and account only for 0.1 % of the cases. Generally, Non-Hodgkin lymphomas of the soft tissue present as large subcutaneous masses without evidence of nodal or skin involvement. We describe four cases of primary Non-Hodgkin lymphomas of the soft tissue in patients infected with the human immunodeficiency virus. The most common site of involvement was the chest wall in all the patients; histopathological and immunophenotypic examination of the biopsy smears revealed two cases of plasmablastic lymphomas, one Burkitt and one diffuse large B-cell lymphoma. Non-Hodgkin lymphomas should be included in the differential diagnosis of soft tissue masses in human immunodeficiency virus - seropositive patients.

Large abdominal mass as clinical presentation of plasmablastic lymphoma

“…[1] in 1987 arising, generally, in the soft tissue of the oral cavity and the jaw in HIVseropositive population. Although PBL presents generally in the oral cavity with local invasion and rapid dissemination to extraoral sites, it has been reported in other sites such as stomach, liver, cervical lymph nodes, lungs, orbit and paranasal sinuses [5][6][7][8][9]. More than 20% of extraoral PBL involve the lymph nodes, as we could see in our patients [10].…”

Heaviness in the chest and Hodgkin Lymphoma: An unusual presentation

“…Hodgkin's lymphoma occurs in the mediastinum presentation may be insidious. 4,5 Therefore the diagnostic approach should be in careful manner. Because it is a curable malignancy and failure to diagnose the disease may lead to many problems.…”

A rare presentation of plasmablastic lymphoma as cutaneous nodules in an immunocompromised patient

“…Oral cavity, lymph nodes and gastrointestinal tract are the common sites involved. 4,5 Rare sites of involvement reported were central nervous system, 6 mediastinum, lungs, 7 liver, skin, 8 subcutaneous tissue 9 and paranasal sinus. 10 It has a bimodal distribution with over 80% of patients presenting with stage 1 or 4.…”