Soft-Tissue Calcification in Uremia

Parfitt, A. M.

doi:10.1001/archinte.1969.00300210026004

Cited by 254 publications

(39 citation statements)

References 84 publications

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“…Interestingly, the increased prevalence of CAD in patients with moderate CKD was mainly contributed by the presence of non-obstructive CAD. The observation may partially be explained by the thickening and calcification in the media layer, instead of the intima layer, of the coronaries in patients with moderate CKD, a phenomenon that is classically described as Mönckeberg’s calcification or medial calcinosis [21, 22]. Therefore, in patients with moderate CKD, the elevated CCS located in the medial layer may be associated with non-obstructive coronary atherosclerosis, rather than significant luminal obstruction [23].…”

Section: Discussionmentioning

confidence: 99%

Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease

et al. 2013

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PurposeThe coronary calcium score (CCS) predicts significant coronary artery disease (CAD) in the general population. While moderate chronic kidney disease (CKD) is associated with high CCS, the use of CCS to predict significant CAD in these patients is unknown.MethodsA total of 704 patients underwent computed tomography coronary angiography for the assessment of CCS and CAD. Sixty-nine (10 %) patients had moderate CKD, defined by an estimated glomerular filtration rate (eGFR) between 30 and 59 mL/min/1.73m2, and the remaining patients were considered to be without significant CKD (eGFR ≥ 60 mL/min/1.73m2).ResultsPatients with moderate CKD were older, had a higher CCS, and a higher prevalence of obstructive CAD than patients without significant CKD. Receiver-operator curve analysis showed that CCS predicted the presence of obstructive CAD in both patients with moderate CKD and those without significant CKD. In patients with moderate CKD, the optimal cut-off value of CCS to diagnose obstructive CAD was 140 (sensitivity 73 % and specificity of 70 %), and is 2.8 fold higher than in patients without significant CKD (cut-off value = 50; sensitivity 75 % and specificity 75 %).ConclusionThe present results demonstrate that CCS can predict obstructive CAD in patients with moderate CKD, although the optimal cut-off value is higher than in patients without significant CKD.

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Section: Discussionmentioning

confidence: 99%

Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease

et al. 2013

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“…Calcium may also deposit in organs in which cells excrete acid and, therefore, have low carbon dioxide tension, due to which calcium becomes less soluble and precipitates. In one study, 8 it was stated that regression of soft-tissue calcifications can be dependent on the lowering of plasma phosphate level, which may be accomplished through dietary measures, phosphate binding medications, renal transplantation, and parathyroidectomy. In some cases a wide local excision may be necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Based on radiological observations, soft-tissue calcifications have been described in various sites such as skin, blood vessels, eye, periarticular areas, viscera, and the temporomandibular joint. 8,9 The presence of abundant calcium in a fine-needle aspiration cytology (FNAC) sample from a space-occupying lesion (mass) warrants consideration of certain conditions in the differential diagnosis. Examples include calcifying fibrous pseudotumor, sarcoid, lymphoepithelial lesion, osteitis fibrosa cystica, pilomatrixoma, and infection with Aspergillus.…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration cytology of the breast in a case with abundant acellular calcific material indicative of soft-tissue calcinosis

et al. 2000

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Since calcific deposits in soft tissue may clinically resemble a tumor, it is feasible to investigate them by fine‐needle aspiration (FNA) cytology. In this presentation we describe a case in the breast with extensive accumulation of acellular liquid calcific material which was sampled by the noninvasive technique of FNA, and which was indicative of nonfamilial soft‐tissue calcinosis. A 48‐yr‐old, perimenopausal woman on a routine mammogram showed a well‐defined, 1‐cm partially cystic opacity in the left upper quadrant of the breast. All other investigations were normal, and no significant family or medical history was present. Under ultrasound guidance FNA was done, and about 1 ml of thick whitish fluid was obtained. Cytopreparations only showed abundant acellular calcium. The patient refused any further treatment and elected to be under the care of her family physician, according to whom she was clinically well with no changes in mammograms for the last 2 yr. The case is interesting, since the cytohistologic findings in aspirate sample appeared to be strongly indicative of soft‐tissue calcinosis, which to our knowledge has not been previously reported. Diagn. Cytopathol. 2000;22:30–32. © 2000 Wiley‐Liss, Inc.

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“…However, improvements in management have resulted in a lower incidence of these calcific deposits. In one study 11 it was stated that regression of soft-tissue calcifications is dependent on lowering of plasma phosphate level, which may be accomplished through dietary measures, phosphate-binding medications, renal transplantation, and parathyroidectomy. In some cases, a wide local excision may be necessary.…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration cytology of soft-tissue calcinosis presenting as an enlarging mass in the chest wall

Gupta¹,

Naran²,

Cheung³

1998

Diagn. Cytopathol.

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Calcinosis cutis is an uncommon condition, and calcific deposits in patients with end‐stage renal disease are now somewhat rare, due to improvement in management. Since calcific deposits may clinically resemble a tumor, it is feasible to investigate them by fine‐needle aspiration cytology (FNAC). A 52‐yr‐old male with a history of end‐stage renal failure presented with a 2‐cm mass in the left chest wall. Within 6 mo the mass enlarged to nearly four times its original size. In view of clinical suspicion of malignancy, FNAC was performed. Cytopreparations showed abundant calcium, indicative of soft‐tissue calcinosis. The case is interesting, since the known history of end‐stage renal failure enabled the FNAC diagnosis of soft‐tissue calcinosis. Diagn. Cytopathol. 1998;19:465–467. © 1998 Wiley‐Liss, Inc.

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Soft-Tissue Calcification in Uremia

Cited by 254 publications

References 84 publications

Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease

Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease

Fine-needle aspiration cytology of the breast in a case with abundant acellular calcific material indicative of soft-tissue calcinosis

Fine-needle aspiration cytology of soft-tissue calcinosis presenting as an enlarging mass in the chest wall

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