Soft Tissue Attachment to Titanium Implants Coated with Growth Factors

Abstract

Background: Enhancing the connective tissue seal around dental implants may be an important factor in implant survival. Purpose: The objective of the study was to investigate the effect of implant surface modification with either platelet‐derived growth factor (PDGF) or enamel matrix derivative (EMD) on connective tissue attachment to titanium implants. Materials and Methods: Eighteen implants (Branemark® Mk III Groovy NP (3.3 mmØ × 10 mm, Nobel Biocare) were implanted subcutaneously into 12 rats. Six implants each were coated with either PDGF or EMD immediately prior to implantation and six implants were left uncoated. Implants were retrieved at 4 and 8 weeks and assessed histologically to compare the soft tissue adaptation to the implant surfaces. Results: Ingrowth by soft connective tissue into the threads of all implants was noted at 4 and 8 weeks. Coating with growth factors did not alter the orientation of fibroblasts and collagen fibers. The depth of connective tissue penetration into the implant grooves was significantly greater for the implants coated with PDGF at 4 weeks. The thickness of the connective tissue in growth was significantly less for the implants coated with PDGF at 8 weeks. Conclusion: Coating of the implant surface with rhPDGF‐BB or EMD can increase the speed and quantity of soft tissue healing around the implant surface.

Soft tissue conditions and marginal bone levels of implants with a laser‐microtextured collar: a 5‐year, retrospective, controlled study

“…; Bates et al. ). This different behavior may relate to the fact that laser microgrooves are an order of magnitude smaller in dimension than machine‐tooled microthreads.…”

Implantatoberflächen und ihr Einfluss auf das periimplantäre Hartgewebe

“…Im Gegensatz zu BMP zeigten PDGF und EMD in Kombination mit HA zwar keinen osteoinduktiven Effekt im Muskel [106], allerdings verbesserten sie die Weichgewebeheilung und somit den Gingivakontakt um das Implantat, wenn sie auf Titan immobilisiert wurden [107].…”

Viability of Titanium-Titanium Boride Composite as a Biomaterial

“…If determined to be biocompatible, then Ti-TiB w dual matrix composites have significant potential as a biomaterial. Previous studies have focused on surface features or coatings that influence soft tissue/ fibroblast attachment [10], including micromachined grooves [11], surface charge [12], growth factors [13], and TiN [14]. However, these coatings do not significantly enhance the bulk properties of the material and are not precluded by the development of new structural alloys for dental implants.…”