Soft Tissue Amyloidoma With Features of Plasmacytoma

Abstract

Soft tissue amyloidoma is rare, and soft tissue amyloidoma associated with plasmacytoma and without evidence of systemic amyloidosis is even more rare. We report a case of soft tissue amyloidoma associated with an apparently localized monoclonal proliferation of plasma cells (plasmacytoma).

Collapse in a 79-year-old: a rare case of amyloid tumour of the pelvis

“…Amyloidoma is a rare manifestation of amyloidosis where abnormal glycoprotein, usually light chain immunoglobulin (AL) or less commonly serum protein A (AA), is deposited locally, forming a solitary mass. Amyloidomas have been reported in a variety of anatomical sites including the gastrointestinal tract [1], central and peripheral nervous system [2], soft tissue [3] and bone. In a review of 34 cases of amyloidoma of the bone the mean age at diagnosis was 57 years (range 27-78), the duration of symptoms ranged from 1 month to 7 years, and the size of the tumour was, on average, 10 cm (range 4-15 cm) [4].…”

“…The pathophysiology of amyloidoma is unclear. Some reports suggest that the amyloid is produced within an immunocytic neoplasm such as a plasmacytoma [3,4]. This underlying malignancy may not be found at diagnosis due to 'burn out', where the neoplasm has been overwhelmed by amyloid deposits [9].…”

“…BBS is a serious complication of PEG tube insertion first described in 1988 [2,3] and reported to occur in 0.3-2.4% of patients [4]. It is a late complication occurring up to 3 years post PEG insertion [5], but has been described at 21…”