Soft Implantable Bioelectronics

Koo, Ja Hoon; Song, Jae Yoon; Kim, Dae‐Hyeong; Son, Donghee

doi:10.1021/acsmaterialslett.1c00438

Cited by 38 publications

(33 citation statements)

References 130 publications

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“…[15,16] However, the metal interfaces have disadvantages such as high stiffness, low electrochemical capacity, and poor tissue interaction. [17,18] To replace conventional metallic neural electrodes, novel materials and device structure must be developed.…”

Section: Introductionmentioning

confidence: 99%

Organic Neuroelectronics: From Neural Interfaces to Neuroprosthetics

Lee

Seo

et al. 2022

Advanced Materials

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signals transmit various information from internal and external environments of organisms to each organ. Neurological diseases can impede transmission of neural signals and can cause severe symptoms. These diseases significantly reduce the quality of life, and can also be life-threatening. Neurological disease is a leading cause of disability-adjusted lifeyears (DALYs) which affected more than 276 million people globally in 2016. [1] In 2010 in the US, DALYs of spinal cord injuries were 445 911, which was higher than those of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). [2] Drugs and neurosurgery are being developed to treat neurological diseases, but due to complex pathophysiology are not always effective. [3] Cell therapies repair the damaged tissues by introducing new cells, and gene therapies treat neurological disease by introducing genes into the body. These therapies enable fundamental treatment because they remove damaged cells and defective genes that are the causes of the diseases, but may cause severe or fatal side-effects such as immune responses. [4,5] Therefore, new methods for general treatment of neurological disease are being sought.Electric therapy is a promising method to diagnose disease by recording neural electronic signals and to treat disorders by using electrical signals to stimulate tissues. [6] The electrical stimulation has few side-effects, and is regarded as a possible and safe method to treat intractable neurological disorders. [7] For example, electrical stimulation has successfully recovered the lost functions from spinal cord injury. [8] However, despite these advantages, the development of neuroelectronics is still in its infancy; further research must be conducted to improve its efficacy and stability and to ensure that it does not limit daily life.Neuroelectronics can be divided into two main categories: neural interfaces that record or stimulate neural signals, and neuroprosthetics that replace damaged sensory and motor organs and neural signal pathway. Among the diverse forms of neuroprosthetics, this review focuses on bioelectronic devices that relay electrophysiological signals by bypassing damaged nerves. Conventionally, metal electrodes have been developed as a neural electrode for diagnosis and treatment due to their high electrical conductivity, and ease of processing in high density arrays. [9][10][11] For example, use of metal electrodes for electroencephalography (EEG) is a promising method to diagnose epilepsy. [12] Also, deep Requirements and recent advances in research on organic neuroelectronics are outlined herein. Neuroelectronics such as neural interfaces and neuroprosthetics provide a promising approach to diagnose and treat neurological diseases. However, the current neural interfaces are rigid and not biocompatible, so they induce an immune response and deterioration of neural signal transmission. Organic materials are promising candidates for neural interfaces, due to their mechanical softness, excellent electrochemical p...

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Section: Introductionmentioning

confidence: 99%

Organic Neuroelectronics: From Neural Interfaces to Neuroprosthetics

Lee

Seo

et al. 2022

Advanced Materials

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“…For this reason, there have been many difficulties in using biomedical devices in such areas. [ 292 ] To handle this problem, some devices integrated hooks to be fixed on organs like bladder or heart. However, this method induces piercing damage on the organs, which can cause severe irritation.…”

Section: Encapsulation For Implantable Bioelectronicsmentioning

confidence: 99%

Ultra‐Thin Flexible Encapsulating Materials for Soft Bio‐Integrated Electronics

2022

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Recently, bioelectronic devices extensively researched and developed through the convergence of flexible biocompatible materials and electronics design that enables more precise diagnostics and therapeutics in human health care and opens up the potential to expand into various fields, such as clinical medicine and biomedical research. To establish an accurate and stable bidirectional bio-interface, protection against the external environment and high mechanical deformation is essential for wearable bioelectronic devices. In the case of implantable bioelectronics, special encapsulation materials and optimized mechanical designs and configurations that provide electronic stability and functionality are required for accommodating various organ properties, lifespans, and functions in the biofluid environment. Here, this study introduces recent developments of ultra-thin encapsulations with novel materials that can preserve or even improve the electrical performance of wearable and implantable bio-integrated electronics by supporting safety and stability for protection from destruction and contamination as well as optimizing the use of bioelectronic systems in physiological environments. In addition, a summary of the materials, methods, and characteristics of the most widely used encapsulation technologies is introduced, thereby providing a strategic selection of appropriate choices of recently developed flexible bioelectronics.

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“…Thus, recent progress in the development of implantable sensing system with less tissue damage and chronical in vivo stability is highlighted, with a focus on the utilization of advanced materials and structural design concepts. [ 99 ] Furthermore, with the assistance of intelligent algorithm, complex data of BISS can be efficiently analyzed, leading to rapid sequences of highly dexterous behaviors and illness monitoring, which facilitate the study of biological activities and diseases treatment.…”

Section: Recent Progresses Of Bissmentioning

confidence: 99%

Recent Progress in Bio‐Integrated Intelligent Sensing System

Liu

Zhang

Tao

2022

Advanced Intelligent Systems

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It is incontrovertible that the bioelectronic enabled bio‐integrated system is one of the most promising technologies in the upcoming decades. Driven by the great versatility of the emerging artificial intelligence, machine‐learning‐supported bio‐integrated intelligent sensing system (BISS) is capable of achieving data processing and intelligent recognition while conducting multimodal human‐centered sensing; such facilitated systems capitalize the benefits of both bioelectronics and supporting algorithm, enabling accurate physiological/somatosensory recognition at the cost of certain computing resources. Herein, an overview of recent progress in BISS is presented, with an emphasis on high‐tech applications enabled by innovations in combining flexible bioelectronic sensors with supporting algorithmic systems. The main applications can be divided into three categories, including implantable, skin‐mounted, and wearable BISS, which have different requirements for materials, fabrication methods, and algorithms, respectively. Advances in these areas open new avenues for employing BISS as future human–machine interfaces for personalized healthcare, human enhancement, as well as other broad applications.

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Soft Implantable Bioelectronics

Cited by 38 publications

References 130 publications

Organic Neuroelectronics: From Neural Interfaces to Neuroprosthetics

Organic Neuroelectronics: From Neural Interfaces to Neuroprosthetics

Ultra‐Thin Flexible Encapsulating Materials for Soft Bio‐Integrated Electronics

Recent Progress in Bio‐Integrated Intelligent Sensing System

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