The aim of this research was to develop a coherent theoretical proposal for counteracting drug trafficking in Russia and Germany. The methodological basis of the research is the dialectical and worldview approach. The latter determined the application of the general principles of cognition to study the current situation of drug abuse in Russia and Germany. Among the results stands out the fact that, previously tested forms of preventive work require careful restructuring and adjustment on the example of the implementation of the Strategy of the State Anti-Drug Policy of the Russian Federation until 2030, which implies the involvement of various actors in the organization of preventive work. In addition, the scientific results of the research include a critical analysis of the legislation on drug trafficking, trends in the drug situation and criminological study of persons involved in drug trafficking. In conclusion, the authors provided a legal formulation of certain areas of the fight against drug trafficking in the Russian Federation and Germany.