2017
DOI: 10.1016/j.jceh.2017.05.054
|View full text |Cite
|
Sign up to set email alerts
|

Sofosbuvir Based Regimen in Management of Hepatitis C for Patients With End Stage Renal Disease on Hemodialysis: A Single Center Experience From India

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
3
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(5 citation statements)
references
References 20 publications
0
3
0
Order By: Relevance
“…In the former study 66% of patients received daily RBV and 27% received daily SOF dose, whereas our haemodialysis patients received their treatment every other day prior to haemodialysis sessions. As mentioned before many recent studies showed that lower dose of SOF is associated with lower efficacy [15][16][17][18][19][20][21] Our study has unique strengths compared to previous studies.…”
Section: Discussionmentioning
confidence: 83%
See 1 more Smart Citation
“…In the former study 66% of patients received daily RBV and 27% received daily SOF dose, whereas our haemodialysis patients received their treatment every other day prior to haemodialysis sessions. As mentioned before many recent studies showed that lower dose of SOF is associated with lower efficacy [15][16][17][18][19][20][21] Our study has unique strengths compared to previous studies.…”
Section: Discussionmentioning
confidence: 83%
“…[13][14][15][16] Though smaller doses of the drug (200 mg/d or 400 mg on alternate day) were used by some investigators, several authors showed lower SVR rates with such doses. [15][16][17][18][19][20][21] On the other hand, high efficacy and safety of full dose SOF-containing regimens in patients with severe renal impairment were also demonstrated by many investigators. 13,17,18,[22][23][24][25][26] The purpose of this study was to report the experience of using SOF-based therapy to treat a large number of HCV patients by the health authorities in Egypt, with a significant number of them having CKD.…”
Section: Introductionmentioning
confidence: 98%
“…As a result, several studies have been conducted with reduced doses of sofosbuvir using either half daily doses or an alternating full dose. The combination of sofosbuvir 200 mg daily with daclatasvir 60 mg daily has been shown to be effective with cure rates of 90-100% [25,29,40,41]. Similarly, combinations with an alternating full dose of sofosbuvir were effective with cure rates of 82.3 to 100% [27,28,42].…”
Section: Discussionmentioning
confidence: 99%
“…We achieved a RVR in 83.3%. Rates ranging from 88.3 to 100% have been reported in literature [25][26][27][28][29]. Historically, RVR has been a predictor of healing [30,31].…”
Section: Discussionmentioning
confidence: 99%
“…Despite our results were not corroborated in patients with decompensated disease, they are strikingly in keeping with those obtained by Garg et al in a population with different ethnic and demographic background, and therefore, we feel that what has been observed in the study carried out in northern India can also easily be transferred to other settings. 3 Finally, we feel that, taking into account durability of response to antiviral treatment, even longer periods of time will be required so as to assess the fate of those cirrhotic patients-who represent approximately 50% of the treated population-where there is no apparent improvement in a relatively shorter follow-up and to identify outcome predictors. 4…”
mentioning
confidence: 99%