Sofa dermatitis: Value of patch test with 2‐(thiocyanomethylthio)benzothiazole

Abstract

Background: In 2008, numerous cases of allergic contact dermatitis caused by leather chairs (sofa dermatitis) were reported, with dimethylfumarate being the culprit allergen.However, octylisothiazolinone, methylisothiazolinone and cobalt have also been associated with cases of sofa dermatitis. An antifungal agent, 2-(thiocyanomethylthio)benzothiazole (TCMTB), has also previously been described as a contact allergen in leather.Materials and Methods: Seven patients were referred to the Department of Dermatology of the Cliniques universitaires Saint-Luc, Brussels, Belgium with suspicion of allergic contact dermatitis caused by leather sofas. They were patch tested with the European Baseline Series, additional series (according to the patients' history and clinical aspect of the eruption), dimethylfumarate (4/7 patients) and with TCMTB.Results: All seven patients presented a positive reaction to TCMTB and only one presented a concomitant positive reaction to dimethylfumarate. All patients showed clinical improvement after avoiding contact with their leather sofa. Conclusion:2-(Thiocyanomethylthio)benzothiazole (TCMTB) is probably an underestimated allergen present in leather chairs (responsible for the so-called 'sofa dermatitis'), and more generally in leather objects. It is, therefore, important to test with TCMTB 0.1% petrolatum in case of contact dermatitis related with leather products.

Increasing non‐cosmetic exposure and sensitization to isothiazolinones require action for prevention: Review

“…The description ‘sofa dermatitis’ was widely discussed when the antifungal dimethyl fumarate (DMF) had been identified as the cause of acute dermatitis from some furniture and leather articles 55 . OIT and MI, and recently 2‐(thiocyanomethylthio)benzothiazole (TCMTB), have likewise been identified as responsible for a similar clinical picture 56 …”