SOFA coagulation score and changes in platelet counts in severe acute kidney injury: Analysis from the randomized evaluation of normal versus augmented level (RENAL) study

Abstract

In the RENAL study, thrombocytopenia is a common phenomenon in patients with severe AKI receiving CRRT. An abnormal baseline SOFA-CS and reductions in platelet counts were associated with increased mortality at 90 days.

Analysis of risk factors of acute kidney injury in organ donors

“…The higher the score is, the more serious the illness is, which can better reflect the severity of the patient's situation. The more severe the disease, the higher the incidence of AKI [13]. Therefore, in this study, SOFA score is correlated with the incidence of AKI in the donor, which is clinically consistent.…”

Thrombocytopenia in intensive care unit patients: A scoping review

“…Overall, thrombocytopenia was associated with increased mortality in most studies, both in the shorter term (ICU through day 90 or end hospital stay whichever came first) 3,6,7,9,10,12,13,19,22,28,30,31,33,34,38,39,41,43,44,46,47,51,52,59,61,64,67,69,71,75 and the longer term (one report at 6 months and two reports at one year) 27,34,42 . The severity of thrombocytopenia was associated with increased mortality in most studies 6,7,12,14,34,44,46,47,51,55,72 …”

“…Identified studies eligible for inclusion were published in the period from 1983 to 2019. Six of the included studies were case‐control studies, 5,19‐23 one was an RCT, 24 five were post hoc analyses of RCTs, 7,25‐28 one study was a protocol for an RCT, 29 and 57 studies were cohort studies 3,6,8‐14,30‐77 …”

“…The definitions and categories of thrombocytopenia used in the included studies are presented in Table 1. In 50 (71%) of the included studies, thrombocytopenia was defined according to an absolute platelet count, 3,5‐14,19,21,23,27,28,30‐34,36‐44,46,47,49,51,52,55‐57,59‐62,64,65,68,69,71‐75 and in 7 (10%) studies thrombocytopenia was further or exclusively (one study) defined by a relative decrease in platelet count (range > 30% to > 50% decrease) 21,23,38,53,57,59,65 . Most studies graded thrombocytopenia as mild when the platelet count was <150 × 10 9 /L, moderate; <100 × 10 9 /L, severe; <50 × 10 9 /L and very severe; <20 × 10 9 /L (or <30 × 10 9 /L) 3,6,7,9‐14,19,22,28,30,34,37,42,46,47,49,51,54,55,60‐62,69,71,73,74 ; some studies used other grades of severity 8,23,36,40,75 …”

“…Patient with thrombocytopenia more frequently used inotropic or vasopressor therapy 7,12,30,39,62,72 or renal replacement therapy 7,10,12,28,38,61,72 even though this was not fully consistent 39,61,77 . In most studies, the use of mechanical ventilation was not associated with thrombocytopenia 13,30,34,38,55,61,62,71,72,77 …”