Sodium valproate induced gingival enlargement in 22 months old child

Chandulal, Dhalkari; Ganatra, Pallav

doi:10.4103/0972-124x.142465

J Indian Soc Periodontol

2014

DOI: 10.4103/0972-124x.142465

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Sodium valproate induced gingival enlargement in 22 months old child

Dhalkari Chandulal

Pallav Ganatra

Abstract: Gingival enlargement is a common clinical feature seen in patients suffering from gingival and periodontal diseases and is a common side-effect of drugs such as anti-convulsants, calcium channel blockers and immunosuppresants. This is a case report of 22 months old child suffering from gingival enlargement following intake of sodium valproate. Among the anti-convulsants phenytoin is commonly associated with gingival enlargement; however, there are not many cases reported on sodium valproate induced gingival en… Show more

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Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

Oktay¹,

Alev²,

Öztürk³

et al. 2016

Marmara Pharm J

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ABSTRACTvalproic acid (2-n-propylpentanoic acid, vPA), the most widely used antiepileptic drug, has potential adverse effects and it can disrupt the oxidant and antioxidant balance. Edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one, EDA) is a potent free radical scavenger. In this study, the effect of EDA on gingiva in vPA induced toxicity was investigated. female Sprague Dawley rats were randomly divided into four groups: control group, EDA (30 mg/kg/day) given group, vPA (0.5 g/kg/day) given group, and vPA+EDA (in same dose and time) given group. EDA and vPA were given intraperitoneally for seven days. Total protein, lipid peroxidation (LPO), sialic acid (SA) and reduced glutathione (GSH) levels and catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), myeloperoxidase (mPO), alkaline phosphatase (ALP), acid phosphatase (ACP), sodium potassium ATPase (na + /K + -ATPase) and tissue factor (Tf) activities were determined in gingiva homogenates. The vPA-induced increases were statistically significant for mPO (p<0.01), ACP (p<0.01), na + /K + -ATPase (p<0.05) and Tf (p<0.01) activities, but not for LPO level and ALP activities. EDA treatment markedly blunted all such elevated anomalies. Conclusively, vPA induced oxidative and inflammatory gingival tissue damage, reactions that were appreciably reversed by concurrent administration of EDA.

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Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

Oktay¹,

Alev²,

Öztürk³

et al. 2016

Marmara Pharm J

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Sodium valproate induced gingival enlargement in 22 months old child

Cited by 1 publication

References 10 publications

Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

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