Sodium valproate and cognitive functioning in normal volunteers.

Thompson, Pam; Trimble, Michael

doi:10.1111/j.1365-2125.1981.tb01313.x

Cited by 98 publications

(35 citation statements)

References 12 publications

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“…The day 3 comparison with placebo suggests that VPA alone has no important acute effect on psychomotor function. This is in general agreement with previous studies which have reported, at worst, only isolated decrements in cognitive function with the drug (Harding & Pullan, 1977;Sommerbeck etal., 1977;Thompson & Trimble, 1981). VPA treatment had a minor effect on the objective psychomotor test profile of CBZ.…”

Section: Analysesmentioning

confidence: 95%

Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

Macphee

Mitchell

Wiseman

et al. 1988

Brit J Clinical Pharma

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1 The effect of sodium valproate (VPA; 500 mg thrice daily for 7 days) and matched placebo on the disposition and psychomotor profile of a single dose of carbamazepine (CBZ; 10 mg kg-1) was studied in eight healthy male subjects using a randomised balanced crossover design.2 VPA alone had no effect on antipyrine clearance, urinary 6p-hydroxycortisol excretion and a battery of psychomotor function tests after 3 days' treatment despite achieving a mean steady-state concentration (90 ± 6 mg 1-1) well within the target range (50-100 mg I-1) for the drug.3 VPA pre-treatment did not alter total CBZ area under the concentration-time curve (AUC 0-59 h) but did prolong CBZ elimination half life by 12% (P < 0.01). AUC 0-59 h for free plasma CBZ was 13% higher (P < 0.02) and half-life of unbound CBZ 16% longer (P < 0.02) during VPA treatment. CBZ-10, 11 epoxide (CBZ-E) levels (52%) and CBZ-E/ CBZ ratios (45%) were both elevated by concurrent VPA (P < 0.05) and free CBZ fraction was increased by 7% (P < 0.02). 4 The sole effect of VPA on the psychomotor profile of CBZ was prolongation of card sorting time (P < 0.05), although CBZ-related side effects were reported as more severe when VPA was also taken (P < 0.01). 5 These data suggest that VPA displaces CBZ from plasma protein binding sites and inhibits the metabolism of both the parent drug and its epoxide. The effect of VPA on the psychomotor profile of a large single dose of CBZ was minimal. 6 Further studies in epileptic patients receiving both these anticonvulsant drugs are warranted to appraise the extent and clinical relevance of their interaction.

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Section: Analysesmentioning

confidence: 95%

Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

Macphee

Mitchell

Wiseman

et al. 1988

Brit J Clinical Pharma

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“…37 The card was removed and the athlete asked to recall the words. The score was the number correctly recalled.…”

Section: Immediate Word Recall (Iwr)mentioning

confidence: 99%

A prospective controlled investigation of the cognitive effects of amateur boxing.

Butler¹,

Forsythe²,

Beverly³

et al. 1993

Journal of Neurology, Neurosurgery & Psychiatry

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Eighty six amateur boxers underwent a series of neuropsychological assessments on three occasions-pre bout, immediate post bout and follow up within two years; 31 water polo players and 47 rugby union players acted as controls. The neuropsychological tests were selected as being sensitive to subtle cognitive dysfunction and formed part of a battery of other neurological and ophthalmic assessments. No evidence of neuropsychological dysfunction due to boxing was found, either following a bout or a series of bouts at follow up. None of a range of parameters including number of previous contests, recovery from an earlier bout, number of head blows received during a bout and number of bouts between initial assessment and follow up, were found to be related to changes in cognitive functioning.

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“…Тем не менее, в отдельных исследованиях было показано отрица-тельное влияние вальпроата (по выраженности -от легкого до умеренного) на скорость психомоторных реакций и скорость мыслительных процессов [28,29,38,66,81].…”

Section: старые антиэпилептические препаратыunclassified

The Formation of Cognitive and Mental Disorders in Epilepsy: The Role of Various Factors Associated With Disease and Treatment (A Review of Literature and Case Reports)

Мухин¹,

Пылаева²

2017

Rus. ž. det. nevrol.

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Sodium valproate and cognitive functioning in normal volunteers.

Cited by 98 publications

References 12 publications

Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

A prospective controlled investigation of the cognitive effects of amateur boxing.

The Formation of Cognitive and Mental Disorders in Epilepsy: The Role of Various Factors Associated With Disease and Treatment (A Review of Literature and Case Reports)

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