2021
DOI: 10.3389/fimmu.2021.671935
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Sodium Thiosulfate Improves Intestinal and Hepatic Microcirculation Without Affecting Mitochondrial Function in Experimental Sepsis

Abstract: IntroductionIn the immunology of sepsis microcirculatory and mitochondrial dysfunction in the gastrointestinal system are important contributors to mortality. Hydrogen sulfide (H2S) optimizes gastrointestinal oxygen supply and mitochondrial respiration predominantly via K(ATP)-channels. Therefore, we tested the hypothesis that sodium thiosulfate (STS), an inducer of endogenous H2S, improves intestinal and hepatic microcirculation and mitochondrial function via K(ATP)-channels in sepsis.MethodsIn 40 male Wistar… Show more

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Cited by 5 publications
(4 citation statements)
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“…However, i.p. administration of 1 g/kg of sodium thiosulfate did not impact intestinal and hepatic mitochondrial functions in septic rats [ 66 ]. STS was shown to exert cardioprotective effects in mice but when applied orally in drinking water, in a dose of 3 mg/mL per day (that equals approx.…”
Section: Discussionmentioning
confidence: 99%
“…However, i.p. administration of 1 g/kg of sodium thiosulfate did not impact intestinal and hepatic mitochondrial functions in septic rats [ 66 ]. STS was shown to exert cardioprotective effects in mice but when applied orally in drinking water, in a dose of 3 mg/mL per day (that equals approx.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, STS was used, an H 2 S donor devoid of major undesired side effects and recognized for cyanide intoxication, cis-Pt-overdosing in oncology, as well as calciphylaxis in end stage kidney disease (1). STS has been shown to be beneficial in LPS-and polymicrobial sepsis-induced ALI (5), acute liver failure (4) and I/R injury (3), Pseudomonas aeruginosa-bacteremia (7) and colon ascendens stent peritonitis-induced sepsis (38) as well as both LPS-( 6) and I/R-induced (2) brain injury. Moreover, STS also protected against arterial hypertension-induced congestive heart failure (39,40) and kidney disease (41,42).…”
Section: Discussionmentioning
confidence: 99%
“…and volume administration s.c. and were scored using the predefined Septic Rat Severity Score (SRSS). The SRSS is based on the Murine Sepsis Score [ 51 ] and was adjusted for rats in several previous studies by our working group [ 40 , 52 , 53 ]. Animals reaching the maximal allowed score of 10 points were euthanized by administering sodium pentobarbital (120 mg/kg b.w., i.p).…”
Section: Methodsmentioning
confidence: 99%