Sodium tanshinone IIA sulfonate inhibits tumor growth via miR-138 upregulation in intermittent hypoxia-induced xenograft mice
Xiao-Bin Zhang,
Qi-Feng Gan,
Xiu-Zhen He
et al.
Abstract:Purpose: We studied the functions of sodium tanshinone IIA sulfonate (TSA) in inducing tumor growth in obstructive sleep apnea (OSA)-mimicking intermittent hypoxia (IH) xenograft mice and the underlying potential molecular mechanism.
Methods: RNA sequencing was conducted to screen the differentially expressed microRNAs in cell lines exposed to IH with or without TSA treatment. As part of the 5-week
in vivo
study, we treated xenograft mice with 8-h IH once daily. TSA and miR-13… Show more
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