Sodium selenite/selenium nanoparticles (SeNPs) protect cardiomyoblasts and zebrafish embryos against ethanol induced oxidative stress

Kalishwaralal, Kalimuthu; Jeyabharathi, Subhaschandrabose; Sundar, Krishnan; Muthukumaran, Azhaguchamy

doi:10.1016/j.jtemb.2015.06.010

Cited by 30 publications

(16 citation statements)

References 36 publications

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“…Recently, it has been shown that AgNP induces mitochondrial stress and treatment with selenite is capable of preventing the adverse effects of AgNP on the mitochondria [46]. Also possible application of Se on oxidative processes is known [47,48].…”

Section: Discussionmentioning

confidence: 99%

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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Metal nanomaterials hold great potential and play an important role in consumer products. However, the increasing use of nanomaterials has raised concern over inadvertent exposure and potential risks for human health and the environment. Henceforth, in vivo testing of nanoparticles and protection against its toxicity is required. Using rat as an animal model, effect of sodium selenite (Se), an essential trace element, on rat testes exposed to silver nanoparticles (AgNPs) was evaluated. Male rats were treated with AgNPs (5 mg/kg/b.w) i/p or Se (0.2 mg/kg/b.w) by gavage. AgNP administration decreased Glutathione (GSH) levels and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and increased levels of malondialdehyde (MDA) and expression of interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor alpha (TNF-α). However, treatment with Se increased GSH levels and activities of SOD, CAT, and GPx compared with AgNP-treated group and decreased the level of MDA and inflammatory biomarkers significantly (p < 0.05) as compared with AgNP-treated group. Light microscopic analyses also revealed that AgNP induced histopathological changes in testes tissue. Further, protection by Se on biochemical results was confirmed by alleviation of the histopathological changes in the tissue. Results show the adverse effects of AgNPs on the male reproductive tract, particularly spermatogenesis, and suggest that Se possesses significant potential in reducing AgNP-induced testicular toxicity.

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Section: Discussionmentioning

confidence: 99%

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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“…3 One promising area of research is the application of nanotechnology towards selenium fabrication and use. [6][7][8][9][10] Nanoparticles (NPs) are particularly suitable as they possess high surface area to volume ratios, increased surface area, and increased interactions with biological targets, leading to higher availability and absorption by the host. [11][12][13] In addition, selenium NPs (SeNPs) possess lower toxicity than their elemental form; in mice, the LD 50 of selenomethionine was 25.6 mg Se/kg compared with 92.1 mg Se/kg for SeNPs.…”

Section: Introductionmentioning

confidence: 99%

<p>Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth</p>

Chung¹,

Zhou²,

Webster³

2020

IJN

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Background: Selenium is an essential trace element that is critical for many biological processes. Selenium nanoparticles (SeNPs) have shown more promise than other forms of selenium due to their low cytotoxicity and high bioavailability. Methods: In this work, a one-step method was demonstrated for fabricating bovine serum albumin (BSA) stabilized SeNPs using ascorbic acid as the reductant. Human dermal fibroblasts were used to assess mammalian cytotoxicity, and Staphylococcus aureus and Escherichia coli were used to assess antibacterial performance. Results: These SeNPs demonstrated increased fibroblast growth and reduced Staphylococcus aureus growth with a fibroblast IC 50 value (>681 μg/mL) 1 order of magnitude higher than that for bacteria at day 1. Conclusion: This study demonstrated the promise of this synthesis process in achieving controllable selenium nanoparticle sizes without the use of strong basic solvents for improved antibacterial properties.

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“…According to Kalishwaralal et al, selenium compounds (sodium selenite/selenium nanoparticles) showed cardioprotective effects in Danio rerio embryos exposed to ethanol. Selenium and SeNPs were found to reduce the 1% ethanol-induced oxidative damage through scavenging intracellular reactive oxygen species [21].…”

Section: Discussionmentioning

confidence: 99%

Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis

Prystupa¹,

Kiciński²,

Luchowska-Kocot³

et al. 2017

Ann Agric Environ Med.

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Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines in patients with alcoholic liver cirrhosis. Ann Agric Env Med. 2017; 24(3): 544-548. doi: 10.26444/aaem/76937 Abstract Introduction and objective. Liver cirrhosis is a disease involving the liver parenchyma, which is characterised by fibrosis. and impaired architectonics of the parenchyma with regenerative nodules. The aim of the study was to determine the relationship between stage of alcoholic liver cirrhosis, concentrations of selenium, zinc and profibrotic and proangiogenic cytokines ENG). Materials and method. The study included 99 patients with alcoholic cirrhosis and 20 healthy subjects. Ion chromatography with UV/VIS detection was used for determination of zinc ions in the previously mineralized serum samples. The measurements of selenium were performed with the ContrAA700 high-resolution continuum source graphite tube atomic absorption spectrometer. ELISA was used to determine concentration of FGF-19 and ENG in serum samples. Results. Concentrations of zinc and selenium were significantly decreased in cirrhotic patients (p<0.001 for both). The highest concentration of FGF-19 was found in Child-Pugh stage C liver cirrhosis patients (806.9±650.3 pg/ml), and was significantly higher than observed in controls (p=0.005) and stage A patients (compensated cirrhosis) (p=0.02). The highest concentration of ENG was demonstrated in the control group (3.24±148 ng/ml) while the lowest in patients with decompensated cirrhosis (7.32±5.39 ng/ml and 7.92±4.18 ng/ml for stage B and C; p=0.03 and p=0.02, respectively). The use of the multiple-variable model demonstrated that the independent factors affecting the concentration of ENG were the concentration of bilirubin (p=0.02), INR (p=0.01) and duration of alcohol abuse (p=0.02). The independent determinants of FGF-19 concentrations were found to be the stage (severity) of liver cirrhosis (p=0.04) and INR (p=0.03). Conclusions. Concentrations of zinc and selenium in serum of patients with alcoholic liver cirrhosis are not independently related to concentrations of FGF-19 and ENG.

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Sodium selenite/selenium nanoparticles (SeNPs) protect cardiomyoblasts and zebrafish embryos against ethanol induced oxidative stress

Cited by 30 publications

References 36 publications

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

<p>Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth</p>

Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis

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