Sodium-potassium ATpase, calcium, and immunological histamine release

Sodium‐potassium ATPase inhibition potentiates compound 48/80‐induced histamine secretion from mast cells

“…This study clearly shows that sodium-potassium ATPase is involved in the regulation of histamine release, from rat mast cells, induced by compound 48/80, confirming our recent observation with antigen triggered mast cells (Frossard et al, 1983). We show in the present paper that a long preincubation time with ouabain or in the absence of potassium was required to observe their potent effects.…”

“…These results suggest a critical role for sodium-potassium ATPase in the control of secretion phenomena, the inhibition of the enzyme leading to the increase of secretion. We recently proposed such a role for sodium-potassium ATPase in the antigen-induced histamine release from rat peritoneal mast cells (Frossard et al, 1983).…”

Mechanism of histamine secretion from rat mast cell by calcium reintroduction.

“…On the other hand, it has to be kept in mind that the same treatment inhibiting Na pumping activity potentiates the response to antigen, compound 48/80 or A 23187 (FROSSARD et al, 1983;AMELLAL et al, 1984AMELLAL et al, , 1985. We also confirmed that the same treatment potentiated the response to 48/80 in the presence of EGTA (1 mM), which utilized membrane Ca stores (DOUGLAS and UYEDA, 1973;GARLAND and PAYNE, 1979;PEARCE, 1982).…”

Inhibition of Na+ ‐K+ pump activity by divalent cations in intact peritoneal mast cells of the rat

“…The secretory responses of mast cells and other tissues are enhanced by digitalis glycosides (Vizi, 1978;Frossard et al, 1983;Powis, 1983;Amellal et al, 1984;1985 and references therein;Binck et al, 1985). Recently, we characterized the Na+-K+ pump mechanism in intact peritoneal mast cells of the rat and provided evidence for modulation of the pump activity by changes in the sodium permeability of the plasma membrane by extracellular calcium (Knudsen & Johansen, 1989a,b).…”