Sodium-Potassium-ATPase Activity Is Influenced by Ethnic Origin and Not by Obesity

Beutler, Ernest; Kühl, W; Sacks, Peter V.

doi:10.1056/nejm198309293091303

Cited by 97 publications

(24 citation statements)

References 9 publications

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“…Na-K ATPase activity in red cells is thought to be influenced by several factors, such as body weight, meals (Mir et al, 1982) and genetic disposition (Beutler et al, 1982), but the results of the present study revealed a close correlation with the thyroid status. Lin and Akera (1978) reported that the administration of T3 to rats resulted in an increased tissue concentration of Na-K ATPase in liver, kidney and skeletal muscle, but not in brain despite its highest affinity for ouabain-binding sites.…”

Section: Discussioncontrasting

confidence: 39%

Na-K-dependent ATPase in red cells and thyroid status.

et al. 1982

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The Relationship between ouabain-sensitive ATPase (Na-K ATPase) activity in erythrocytes and the thyroid status was studied in 36 patients with Graves' disease ren served as control. Clinically euthyroid children treated with L-T4 were divided into 2 groups with regard to Na-K ATPase activity, normal and low. Analysis of the possible factors peared to be the endogenous T4 level, while in patients with dwarfism, the secretory capacity of TSH or TSH-releasing hormone (TRH) was contributory. Thus Na-K ATPase activity in red cells remains within the normal range after L-T4 replacement in the presence of a severe degree of primary hypothyroidism or in association with secondary or tertiary hypothyroidism.Other factors such as the L-T4 dose, duration of the therapy, serum T4 and T3 concentrations, were not significantly different in the two groups. These results indicate that (1) Na-K ATPase in red cells is decreased in hyper-or hypothyroid state, (2) restoration of normal activity requires 1-3 months of euthyroid period, and (3) it is a sensitive index of peripheral thyroid status over the preceding few months.

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Section: Discussioncontrasting

confidence: 39%

Na-K-dependent ATPase in red cells and thyroid status.

et al. 1982

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“…Constitutional variations in erythrocyte Na/K ATPase activity have been associated with sex and ethnic origin, with lower activity having been reported in men than women, in blacks than whites, in Asians than Scandinavians [18,19], and in people of Semitic origin than Caucasians [14,15,20]. Semitic peoples are predisposed to severe and early diabetic neuropathy [9].…”

Section: Discussionmentioning

confidence: 99%

“…Na/K ATPase activity in erythrocytes varies according to ethnic origin. It is lower in blacks and North Africans, who are predisposed to neuropathy in the case of diabetes [9], than in Caucasians and Scandinavians [18,19].…”

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confidence: 99%

Association of diabetic neuropathy with Na/K ATPase gene polymorphism

Vague¹,

Dufayet²,

Coste³

et al. 1997

Diabetologia

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Neuropathy is a leading cause of disability in diabetes mellitus. Unlike diabetic retinopathy which is an almost constant long-term complication, diabetic neuropathy occurs in only 50 % of cases [1]. This phenomenon is comparable to that observed with diabetic nephropathy [2] which has been associated with genetic susceptibility [3,4]. A number of facts suggest Diabetologia (1997) 40: 506-511 Association of diabetic neuropathy with Na/K ATPase gene polymorphism Summary Diabetes mellitus induces a decrease in Na/K ATpase activity in man and animals, and this decrease plays a role in the development of diabetic neuropathy. Na/K ATPase is encoded by various genes, of which the ATP1 A1 gene is expressed predominantly in peripheral nerves and in erythrocytes. To investigate whether a polymorphism in the Na/K ATPase genes could explain the predisposition of some patients with insulin-dependent diabetes mellitus (IDDM) to develop polyneuropathy, a restriction fragment length polymorphism (RFLP) of the ATP1 A1 gene was studied together with erythrocyte Na/K ATPase activity in 81 Caucasian patients with more than 10 years' duration of IDDM. Associations with diabetic neuropathy, retinopathy and nephropathy were sought. Digestion of the first intron of the ATP1 A1 gene by the Bgl II restriction enzyme revealed a dimorphic allelism. Frequency of the restricted allele was 0.18 in this selected series (however, it was 0.10 in representative samples of IDDM patients and of normal subjects in our area). Mean erythrocyte Na/K ATPase activity was lower in diabetic patients than in 42 control subjects (292 ± 10, vs 402 ± 13 nmol Pi ⋅ mg protein − 1 ⋅ h − 1 , p < 0.0001) and was not related to HbA 1c value or to diabetes duration. It was lower in the group of the 28 patients bearing the restricted allele (241 ± 10 vs 319 ± 11 nmol Pi ⋅ mg protein − 1 ⋅ h − 1 , p < 0.0001).Neuropathy was absent in 50 patients, mild in 15 and severe in 16. When classified accordingly the three groups of patients did not differ with respect to sex, age and duration of diabetes. The respective frequency of the restricted allele among the groups was 10, 73 and 81 %, (p < 0.0001) and mean erythrocyte Na/K ATPase activity was respectively: 322 ± 10.7 nmol Pi ⋅ mg protein − 1 ⋅ h − 1 , 268 ± 15 and 229 ± 17, (p < 0.001). A borderline association between renal status or retinal status and repartition of polymorphism and a borderline correlation between renal status and Na/K ATPase activity were found, but significance disappeared after checking for the presence or absence of neuropathy. IDDM patients bearing the ATP1 A1 variant detected by Bgl II RFLP are much more frequently affected by neuropathy (relative risk 6.5, with 95 % CI 3.3-13). Identification of this risk factor may help to prevent this complication. It is suggested that the restricted allele is in linkage disequilibrium with a genomic mutation allowing diabetes to induce a greater impairment of Na/K ATPase activity which could in turn favour the development of neuropathy. [Diabetologia (199...

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“…Moreover, other factors than gene variability may be responsible for the (31)(32)(33). However, other investigators have found no differences (24,25,(34)(35)(36)(37). Interestingly, the Na,K-ATPase activity of obese human subjects has been found to be elevated in tissues or organs that consume much energy such as liver (38) and skeletal muscle (39).…”

Section: Discussionmentioning

confidence: 96%

“…First, the Na,K-ATPase activity seems to be partly heritable. Differences in erythrocyte Na,K-ATPase activities have been found between ethnic groups (24,25) but family members have generally similar erythrocytes enzyme activities (24). Second, the activity of this enzyme seems to be related to metabolic rate.…”

Section: Discussionmentioning

confidence: 99%

DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat.

Dériaz¹,

Dionne²,

Pérusse³

et al. 1994

J. Clin. Invest.

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The aim of this study was to investigate in 261 subjects from 58 families the association between DNA variation at the genes coding for the NaK-ATPase peptides and resting metabolic rate (RMR), respiratory quotient (RQ), and percent body fat (%FAT). Five restriction fragment length polymorphisms (RFLP) at three NaK-ATPase genes were determined: one at the al locus (BglII), two at the a2 locus (a2 exon 1 and a2 exon 21-22 with Bgl II), and two at the (3 locus (ft MspI and ft PvuII). Haplotypes were determined from the two variable sites of the a2 gene (a2 haplotypes) and the ft gene ((3 haplotypes). There was a strong trend for %FAT to be related to the RFLP generated by BglII at the a2 exons 21-22 in males (P = 0.06) and females (P = 0.05). RQ was (a) associated with the BglII RFLP at the a2 exon 1 (P = 0.02) and with the a2 8.0 kb/4.3 kb haplotype (P = 0.04) and (b) linked with the ft gene MspI marker (P = 0.04) and with the (35.3 kb/5.1 kb haplotype (P = 0.008) based on sib-pair analysis. The present study suggests that the genes encoding Na,K-ATPase may be associated or linked with RQ and perhaps with %FAT but not with RMR. (J. Clin. Invest. 1994. 93:838-843.)

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Sodium-Potassium-ATPase Activity Is Influenced by Ethnic Origin and Not by Obesity

Cited by 97 publications

References 9 publications

Na-K-dependent ATPase in red cells and thyroid status.

Na-K-dependent ATPase in red cells and thyroid status.

Association of diabetic neuropathy with Na/K ATPase gene polymorphism

DNA variation in the genes of the Na,K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat.

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