Sodium ozagrel and atorvastatin for type 2 diabetes patients with lacunar cerebral infarction

Yu, You; Wang, Lin; Zhu, Xu; Liu, Yafei; Ma, Heng

doi:10.4239/wjd.v12.i12.2096

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…Subsequently, the investigation results of clinical efficacy showed a higher response rate in AP + ATO group compared with ATO group, suggesting that AP + ATO has a more significant therapeutic effect on CA. Yu Y, et al also pointed out that AP has a certain improvement effect on cerebral thrombosis [ 15 ], which can also corroborate the results of this experiment and once again demonstrate the excellent application potential of AP in CA treatment. Furthermore, when comparing the changes of BP and blood lipids, we found that the BP improvement of patients in the study group was more significant, which also shows that AP + ATO is more suitable for EH patients with CA.…”

Section: Discussionsupporting

confidence: 87%

Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment

Jie-fang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The purpose of the study is to investigate the clinical efficacy and long-term prognosis of acupuncture (AP) combined with atorvastatin (ATO) in treating senile essential hypertension (EH) complicated with carotid atherosclerosis (CA). Methods. 108 elderly EH patients with CA admitted to our hospital between January 2018 and September 2018 were enrolled into the study, consisting of 67 patients who received treatment of AP with ATO (AP + ATO group) and 41 patients who received treatment of ATO alone (ATO group). Comparative outcomes included clinical efficacy, blood pressure (BP), the levels of blood lipids and inflammatory factors, carotid intima-media thickness (IMT), the number of unstable carotid intima plaques, the carotid plaque area, and the incidence of adverse reactions. All patients were followed up for 3 years to evaluate their quality of life and the recurrence rate of CA. Results. The AP + ATO group presented a higher efficacy, a declined BP, and lower posttreatment levels of blood lipids and inflammatory factors than the ATO group ( P < 0.05 ). Reductions were observed in IMT, number of plaques, and plaque area in both groups after treatment, with more significant improvements in the AP + ATO group ( P < 0.05 ). No difference was observed in the incidence of adverse reactions between two groups after treatment ( P > 0.05 ). The follow-up analysis demonstrated a higher SF-36 score and a lower recurrence rate of CA in the AP + ATO group than the ATO group ( P < 0.05 ). Conclusion. The findings suggested that, for elderly EH patients with CA, treatment of AP with ATO offers better clinical efficacy and safety, which not only can decline the BP, but also can reduce blood lipids and plaque formation, and improve quality of life.

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Section: Discussionsupporting

confidence: 87%

Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment

Jie-fang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The research group treated with ATO+ASP also showed higher ADL and lower NIHSS after treatment, indicating that combined treatment can significantly improve patients' ADL ability and reduce neurological deficits. In the research of Yu et al ATO+sodium ozagrel not only significantly inhibits inflammatory reactions in patients with type 2 diabetes mellitus complicated with lacunar infarction, but also alleviates neurological deficits, similar to our findings [24] . Another study reported that ATO calcium plus ASP is not only better than ASP alone in the treatment of patients with acute ischemic stroke, but also contributes to a lower incidence of complications and shorter hospitalization time, as In this study, the efficacy was compared between the conventional group receiving ASP therapy and the research group receiving ATO+ASP.…”

Section: Resultssupporting

confidence: 91%

Therapeutic Efficacy of Atorvastatin and Aspirin on Inflammatory Factors in Cerebral Venous Thrombosis

Shen,

Qiu,

2023

IJPS

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This paper primarily discusses about the influence of atorvastatin plus aspirin on efficacy and inflammatory factors in patients with cerebral venous thrombosis. The study participants comprised 240 cerebral venous thrombosis patients selected between January 2020 and June 2022 who were grouped as a conventional group (n=107) treated with aspirin and a research group (n=133) treated by atorvastatin+aspirin based on the therapy they received. Statistical and comparative analysis were made regarding the curative efficacy, adverse events (gastrointestinal discomfort, nausea, vomiting and dizziness), inflammatory factors (interleukin-6, tumor necrosis factor-alpha, procalcitonin, high-sensitivity C-reactive protein), platelet parameters (hematocrit, platelet adhesion rate), nerve function injury (National Institute of Health Stroke Scale) and activities of daily living. Based on the analysis results, the research group had a higher overall response rate, a lower complication rate and reduced inflammatory factors, platelet parameters and National Institute of Health Stroke Scale scores than the conventional group, as well as notably higher post-treatment activities of daily living, with statistical significance. From the above, it can be concluded that atorvastatin+aspirin is significantly effective in treating cerebral venous thrombosis, validly inhibiting inflammation, improving platelet parameters, alleviating neurological impairment and enhancing patients' activities of daily living.

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“…T2DM is a prevalent metabolic disease that is often accompanied by abnormal lipid metabolism and contributes to cerebrovascular diseases such as cerebral infarction ( 117 ). Recent research has shown that the combination of sodium ozagrel and atorvastatin can effectively reduce the inflammatory response, regulate HMGB1 levels, and regulate blood glucose and lipid levels in patients with T2DM and lacunar infarction ( 118 ). Another complication that commonly arises in diabetic patients is DN.…”

Section: Regulating Hmgb1 To Treat Diabetesmentioning

confidence: 99%

The relationship between HMGB1 and autophagy in the pathogenesis of diabetes and its complications

et al. 2023

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Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels and has become the third leading threat to human health after cancer and cardiovascular disease. Recent studies have shown that autophagy is closely associated with diabetes. Under normal physiological conditions, autophagy promotes cellular homeostasis, reduces damage to healthy tissues and has bidirectional effects on regulating diabetes. However, under pathological conditions, unregulated autophagy activation leads to cell death and may contribute to the progression of diabetes. Therefore, restoring normal autophagy may be a key strategy to treat diabetes. High-mobility group box 1 protein (HMGB1) is a chromatin protein that is mainly present in the nucleus and can be actively secreted or passively released from necrotic, apoptotic, and inflammatory cells. HMGB1 can induce autophagy by activating various pathways. Studies have shown that HMGB1 plays an important role in insulin resistance and diabetes. In this review, we will introduce the biological and structural characteristics of HMGB1 and summarize the existing knowledge on the relationship between HMGB1, autophagy, diabetes, and diabetic complications. We will also summarize potential therapeutic strategies that may be useful for the prevention and treatment of diabetes and its complications.

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Sodium ozagrel and atorvastatin for type 2 diabetes patients with lacunar cerebral infarction

Cited by 3 publications

References 45 publications

Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment

Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment

Therapeutic Efficacy of Atorvastatin and Aspirin on Inflammatory Factors in Cerebral Venous Thrombosis

The relationship between HMGB1 and autophagy in the pathogenesis of diabetes and its complications

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