Sodium NMR evaluation of articular cartilage degradation

Insko, Erik K.; Kaufman, Jonathan H.; Leigh, John S.; Reddy, Ravinder

doi:10.1002/(sici)1522-2594(199901)41:1<30::aid-mrm6>3.0.co;2-u

Cited by 74 publications

(42 citation statements)

References 13 publications

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“…Further improvements of the method will be to measure the relaxation times for each subject with fluid suppression for a better correction of the individual sodium maps because T1 and T2 (and T2*) are expected to change from healthy to osteoarthritis cartilage (35). These measurements should be acquired quickly by using undersampling and compressed sensing reconstruction to include them in the imaging protocol.…”

Section: Discussionmentioning

confidence: 99%

Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis

Madelin¹,

Babb²,

Xia³

et al. 2013

Radiology

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Purpose:To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T. Materials and Methods:The study was approved by the institutional review board and was compliant with HIPAA. The knee cartilage of 19 asymptomatic (control subjects) and 28 symptomatic (osteoarthritis patients) subjects underwent 7.0-T sodium MR imaging with use of two different sequences: one without fluid suppression (radial three-dimensional sequence) and one with fluid suppression (inversion recovery [IR] wideband uniform rate and smooth truncation [WURST]). Fluid suppression was obtained by using IR with an adiabatic inversion pulse (WURST pulse). Mean sodium concentrations and their standard deviations were measured in the patellar, femorotibial medial, and lateral cartilage regions over four consecutive sections for each subject. The minimum, maximum, median, and average means and standard deviations were calculated over all measurements for each subject. The utility of these measures in the detection of osteoarthritis was evaluated by using logistic regression and the area under the receiver operating characteristic curve (AUC). Bonferroni correction was applied to the P values obtained with logistic regression. Results:Measurements from IR WURST were found to be significant predicators of all osteoarthritis (Kellgren-Lawrence score of 1-4) and early osteoarthritis (Kellgren-Lawrence score of 1 or 2). The minimum standard deviation provided the highest AUC (0.83) with the highest accuracy (.78%), sensitivity (.82%), and specificity (.74%) for both all osteoarthritis and early osteoarthritis groups. Conclusion:Quantitative sodium MR imaging at 7.0 T with fluid suppression by using adiabatic IR is a potential biomarker for osteoarthritis.q RSNA, 2013

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Section: Discussionmentioning

confidence: 99%

Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis

Madelin¹,

Babb²,

Xia³

et al. 2013

Radiology

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“…Changes in sodium content and relaxation times using single quantum sodium MRI and TQF spectroscopy were investigated (148). Over a 50% PG depletion induced by trypsin from bovine cartilage, sodium content changed almost linearly and T 1 increased from 18 to 26 ms, T 2s increased from 7.5 to 12 ms and T 2f decreased from 2 to 1 ms.…”

Section: Sodium Mri Of Cartilage Fixed Charge Density (Fcd)mentioning

confidence: 99%

Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

et al. 2006

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In this article, both sodium magnetic resonance (MR) and T 1r relaxation mapping aimed at measuring molecular changes in cartilage for the diagnostic imaging of osteoarthritis are reviewed. First, an introduction to structure of cartilage, its degeneration in osteoarthritis (OA) and an outline of diagnostic imaging methods in quantifying molecular changes and early diagnostic aspects of cartilage degeneration are described. The sodium MRI section begins with a brief overview of the theory of sodium NMR of biological tissues and is followed by a section on multiple quantum filters that can be used to quantify both bi-exponential relaxation and residual quadrupolar interaction. Specifically, (i) the rationale behind the use of sodium MRI in quantifying proteoglycan (PG) changes, (ii) validation studies using biochemical assays, (iii) studies on human OA specimens, (iv) results on animal models and (v) clinical imaging protocols are reviewed. Results demonstrating the feasibility of quantifying PG in OA patients and comparison with that in healthy subjects are also presented. The section concludes with the discussion of advantages and potential issues with sodium MRI and the impact of new technological advancements (e.g. ultra-high field scanners and parallel imaging methods). In the theory section on T 1r , a brief description of (i) principles of measuring T 1r relaxation, (ii) pulse sequences for computing T 1r relaxation maps, (iii) issues regarding radio frequency power deposition, (iv) mechanisms that contribute to T 1r in biological tissues and (v) effects of exchange and dipolar interaction on T 1r dispersion are discussed. Correlation of T 1r relaxation rate with macromolecular content and biomechanical properties in cartilage specimens subjected to trypsin and cytokineinduced glycosaminoglycan depletion and validation against biochemical assay and histopathology are presented. Experimental T 1r data from osteoarthritic specimens, animal models, healthy human subjects and as well from osteoarthritic patients are provided. The current status of T 1r relaxation mapping of cartilage and future directions is also discussed. Copyright # 2006 John Wiley & Sons, Ltd. KEYWORDS: cartilage; arthritis; spin-lock; T1rho; sodium; MRI OSTEOARTHRITIS Osteoarthritis (OA) affects more than half of the population above the age of 65 (1,2) and has a significant negative impact on the quality of life of elderly individuals (3). The economic costs in the USA from OA have been estimated to be more than 1% of the gross domestic product (4). OA is now increasingly viewed as a metabolically active joint disorder of diverse etiologies. The biochemistry of the disease is characterized by the following changes in cartilage: reduced proteoglycan (PG) concentration, possible changes in the size of collagen fibril and aggregation of PG, increased water content and increased rate of synthesis and degradation of matrix macromolecules. The earliest changes in the cartilage due to OA result in a partial breakdown in the proteoglyc...

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“…However, T2 has been found to correlate poorly with PG content in controlled in vitro studies [30]. Sodium MRI has been reported as a noninvasive technique to quantitatively measure PG content in cartilage [7,19,23]. The method has been previously validated as an accurate measure of cartilage PG content as corroborated by independent measurements via spectrophotometric assay [33].…”

Section: Introductionmentioning

confidence: 99%

Detection of changes in articular cartilage proteoglycan by T_1ρ magnetic resonance imaging

Wheaton

Dodge

Borthakur

et al. 2005

Journal Orthopaedic Research

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The purpose of this work is to demonstrate the feasibility of TI,,-weighted magnetic resonance imaging (MRI) to quantitatively measure changes in proteoglycan content in cartilage. The TI, MRI technique was implemented in an in vivo porcine animal model with rapidly induced cytokine-mediated cartilage degeneration. Six pigs were given an intra-articular injection of recombinant porcine interleukin-1 p (IL-1 p) into the knee joint before imaging to induce changes in cartilage via matrix metalloproteinase (MMP) induction. The induction of MMPs by IL-1 was used since it has been extensively studied in many systems and is known to create conditions that mimic in part characteristics similar to those of osteoarthritis. The contralateral knee joint was given a saline injection to serve as an internal control. T1,-weighted MRI was performed on a 4 T whole-body clinical scanner employing a 2D fast spin-echo-based T I , imaging sequence. T I , relaxation parameter maps were computed from the TI,-weighted image series. The average TI,, relaxation rate, RIP (l/T,,) of the IL-lp-treated patellae was measured to be on average 25% lower than that of saline-injected patellae indicating a loss of proteoglycan. There was an average reduction of 49% in fixed charge density, measured via sodium MRI, of the IL-1 b-treated patellae relative to control corroborating the loss of proteoglycan. The effects of 1L-1 p, primarily loss of PG, were confirmed by histological and immunochemical findings. The results from this study demonstrate that R,,, is able to track proteoglycan content in vivo.

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Sodium NMR evaluation of articular cartilage degradation

Cited by 74 publications

References 13 publications

Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis

Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis

Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

Detection of changes in articular cartilage proteoglycan by T_1ρ magnetic resonance imaging

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Sodium NMR evaluation of articular cartilage degradation

Cited by 74 publications

References 13 publications

Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis

Articular Cartilage: Evaluation with Fluid-suppressed 7.0-T Sodium MR Imaging in Subjects with and Subjects without Osteoarthritis

Sodium and T1ρ MRI for molecular and diagnostic imaging of articular cartilage

Detection of changes in articular cartilage proteoglycan by T1ρ magnetic resonance imaging

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Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

Detection of changes in articular cartilage proteoglycan by T_1ρ magnetic resonance imaging