Sodium MRI radiofrequency coils for body imaging

Bangerter, Neal K.; Kaggie, Joshua D.; Taylor, Meredith D.; Hadley, J. Rock

doi:10.1002/nbm.3392

Cited by 25 publications

(23 citation statements)

References 60 publications

(90 reference statements)

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“…Thus, separate X‐nuclei coils are necessary to transmit and receive signals in X‐nuclei MRI. Different Na setups have been reviewed for applications in the head, the heart, and in the body . The latest developments in RF coils for X‐nuclei imaging focus on setups comprising multiple transmit‐and‐receive coils, especially for 23 Na MRI .…”

Section: Current State and Technical Challengesmentioning

confidence: 99%

X‐nuclei imaging: Current state, technical challenges, and future directions

Kleimaier

Malzacher

et al. 2019

Magnetic Resonance Imaging

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1H imaging is concerned with contrast generation among anatomically distinct soft tissues. X‐nuclei imaging, on the other hand, aims to reveal the underlying changes in the physiological processes on a cellular level. Advanced clinical MR hardware systems improved 1H image quality and simultaneously enabled X‐nuclei imaging. Adaptation of 1H methods and optimization of both sequence design and postprocessing protocols launched X‐nuclei imaging past feasibility studies and into clinical studies. This review outlines the current state of X‐nuclei MRI, with the focus on 23Na, 35Cl, 39K, and 17O. Currently, various aspects of technical challenges limit the possibilities of clinical X‐nuclei MRI applications. To address these challenges, quintessential physical and technical concepts behind different applications are presented, and the advantages and drawbacks are delineated. The working process for methods such as quantification and multiquantum imaging is shown step‐by‐step. Clinical examples are provided to underline the potential value of X‐nuclei imaging in multifaceted areas of application. In conclusion, the scope of the latest technical advance is outlined, and suggestions to overcome the most fundamental hurdles on the way into clinical routine by leveraging the full potential of X‐nuclei imaging are presented. Level of Evidence: 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:355–376.

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Section: Current State and Technical Challengesmentioning

confidence: 99%

X‐nuclei imaging: Current state, technical challenges, and future directions

Kleimaier

Malzacher

et al. 2019

Magnetic Resonance Imaging

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“…38 Many different coil designs, optimized for improved sodium sensitivity, have been developed and reported in the literature recently, suitable for almost all body parts, such as the knee, the breast, and the brain. 10,11,[39][40][41][42][43][44][45]…”

Section: Quantitative Sodium Mrimentioning

confidence: 99%

Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging

Zaric

Juráš

Szomolányi

et al. 2020

Magnetic Resonance Imaging

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Sodium magnetic resonance imaging ( 23 Na-MRI) is a highly promising imaging modality that offers the possibility to noninvasively quantify sodium content in the tissue, one of the most relevant parameters for biochemical investigations. Despite its great potential, due to the intrinsically low signal-to-noise ratio (SNR) of sodium imaging generated by low in vivo sodium concentrations, low gyromagnetic ratio, and substantially shorter relaxation times than for proton ( 1 H) imaging, 23 Na-MRI is extremely challenging. In this article, we aim to provide a comprehensive overview of the literature that has been published in the last 10-15 years and which has demonstrated different technical designs for a range of 23 Na-MRI methods applicable for disease diagnoses and treatment efficacy evaluations. Currently, a wider use of 3.0T and 7.0T systems provide imaging with the expected increase in SNR and, consequently, an increased image resolution and a reduced scanning time. A great interest in translational research has enlarged the field of sodium MRI applications to almost all parts of the body: articular cartilage tendons, spine, heart, breast, muscle, kidney, and brain, etc., and several pathological conditions, such as tumors, neurological and degenerative diseases, and others. The quantitative parameter, tissue sodium concentration, which reflects changes in intracellular sodium concentration, extracellular sodium concentration, and intra-/extracellular volume fractions is becoming acknowledged as a reliable biomarker. Although the great potential of this technique is evident, there must be steady technical development for 23 Na-MRI to become a standard imaging tool. The future role of sodium imaging is not to be considered as an alternative to 1 H MRI, but to provide early, diagnostically valuable information about altered metabolism or tissue function associated with disease genesis and progression. Level of Evidence: 1 Technical Efficacy Stage: 1

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“…Of the X-nuclei, array coil usage has perhaps been most commonly implemented for 23 Na studies [112]. The very first use of an array coil for Na imaging was by Bottomley et al who used a frequency-translation approach with a 4-channel 23 Na array [43] and reported 300-400% increases in SNR in certain voxels compared to a single-channel comparison coil.…”

Section: Emerging Topicsmentioning

confidence: 99%

A Review of Non-¹H RF Receive Arrays in Magnetic Resonance Imaging and Spectroscopy

Wilcox

Wright

McDougall

2020

IEEE Open J. Eng. Med. Biol.

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It is now common practice to use radiofrequency (RF) array coils to increase the signal-to-noise ratio (SNR) in 1 H magnetic resonance imaging and spectroscopy experiments. Use of array coils for non-1 H experiments, however, has been historically more limited despite the fact that these nuclei suffer inherently lower sensitivity and could benefit greatly from an increased SNR. Recent advancements in receiver technology and increased support from scanner manufacturers have now opened greater options for the use of array coils for non-1 H magnetic resonance experiments. This paper reviews the research in adopting array coil technology with an emphasis on studies of the most commonly studied non-1 H nuclei including 31 P, 13 C, 23 Na, and 19 F. These nuclei offer complementary information to 1 H imaging and spectroscopy and have proven themselves important in the study of numerous disease processes. While recent work with non-1 H array coils has shown promising results, the technology is not yet widely utilized and should see substantial developments in the coming years.

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Sodium MRI radiofrequency coils for body imaging

Cited by 25 publications

References 60 publications

X‐nuclei imaging: Current state, technical challenges, and future directions

X‐nuclei imaging: Current state, technical challenges, and future directions

Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging

A Review of Non-¹H RF Receive Arrays in Magnetic Resonance Imaging and Spectroscopy

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Sodium MRI radiofrequency coils for body imaging

Cited by 25 publications

References 60 publications

X‐nuclei imaging: Current state, technical challenges, and future directions

X‐nuclei imaging: Current state, technical challenges, and future directions

Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging

A Review of Non-1H RF Receive Arrays in Magnetic Resonance Imaging and Spectroscopy

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Product

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A Review of Non-¹H RF Receive Arrays in Magnetic Resonance Imaging and Spectroscopy