Sodium metavanadate treatment improves glycogen levels in multiple tissues in a model of metabolic syndrome caused by chronic cadmium exposure in Wistar rats

Sarmiento-Ortega, Víctor Enrique; Moroni-González, Diana; Díaz, Alfonso; Morán, Carolina; Brambila, Eduardo; Treviño, Samuel

doi:10.1007/s10534-020-00276-8

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…Moreover, the mRNA expression levels of genes related to fatty acid transport and lipolysis, including Apoa1, Fabp4, Fabp5, Atgl, Hsl, and Ucp2 were also remarkably up-regulated. In agreement with previous studies [ 45 , 46 ], our study also showed that VOdipic-Cl improves liver lipid metabolism disorders by down-regulating the expression of PPARγ, C/EBPa, SREBP-1c and FAS proteins related to lipid synthesis. It has been reported that esterification of FFA to TG and β-oxidation of FFAs are two main metabolic pathways of FFAs in the liver [ 47 ].…”

Section: Discussionsupporting

confidence: 93%

Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation

Wang

Chen

et al. 2022

Antioxidants

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Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. The aim of this study is to investigate the protective effects and the underlying mechanisms of vanadium(IV)-chlorodipicolinate ([VIVO(dipic-Cl)(H2O)2, VOdipic-Cl]) in a mouse model of NAFLD induced by a high-fat diet (HFD). VOdipic-Cl (10 mg/kg/day body weight) treatment for 4 weeks significantly controlled body weight gain, and effectively reduced the increase in serum and hepatic triglyceride (TG) and total cholesterol (TC) levels, mitigated pathological injury, decreased malondialdehyde (MDA) level, and inhibited endoplasmic reticulum (ER) stress and inflammatory response in the livers of C57BL/6 obese mice. Moreover, RNA-sequencing analysis revealed distinct transcriptional profiles with differentially expressed genes (DEGs) in livers. We found that VOdipic-Cl effectively down-regulated genes related to lipid synthesis and up-regulated genes related to fatty acid transport and lipolysis, and down-regulated the expression of genes related to ER stress and immune response in the livers of obese mice. In conclusion, VOdipic-Cl effectively prevented hepatic steatosis by controlling body weight, mitigating oxidative stress, and regulating the expression of genes related to lipid metabolism, ER stress and immune response, which provides new insights into the molecular mechanism of the protective effect of VOdipic-Cl against hepatic steatosis.

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Section: Discussionsupporting

confidence: 93%

Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation

Wang

Chen

et al. 2022

Antioxidants

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“…In hyperglycemic states associated with insulin resistance, GSK3β is overactivated, which impedes glycogen synthesis. Likewise, Cd exposure seems to be an inductor of the activity of GSK3β or an inhibitor of GS because animals exposed to a chronic environmental LOAEL dose show insulin resistance and continuous reduction in hepatic glycogen levels [ 77 , 135 , 156 , 157 ].…”

Section: Cadmium Impairs Hepatic Glucose Homeostasismentioning

confidence: 99%

“…In white adipose tissue (WAT), Cd accumulation is also dose- and time-dependent [ 135 , 156 ]. Different concentrations of subcutaneous Cd administrations (3.5 times/week) for two weeks showed Cd accumulation in epididymal adipose tissue and abnormal adipocyte differentiation, expansion, and function [ 209 , 210 ].…”

Section: Cadmium and Adipose Tissuementioning

confidence: 99%

“…Similar results have been found in chronic Cd exposure at LOAEL dose for five months. Male Wistar rats show a higher body weight, abdominal perimeter, BMI, and fat percentage, when exposed to an LOAEL dose from early-life stage [ 156 ]. However, young adult female and male rats exposed to a subacute and acute oral environmental amount of Cd resulted in low body weight, the delta of weight gain, and abdominal perimeter [ 131 , 268 ].…”

Section: Cadmium and Obesitymentioning

confidence: 99%

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Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

Moroni-González

Sarmiento-Ortega

Díaz

et al. 2023

Toxics

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Cadmium has been well recognized as a critical toxic agent in acute and chronic poisoning cases in occupational and nonoccupational settings and environmental exposure situations. Cadmium is released into the environment after natural and anthropogenic activities, particularly in contaminated and industrial areas, causing food pollution. In the body, cadmium has no biological activity, but it accumulates primarily in the liver and kidney, which are considered the main targets of its toxicity, through oxidative stress and inflammation. However, in the last few years, this metal has been linked to metabolic diseases. The pancreas–liver–adipose axis is largely affected by cadmium accumulation. Therefore, this review aims to collect bibliographic information that establishes the basis for understanding the molecular and cellular mechanisms linked to cadmium with carbohydrate, lipids, and endocrine impairments that contribute to developing insulin resistance, metabolic syndrome, prediabetes, and diabetes.

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“…Heavy metal ions as the main environmental contaminants in water systems cause great harm to human beings and different species of organisms throughout the world 1‐3 . Among these heavy metal ions, cadmium ions are highly toxic to human beings and lead to serious damage to the nervous system, kidney and liver, causing metabolic disorders and other related diseases 4‐6 . Cd 2+ is a priority pollutant and tolerable Cd 2+ concentrations in water are limited as 27 nmol L −1 due to the strong toxic role of cadmium ions 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of neodymium vanadate nanoribbons and its application to highly efficient determination of cadmium ions

Cong,

Wang,

Feng

et al. 2023

J of Chemical Tech & Biotech

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BACKGROUNDCadmium ions may be discarded to the environment with living organisms from fossil fuel combustion, phosphate fertilizer and battery industries. It is urgent and essential to develop a sensitive and rapid method for monitoring Cd2+ level in aquatic environments and biological systems. Neodymium vanadate possesses good catalytic performance for the electrocatalysis of heavy metal ions. Single crystalline Nd vanadate nanoribbons were obtained by a facile approach and used as electrode materials for electrochemical detection of Cd2+.RESULTSThe Nd nanoribbons with tetragonal NdVO4 phase possess length, width and thickness of longer than 10 μm, 200 nm to 1.5 μm and 50 nm, respectively. Nd vanadate nanoribbons can serve as a good electron transfer interface. An anodic peak is located at +0.56 V at the Nd vanadate nanoribbon‐modified electrode in 0.1 mol L−1 KCl electrolyte containing 1 mmol L−1 Cd2+ by square wave voltammetry technique. The Nd vanadate nanoribbon‐modified electrode exhibits a linear range of 0.01–1000 μmol L−1 and a detection limit of 0.29 nmol L−1, with good stability, reproducibility and selectivity for Cd2+ detection.CONCLUSIONThe optimal measurement conditions including the pH value of the KCl solution, deposition time, deposition potential and standing time, which are pH 1, 180 s, −1.0 V and 60 s, respectively. The Nd vanadate nanoribbon‐modified electrode shows great application potential for detecting heavy metal ions in liquid environments. © 2023 Society of Chemical Industry.

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Sodium metavanadate treatment improves glycogen levels in multiple tissues in a model of metabolic syndrome caused by chronic cadmium exposure in Wistar rats

Cited by 11 publications

References 51 publications

Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation

Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation

Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

Facile synthesis of neodymium vanadate nanoribbons and its application to highly efficient determination of cadmium ions

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