Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis

Blaustein, M. P.

doi:10.1152/ajpcell.1977.233.5.c189-r

Cited by 236 publications

(304 citation statements)

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“…One is that the changes in intracellular ionic concentrations are directly responsible for the changes in vascular tone. For example, the increased Na+/H + antiport exchange could lead to raised intracellular Na +, hence raised intracellular Ca 2 + by increased Na +/Ca 2 + exchange [27,28]. Also, intracellular alkalinisation can directly enhance vascular contractility [29] by increased Ca 2 § dulin interaction [30] or increased generation of diacylglycerol in angiotensin-stimulated smooth muscle cells [31].…”

Section: Discussionmentioning

confidence: 99%

Leucocyte Na+/H+ antiport activity in Type 1 (insulin-dependent) diabetic patients with nephropathy

Simmons²,

Frighi³

et al. 1990

Diabetologia

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Section: Discussionmentioning

confidence: 99%

Leucocyte Na+/H+ antiport activity in Type 1 (insulin-dependent) diabetic patients with nephropathy

Simmons²,

Frighi³

et al. 1990

Diabetologia

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“…If Na+{-Ca2+ exchange is the major determinant of [Ca2+]i, this would result in an increase in basal [Ca2+]i and tension development. (Blaustein, 1977;Abbott, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…Although the resulting equilibrium thermodynamic relationship between these gradients has long been appreciated , the physiological significance of the exchange process in many of the various types of cell where it has been observed has remained unclear (van Breemen, Aaronson & Loutzenhiser, 1979;Eisner & Lederer, 1985). It has been suggested, for example, that Na+-Ca2+ exchange is crucial in linking a defect in Na+ metabolism to increased vascular resistance (Blaustein, 1977), but also that the exchange plays little or no part in cellular Ca2+ homeostasis in smooth muscle (Droogmans & Casteels, 1979;Aaronson & van Breemen, 1981; Mulvany, Aalkjaer .…”

Section: Introductionmentioning

confidence: 99%

Alterations in [Ca2+]i mediated by sodium‐calcium exchange in smooth muscle cells isolated from the guinea‐pig ureter.

Aaronson

Benham

1989

The Journal of Physiology

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“…23 Also, in more severe hypertensives, abnormal sodium-dependent transport pathways in the cell or its organelles may alter calcium availability, which in turn may affect contractility in vascular smooth muscle. 24 Alternatively, it is possible that drug treatment raises countertransport levels, e.g., as a response to reduced serum potassium. It would be of relevance in future studies to attempt to relate efflux levels to parameters reflecting possible physiologic mechanisms, such as peripheral resistance.…”

Section: Discussionmentioning

confidence: 99%

Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.

Trevisan

Ostrow²,

Cooper³

et al. 1983

Hypertension

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SUMMARY A population-based survey of 134 white men, recruited from the Chicago People's Gas Company labor force, was carried out to examine the association between sodium-lithium (Na-Li) countertransport and hypertension. Of the 134 participants in this industry-sponsored periodic health examination, 64 were normotensive and 70 were either taking antihypertensive medications or had a systolic pressure 3= 140 or a diastolic pressure 2= 90 mm Hg. The hypertensives were older and more overweight. Countertransport was significantly higher in hypertensives than in normotensives. Among the three subgroups of hypertensives -untreated borderline (140/90 to 160/95 mm Hg), untreated definite (over 160/95 mm Hg), and treated -an increase in countertransport was consistently observed, significant for the latter two groups. The relationship between countertransport and hypertension was independent of overweight, with countertransport being significantly related to both blood pressure and overweight. Altered ion transport may play an important role in the etiology and/or pathophysiology of hypertension. (Hypertension 5:363-367, 1983) KEY WORDS • countertransport • sodium metabolism • blood pressure R ED blood cell sodium-dependent membrane processes are currently being studied in relation to the etiology and pathogenesis of hypertension. 1 " 14 Previous case control studies have demonstrated a relationship between sodium-lithium (Na-Li) countertransport and hypertension.'-7 -15~17 This report described the results of a populationbased cross-sectional survey in employed white men relating levels of countertransport to the presence of hypertension. Methods Data CollectionVolunteers for this study were male employees (the great majority of whom were white) of the Chicago People's Gas Company participating in the companysponsored periodic health examination. The participation rate in this examination is over 90%. l8 During the period from June 1981 to December 1981, on a semi weekly basis, without selection the first four employees who presented at the company medical office for their regularly scheduled examination were invited to participate; response rate was 100%.A nurse measured blood pressure after the man had rested quietly in the sitting position for 5 minutes. Korotkoff sounds phases I and V were recorded from a single reading with a standard mercury sphygmomanometer. While blood was being sampled for routine laboratory analyses, an additional 15 cc of venous blood was collected in plastic tubes containing ammonium heparin. Samples were collected in the fasting state before 10 a.m. With the man in indoor clothes, with shoes off, height and weight were measured on a balance scale. Medical history was obtained through the use of a self-administered questionnaire.Of 157 white men participating in the study, 21 were excluded from this report because of a major illness (renal, hormonal, psychiatric) thought to influence intracellular ion metabolism. 6 l9 -2I In addition, two participants were excluded because of extremely...

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Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis

Cited by 236 publications

References 0 publications

Leucocyte Na+/H+ antiport activity in Type 1 (insulin-dependent) diabetic patients with nephropathy

Leucocyte Na+/H+ antiport activity in Type 1 (insulin-dependent) diabetic patients with nephropathy

Alterations in [Ca2+]i mediated by sodium‐calcium exchange in smooth muscle cells isolated from the guinea‐pig ureter.

Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.

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