Sodium Fluoride and Fluoride Contaminated Ground Water Induced Altered Reproductive Performances in Male Rats

Chaithra, B; Sarjan, Halugudde Nagaraja; Shivabasavaiah,

doi:10.1007/s12011-019-01882-5

Cited by 13 publications

(6 citation statements)

References 18 publications

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“… 23 Fluoride-induced reductions in T levels and sperm motility have been detected in male rats, as described in a literature review. 24 Fluoride-induced OS has been reported to cause impaired antioxidant defense systems, mitochondrial dysfunction, and genotoxicity in animal models, and antioxidant intervention might be affected by antioxidants. 24 25 However, fluorine-induced male reproductive toxicity and GST polymorphisms have not been elucidated in humans.…”

Section: Discussionmentioning

confidence: 99%

“… 24 Fluoride-induced OS has been reported to cause impaired antioxidant defense systems, mitochondrial dysfunction, and genotoxicity in animal models, and antioxidant intervention might be affected by antioxidants. 24 25 However, fluorine-induced male reproductive toxicity and GST polymorphisms have not been elucidated in humans. Our findings reveal that sperm parameters and the spermatogenesis process are directly associated with male residency in fluorosis-endemic areas.…”

Section: Discussionmentioning

confidence: 99%

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Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility

Liu

et al. 2022

Asian Journal of Andrology

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Male infertility caused by idiopathic oligoasthenospermia (OAT) is known as idiopathic male infertility. Glutathione S-transferase (GST) and fluoride may play important roles in idiopathic male infertility, but their effects are still unknown. Our study examined the relationship between GST polymorphisms and fluoride-induced toxicity in idiopathic male infertility and determined the underlying mechanism. Sperm, blood, and urine samples were collected from 560 males. Fluoride levels were measured by a highly selective electrode method, and GST genotypes were identified using polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP). Semen parameters, DNA fragmentation index (DFI), mitochondrial membrane potential (MMP), and oxidative stress (OS) biomarkers were statistically assessed at the P < 0.05 level. Compared with healthy fertile group, semen parameters, fluoride levels, OS biomarkers, sex hormone levels, and MMP and DFI levels were lower in the idiopathic male infertility group. For glutathione S-transferase M1 (GSTM1[-]) and glutathione S-transferase T1 (GSTT1[-]) or glutathione S-transferase P1 (GSTP1) mutant genotypes, levels of semen fluoride, OS, MMP, and DFI were considerably higher, and the mean levels of sperm parameters and testosterone were statistically significant in GSTM1(+), GSTT1(+), and GSTP1 wild-type genotypes. Both semen and blood fluoride levels were associated with oxidative stress in idiopathic male infertility patients. Elevated fluoride in semen with the genotypes listed above was linked to reproductive quality in idiopathic male infertility patients. In conclusion, GST polymorphisms and fluorine may have an indicative relationship between reproductive quality and sex hormone levels, and OS participates in the development of idiopathic male infertility.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility

Liu

et al. 2022

Asian Journal of Andrology

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“…Fluoride-induced sperm quality changes have been seen in vivo and in vitro in many species, such as guinea pig, rats, chicken and rabbit (18). Experimental outcomes vary, however, some studies suggest that spermatogenesis in rats is not affected by exposure to sodium fluoride (19), on the other hand, experimental studies propose that low sperm quality and quantity may be caused by giving fluoride leading to reduced fertility (20). A fall in sperm viability and a high occurrence in sperm abnormality were obtained in the current study of the treated groups with 150, 300 ppm of NaF for 90 days and subsequent findings were recorded by several researchers (21).…”

Section: Discussionmentioning

confidence: 99%

Effects of Sub Lethal Concentrations of Sodium Fluoride on Sperm Activity and on the level of Sex Hormones of Adult Male Albino Rats

Al-Sabaawy¹,

Al-Kaisie²

2020

Iraqi J. Vet. Med.

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In recent years, fluorosis caused many problems in humans and animals bodies. Dental fluorosis, skeletal fluorosis, bone fractures, decreased birth rates, adverse effects on the male genital system, like damaging the structure of testes and epididymis and loosing fertilization ability can be considered as good examples of fluorosis. Thus, the current study aimed to determine the toxicity of sodium fluoride (NaF) on the activity of sperm and the level of sex hormones including testosterone, follicle stimulating hormone, and luteinizing hormone. For achieving this purpose, thirty adult albino male rats, aged between 90-100 days, were divided randomly into two treated groups with 10 rats for each group which were treated with 150, 300 ppm of sodium fluoride,respectively. In addition, 10 rats were kept as a control group. Sodium fluoride was offered to the treated groups in the drinking water to evaluate the toxic effect of NaF on male reproductive system, sperm concentration, sperm motion, and sperm velocity compared with control group. The findings revealed a significant decrease in the sperm concentration, sperm count, sperm motion, sperm velocity and the level of sexual hormones in comparison with the control group. It can be concluded that NaF may reduce the efficiency of male reproductive system, and reduce the levels of sexual hormones in rats

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“…It has the potential to be used as a natural remedy for curing and preventing many disorders [15] . Several studies have explored the potential beneficial effects of curcumin on male hormone levels, testicular cells, and sperm parameters [16,17] . Therefore, we aimed to investigate the effect of lead on the structure and functions of the tesis, and compare the influence of Selenium and Curcumin in the case of oral combination with Lead to alleviate the possible testiculartoxicity caused by Lead exposure in male albino rats through histological, immunohistochemical and biochemical parameters.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]

Abdel Hady,

Abd-Allah,

Emam

et al. 2023

International Journal of Medical Arts

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Article informationBackground: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help to counteract this toxicity. Aim of the work:We investigated the possible role of Selenium or curcumin in improving the testicular toxicity caused by the intake of Lead orally in albino rats.Materials and Methods: 40 adult male albino rats were selected and unsystematically separated into 4 groups [10 rats/each] included: Group 1: control group; Group 2: Pb-exposed group; Group 3: Pb plus Selenium and Group 4: Pb plus Curcumin. Blood samples were collected for examination of serum biochemical parameters, serum Testosterone, LH, FSH levels, Total Anti-oxidant Capacity [TAC], testicular tissue oxidative stress parameters and testicular histology were evaluated.Results: Oral administration of Pb to rats for 4 weeks disturbs the testicular structure and function with a significant increase in the oxidative stress enzymes, deposition of collagen fibers and anticaspase-3 in the testis. While, administration of either Selenium or Curcumin with Pb-exposure induced significant improvement of all the testicular changes. Conclusion:Chronic lead exposure causes deteriorating changes in the testicular structures and functions which could be improved by oral intake of either Selenium or Curcumin by their antioxidant, antifibrotic, and antiapoptotic properties.

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Sodium Fluoride and Fluoride Contaminated Ground Water Induced Altered Reproductive Performances in Male Rats

Cited by 13 publications

References 18 publications

Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility

Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility

Effects of Sub Lethal Concentrations of Sodium Fluoride on Sperm Activity and on the level of Sex Hormones of Adult Male Albino Rats

Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]

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