Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways

Luo, Min; Chen, Pan-pan; Yang, Lu; Wang, Peng; Lu, Yanliu; Shi, Fuguo; Gao, Yang; Xu, Shang‐Fu; Gong, Qihai; Xu, Rui‐Xia; Deng, Jiang

doi:10.1016/j.biopha.2019.108735

Cited by 20 publications

(19 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed that the CaSR-mediated and PKC-MAPK signaling pathways were involved in the anti-hypertrophic effects of SF (Figure 8). These findings are consistent with our previous experimental results in a rat model of myocardial hypertrophy induced by abdominal aortic coarctation (Luo et al, 2019). In a follow-up study, we will design cellular experiments to determine the specific mechanism of SF, used the inhibitors of CaSR-mediated signaling pathway and the inhibitors of PKC-MAPK signaling pathway.…”

Section: Discussionsupporting

confidence: 87%

“…For several decades, SF has been widely used in China to treat cardiovascular and cerebrovascular diseases and to prevent thrombosis (Wang and Ou-Yang, 2005). Our previous study showed that SF alleviates myocardial hypertrophy induced by coarctation of the abdominal aorta (Luo et al, 2019). In this study, we evaluated the pharmacological effects of SF on cardiac remodeling in spontaneously hypertensive rats (SHRs) and the underlying mechanisms, focusing on the signaling pathway mediated by CaSR.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway

et al. 2021

Self Cite

View full text Add to dashboard Cite

As a common complication of many cardiovascular diseases, cardiac hypertrophy is characterized by increased cardiac cell volume, reorganization of the cytoskeleton, and the reactivation of fetal genes such as cardiac natriuretic peptide and β-myosin heavy chain. Cardiac hypertrophy is a distinguishing feature of some cardiovascular diseases. Our previous study showed that sodium ferulate (SF) alleviates myocardial hypertrophy induced by coarctation of the abdominal aorta, and these protective effects may be related to the inhibition of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) signaling pathways. This study investigated the inhibitory effect and mechanism of SF on myocardial hypertrophy in spontaneously hypertensive rats (SHRs). The effects of SF on cardiac hypertrophy were evaluated using echocardiographic measurement, pathological analysis, and detection of atrial natriuretic peptide (ANP) and β-myosin heavy chain (β-MHC) expression. To investigate the mechanisms underlying the anti-hypertrophic effects of SF, the calcium-sensing receptor (CaSR), calcineurin (CaN), nuclear factor of activated T cells 3 (NFAT3), zinc finger transcription factor 4 (GATA4), protein kinase C beta (PKC-β), Raf-1, extracellular signal-regulated kinase 1/2 (ERK 1/2), and mitogen-activated protein kinase phosphatase-1 (MKP-1) were detected by molecular biology techniques. Treatment with SF ameliorated myocardial hypertrophy in 26-week-old SHRs. In addition, it downregulated the levels of ANP, β-MHC, CaSR, CaN, NFAT3, phosphorylated GATA4 (p-GATA4), PKC-β, Raf-1, and p-ERK 1/2; and upregulated the levels of p-NFAT3 and MKP-1. These results suggest that the effects of SF on cardiac hypertrophy are related to regulation of the CaSR-mediated signaling pathway.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…We made a rat model of MH by abdominal aortic constriction operation as described previously [ 11 ] with a few modifications. The animals were randomly divided into two groups: (1) the sham operation (sham) group ( n = 30), in which the surgical procedure of AAC was performed in the same way except for ligation of the abdominal aorta, and (2) the AAC group ( n = 40), in which the surgical procedure of AAC was performed by ligation of the abdominal aorta 5 mm above the branching of the right renal artery to induce pressure overload of the heart.…”

Section: Methodsmentioning

confidence: 99%

Cholecystokinin Expression in the Development of Myocardial Hypertrophy

Han

et al. 2021

Scanning

View full text Add to dashboard Cite

Background. Expression of cholecystokinin is found in myocardial tissues as a gastrointestinal hormone and may be involved in cardiovascular regulation. However, it is unclear whether there is an increase in cholecystokinin expression in myocardial hypertrophy progression induced by abdominal aortic constriction. The study is aimed at exploring the relationship between cholecystokinin expression and myocardial hypertrophy. Methods. We randomly divided the 70 Sprague-Dawley rats into two groups: the sham operation group and the abdominal aortic constriction group. The hearts of rats were measured by echocardiography, and myocardial tissues and blood were collected at 4 weeks, 8 weeks, and 12 weeks after surgery. Morphological changes were assessed by microscopy. The cholecystokinin expression was evaluated by immunochemistry, Western blotting, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay. Results. The relative protein levels of cholecystokinin were significantly increased in the abdominal aortic constriction groups compared with the corresponding sham operation groups at 8 weeks and 12 weeks. The cholecystokinin mRNA in the abdominal aortic constriction groups was significantly higher than the time-matched sham operation groups. Changes in the left ventricular wall thickness were positively correlated with the relative protein levels of cholecystokinin and the mRNA of cholecystokinin. Conclusions. The development of myocardial hypertrophy can affect the cholecystokinin expression of myocardial tissues.

show abstract

“…In another study, Wang et al 36 discovered that ester constituents of CX concentration dependently ameliorated myocardial ischemia injury in rats, as manifested by a reduction of the infarction size, a decrease in the serum levels of cardiac enzymes and an improvement of pathological changes through activation of the PI3K/Akt/mTOR signaling pathway. Luo et al 37 investigated sodium ferulate (SF) inhibition in a rat model of myocardial hypertrophy induced by coarctation of the abdominal aorta and discovered that SF alleviated such myocardial hypertrophy (induced by coarctation of the abdominal aorta), and these protective effects could be related to the inhibition of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) signaling pathways. Further studies 38 demonstrated that a CX ethyl acetate (EA) extract showed strong activity against thrombin (THR) and butanol extract (BA) was more effective in inhibiting factor Xa (FXa) activity, being beneficial to thromboembolic disease.…”

Section: Pharmacological Effects Of CXmentioning

confidence: 99%

The combination of two natural medicines, Chuanxiong and Asarum: A review of the chemical constituents and pharmacological activities

Yang

Shen

Zhang

et al. 2021

Journal of Chemical Research

View full text Add to dashboard Cite

Traditional Chinese medicine has been clinically used in China for many years, with experimental studies and clinical trials having demonstrated that it is safe and valid. Among many traditional natural medicines, Chuanxiong and Asarum have been proven to be effective in the treatment of relieving pain. Actually, as well as analgesic, they have common attributes, such as anti-inflammatory, cardiovascular benefits, and anticancer activities, with volatile oils being their major components. Furthermore, Chuanxiong and Asarum have been combined as drug pairs in the same prescription for thousands of years, with examples being Chuanxiong Chatiao San and Chuanxiongxixintang. More interestingly, their combination has better therapeutic effects on diseases than a single drug. After the combination of Chuanxiong and Asarum forms a blend, a series of changes take place in their chemical components, such as the contents of the main active ingredients, ferulic acid and ligustilide, increased significantly after this progress. At the same time, the pharmacological effects of the combination appearing to be more powerful, such as synergistic analgesic. This review focuses on the chemical constituents and pharmacological activities of Chuanxiong, Asarum, and Chuanxiong Asarum compositions.

show abstract

Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways

Cited by 20 publications

References 34 publications

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway

Cholecystokinin Expression in the Development of Myocardial Hypertrophy

The combination of two natural medicines, Chuanxiong and Asarum: A review of the chemical constituents and pharmacological activities

Contact Info

Product

Resources

About