Sodium Dodecyl Sulfate (SDS)-Loaded Nanoporous Polymer as Anti-Biofilm Surface Coating Material

Abstract

Biofilms cause extensive damage to industrial settings. Thus, it is important to improve the existing techniques and develop new strategies to prevent bacterial biofilm formation. In the present study, we have prepared nanoporous polymer films from a self-assembled 1,2-polybutadiene-b-polydimethylsiloxane (1,2-PB-b-PDMS) block copolymer via chemical cross-linking of the 1,2-PB block followed by quantitative removal of the PDMS block. Sodium dodecyl sulfate (SDS) was loaded into the nanoporous 1,2-PB from aqueous solution. The SDS-loaded nanoporous polymer films were shown to block bacterial attachment in short-term (3 h) and significantly reduce biofilm formation in long-term (1 week) by gram-negative bacterium Escherichia coli. Tuning the thickness or surface morphology of the nanoporous polymer films allowed to extent the anti-biofilm capability.

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

“…Surface engineering of materials can enhance device biocompatibility and functionality and material properties and surfaces can be modified to reduce microbial contamination and prevent biofilm infections. The different methodologies used includeantifouling coatings [47],antiadhesive surface modifications [109],addition of antimicrobials to the surfaces of medical devices [110–112],coating devices with polymer products [113],surface engineering with chemical moieties [57, 114–116],coating, lamination, adsorption, or immobilization of biomolecules [117–119]. …”

Interspecific diversity reduces and functionally substitutes for intraspecific variation in biofilm communities

“…To investigate this, biofilms with different levels and types of diversity were established and treated with the anionic surfactant SDS, a general stressor that has been widely used to test the performance of biofilms (Barraud et al, 2006;Nett et al, 2008;Li et al, 2013;Lee et al, 2014). The biofilms tested include monotypic biofilm populations established with isolates (P. aeruginosa SCV, K. pneumoniae NMV, P. protegens SCV and CCV) that do not self-generate additional morphotypic variants (Supplementary Figure S1), polytypic biofilm populations established with wild-type strains that Significantly different from the parental strain with Po0.05, Tukey's honest significance test test.…”

Tunable, antibacterial activity of silicone polyether surfactants

“…A 0.1 (w/v%) stock solution of SDS in autoclaved PBS was used as a positive control to gauge the efficacy of each surfactant as a potential antibacterial agent: SDS is a highly potent anionic surfactant known to exhibit antibacterial activity [22,23] at concentrations ≥0.1% [24]. Negative controls included the use of 0.1% poly(ethylene glycol) methyl ether (PEG) (i.e., the backbone of the surfactants minus the 'active' silicone head group), and E. coli growing in the absence of any treatment.…”