Sodium dodecyl sulfate improved stability and transdermal delivery of salidroside-encapsulated niosomes via effects on zeta potential

Zhang, Yongtai; Qian, Jing; Hu, Hsiao Yun; He, Zhiyao; Wu, Tong

doi:10.1016/j.ijpharm.2020.119183

Cited by 54 publications

(31 citation statements)

References 25 publications

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“…This can account for the increase in EE with K7. Decrease after 60 min is similar to what Mavaddati et al ( 2015 ) observed and was probably due to vesicle destruction leading to drug leakage (Khan et al 2017 ; Zhang et al 2020 ). This trend was also observed by Anbarasan et al ( 2013 ) with capecitabine-loaded niosomes.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery

2021

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Niosomes are increasingly explored for enhancing drug penetration and retention in ocular tissues for both posterior and anterior eye delivery. They have been employed in encapsulating both hydrophilic and hydrophobic drugs, but their use is still plagued with challenges of stability and poor entrapment efficiency particularly with hydrophilic drugs. As a result, focus is on understanding the parameters that affect their stability and their optimization for improved results. Pilocarpine hydrochloride (HCl), a hydrophilic drug is used in the management of intraocular pressure in glaucoma. We aimed at optimizing pilocarpine HCl niosomes and evaluating the effect of sonication on its stability-indicating properties such as particle size, polydispersity index (PDI), zeta potential and entrapment efficiency. Pilocarpine niosomes were prepared by ether injection method. Composition concentrations were varied and the effects of these variations on niosomal properties were evaluated. The effects of sonication on niosomes were determined by sonicating optimized drug-loaded formulations for 30 min and 60 min. Tween 60 was confirmed to be more suitable over Span 60 for encapsulating hydrophilic drugs, resulting in the highest entrapment efficiency (EE) and better polydispersity and particle size indices. Optimum sonication duration as a process variable was determined to be 30 min which increased EE from 24.5% to 42% and zeta potential from (−)14.39 ± 8.55 mV to (−)18.92 ± 7.53 mV. In addition to selecting the appropriate surfactants and varying product composition concentrations, optimizing sonication parameters can be used to fine-tune niosomal properties to those most desirable for extended eye retainment and maintenance of long term stability.

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Section: Discussionsupporting

confidence: 83%

Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery

2021

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“…Z‐potential reflects the surface charge of particles and is an important indicator of the stability of colloidal dispersion systems. A higher absolute Z‐potential indicates that the particles have a larger repulsion force and are not easy to aggregate and settle, thus the stability of the nano‐preparation is better (Zhang, Jing, et al., 2020). Also, PDI is used to describe the inhomogeneity of particle size distribution.…”

Section: Discussionmentioning

confidence: 99%

Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A‐loaded liposomes

Liu

Zhu

Yang

et al. 2021

Journal of Food Biochemistry

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A liposome of Licochalcone A (LCA‐Liposomes) was purposively prepared to ameliorate the low in vivo availability and efficacy of LCA. Physical characterization of LCA‐Liposomes was carried out mainly by determining particle size, morphology, zeta potential (Z‐potential), and efficiency of LCA encapsulation (EE) via appropriate techniques. Also, the rate of LCA release in vitro and distribution in vivo (plasma and tissues) was evaluated. Evaluation of the antirenal activity of LCA‐liposomes was carried out by establishing chronic renal failure (CRF) model in mice through intragastric administration of adenine (200 mg/kg) and subsequent determination of biochemical parameters and examination of tissue sections. Respectively, the mean size of liposomal particles, Z‐potential and EE of LCA‐Liposomes were 71.78 ± 0.99 nm, −38.49 ± 0.06 mV, and 97.67 ± 1.72%. Pharmacokinetic and tissue distribution studies showed that LCA‐Liposomes could improve the availability of LCA in the blood and tissues, whereas during pharmacodynamics studies, the liposome effectively improved the therapeutic effect of LCA on CRF mice by potentially protecting the renal tissues while exhibiting antioxidant activity. In conclusion, LCA‐Liposomes could effectively improve the bioavailability of LCA and provide platform for the development of LCA‐related functional products. Practical applications As a traditional Chinese medicine, licorice is widely used in food and pharmaceutical industries. LCA is a small molecule flavonoid extracted from the root of licorice. In this study, LCA was loaded on liposome carriers, which significantly improved the water solubility and oral bioavailability, and proved that LCA‐Liposomes have certain therapeutic effects on chronic renal failure, thereby providing a basis for the development of LCA into drugs or functional food in the future.

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“…Hence, niosomes can be used for incorporating both polar and nonpolar compounds [134]. Niosome systems have been reported to enhance the transdermal delivery of salidroside [135], sulfadiazine [136], capsaicin [137], resveratrol [138], atenolol [139] and sumatriptan [140].…”

Section: Vesicles and Analoguesmentioning

confidence: 99%

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Ramadon

McCrudden

Courtenay

et al. 2021

Drug Deliv. and Transl. Res.

246

159

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Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

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Sodium dodecyl sulfate improved stability and transdermal delivery of salidroside-encapsulated niosomes via effects on zeta potential

Cited by 54 publications

References 25 publications

Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery

Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery

Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A‐loaded liposomes

Enhancement strategies for transdermal drug delivery systems: current trends and applications

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