Sodium Diuresis from Amphenone Given to Patients with Cirrhosis and Ascites

Aldosterone Antagonism by 17-Spirolactosteroids

“…13 It is too toxic for clinical use but it may increase urinary sodium loss in some patients with oedema. 25,34,40 These new synthetic steroids are characterised chemically by having a spirolactone grouping attached to the 17th carbon atom of the cyclopentenophenanthrene system wvhich forms the basic steroid nucleus (Fig. i).…”