Sodium dithionite initiated reactions of Halothane® with enol ethers

Sodium dithionite initiated addition of 1-bromo-1-chloro-2,2,2-trifluoroethane to β-pinene

“…In most of the published works, including our earlier studies of the reactions of CF 3 CHClBr with enol ethers [6,7], equimolar amounts of the initiator and a perhaloalkane were reported to be necessary to achieve good yields. However, in the present case, as little as 0.25 equivalent of Na 2 S 2 O 4 was found to be satisfactory.…”

“…In the preceding papers [6][7][8], we reported that sulfinatodehalogenation procedure could be applied to 1-bromo-1-chloro-2,2,2-trifluoroethane, commercially available as Halothane 1 (inhalation anaesthetic), to generate CF 3 CHCl . radicals which readily reacted with vinyl ethers [6,7] and with pyrroles [8].…”

Chlorodifluoromethyl-substituted monosaccharide derivatives—radical activation of the carbon–chlorine-bond

“…As radical intermediates are involved in the sodium dithionitemediated fluoroalkylations of unsaturated substrates, 16,17 transformations of unsaturated carbohydrates lead to different by-products. Thus, 3,4-di-O-acetyl-D D-xylal reacted with BrCF 2 Cl to give 3,4-di-O-acetyl-2-C-chlorodifluoromethyl-2-deoxy-D D-xylopyranose in an isolated yield of 54%, in addition to some unidentified by-products.…”

Modified natural substances—fluorinated and fluoroalkylated monosaccharides and inositols

“…The radical addition of 1-halogeno-perfluoroalkanes to p-bonds using sodium dithionite as an initiator is one of the most convenient methods to link perfluoroalkyl chains to organic substrates [42][43][44]; for other methods of initiation see ref. [45][46][47] and papers cited therein.…”