Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity
Dominik Soll,
Mahima Arunkumar,
Maha Alissa-Alkhalaf
et al.
Abstract:Adoptive T-cell therapy has become a powerful weapon for cancer treatment. The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is highly sensitive to the tumor microenvironment. It is therefore of considerable interest to bypass immunosuppressive signals in the tumor microenvironment and to identify factors that augment cytotoxic effector functions and ultimately tumor killing. Whether ionic signals serve as aberrant immune signals and influence the adaptive hu… Show more
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