Sodium chloride and water transport in the descending limb of Henle

Kokko, Juha P.

doi:10.1172/jci106401

Cited by 168 publications

(58 citation statements)

References 18 publications

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“…This prediction is consistent with the experimental findings of Kokko (1970). The decrease of flow rate in the DLH occurs principally in the outer medulla, whereas urea entry takes place along the inner medulla.…”

Section: Loop Of Henlesupporting

confidence: 92%

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Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

1983

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Abstract.A differential equation model of the renal countercurrent system has been developed and physiological data from nephron segments were incorporated together with recently suggested urea recycling from renal pelvis to inner medulla and, particularly, an exponential reduction in the number of collecting tubules towards the renal papilla. The role of these features for the countercurrent concentrating mechanism has been studied by simulation runs. The computations, using the multiple shooting method, provide predictions about concentration profiles for salt and urea in tubes (nephron segments) and in the central core along the entire medullary countercurrent system. The results indicate that this model, without active salt or urea transport in the inner medulla, yields concentration gradients along the medullary axis compatible with those measured in the tissue.

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Section: Loop Of Henlesupporting

confidence: 92%

“…The thick part of the ascending limb was found to be capable of vigorous active salt transport (Burg and Green, 1973). However, physiological studies in vitro and in vivo have failed to provide indisputable evidence for active transepithelial transport in either descending or thin ascending limbs (Kokko, 1970;Imai and Kokko, 1974).…”

Section: Introductionmentioning

confidence: 99%

Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

1983

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“…Increases in papillary blood flow may wash out the medullary solute gradient, decrease water reabsorption, and inhibit passive reabsorption of sodium and chloride in the thin descending loop of Henle. Previous results indicating that the thin descending loop of Henle of the rabbit is relatively impermeable to electrolytes 24 argue against this view. More recent studies, however, indicate that the thin descending loop of Henle of rodents is highly permeable to sodium, chloride, and potassium.…”

Section: ~9mentioning

confidence: 94%

Pressure-diuresis in volume-expanded rats. Tubular reabsorption in superficial and deep nephrons.

Roman

1988

Hypertension

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SUMMARY Micropuncture experiments were performed in volume-expanded rats to better define the nephron segments in which changes in renal perfusion pressure inhibit tubular reabsorption. Neural influences on the kidney were eliminated by renal denervation, and plasma levels of vasopressin, aldosterone, cortkosterone, and norepinephrine were maintained at fixed levels by i.v. infusion. Fractional excretion of sodium, chloride, and water increased markedly after renal perfusion pressure was elevated from 110 to 150 mm Hg. Renal blood flow, glomerular filtration rate, and single nephron glomerular filtration rate measured from deep and superficial nephrons were unaltered. Reabsorption of chloride and water in the proximal tubule of superficial nephrons decreased by 10% after renal perfusion pressure was elevated and contributed to the pressure-diuretic response. Changes in renal perfusion pressure also altered the reabsorption of water and chloride in juxtamedullary nephrons. The percentage of the filtered water load reaching the tip of the loop of Henle increased from 19.8 ± 2.9 to 38.1 ± 3.0% after renal perfusion pressure was elevated. Chloride delivery rose from 34.

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“…Reports in the literature describe water-and solute-permeable descending limbs in hamsters (8,19), rats (1,3,9), chinchillas (1,2,6), and rabbits (10,13,21). The descending limb of Henle's loop has been found in all species to be water permeable and moderately permeable to NaCl and urea.…”

mentioning

confidence: 99%

Immunomorphometric study of rat renal inner medulla

Mejia

Wade

2002

American Journal of Physiology-Renal Physiology

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We utilized immunofluorescent immunolabeling of renal tissue sections to identify and count tubules at specified depths of the rat renal inner medulla. We used primary antibodies to aquaporin-1 (AQP1; labeling thin descending limbs), aquaporin-2 (AQP2; labeling inner medullary collecting ducts), the rat kidney-specific chloride channel (ClC-K1; labeling thin ascending limbs), and von Willebrand factor (labeling descending vasa recta). Secondary antibodies conjugated to different fluorophores were used, giving up to a three-color display. Labeled structures were then identified and counted. At each level sampled in the inner medulla, many more thin limbs were labeled by ClC-K1 than AQP1. In addition, thin limbs were found to label with antibodies to ClC-K1 on both sides of their hairpin turns. We conclude that the descending thin limbs shift from expressing AQP1 to expressing ClC-K1 some distance before the point where they turn and begin to ascend. Mathematical models can use our quantitative data to explore implications for the urine-concentrating mechanism.

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Sodium chloride and water transport in the descending limb of Henle

Cited by 168 publications

References 18 publications

Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

Pressure-diuresis in volume-expanded rats. Tubular reabsorption in superficial and deep nephrons.

Immunomorphometric study of rat renal inner medulla

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