Sodium Chlorate Poisoning

Oliver, J.S.; Smith, Hamilton; Watson, Alan

doi:10.1016/s0015-7368(72)70711-2

Cited by 11 publications

(22 citation statements)

References 1 publication

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“…, 2000), including the current study; and chlorate is found in urine, in the current study (Smith et al. , 2005a), and in many cases cited in the literature (Witthaus, 1911; Ross, 1925; Holzer & Stöhr, 1950; Jansen & Zeldenrust, 1972; Oliver et al. , 1972; Smith et al.…”

Section: Discussionsupporting

confidence: 57%

“…, 2000). At necropsy, affected individuals typically have a brownish discoloration of muscle tissues and organs (Jansen & Zeldenrust, 1972; Oliver et al. , 1972; Cunningham, 1982).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, chlorate, even when not specifically identified, demonstrates its presence in blood through the formation of methemoglobin (Witthaus, 1911; Ansbacher, 1931; Gettler & St George, 1935; Timperman & Maes, 1966; Lee et al. , 1970; Oliver et al. , 1972; Eysseric et al.…”

Section: Discussionmentioning

confidence: 99%

“…, 2000). There is some evidence that chlorate is chemically reduced in the blood by interaction with red blood cells and/or hemoglobin (Oliver et al. , 1972; Abdel‐Rahman et al.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics of ruminally dosed sodium [³⁶Cl]chlorate in beef cattle

Oliver

Craigmill

Caton

et al. 2007

Vet Pharm & Therapeutics

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The recently recognized potential of sodium chlorate as a possible preharvest food safety tool for pathogen reduction in meat animals has spurred interest in the pharmacokinetics of intraruminally dosed chlorate. Six Loala cattle were assigned (one heifer and one steer per treatment) to one of three intraruminal doses of radiolabeled sodium [36Cl]chlorate (21, 42, or 63 mg/kg body weight) administered in four equal aliquots over a 24-h period. Blood and serum were collected (29 samples in 48 h). Total radioactive residues were measured and the radioactive moieties were speciated. Chlorate appeared rapidly in blood and serum after dosing. For animals administered a dose of 42 or 63 mg/kg, the half-life of absorption was estimated at 0.6-0.9 h. Serum chlorate concentrations progressively increased with aliquot administration until peaking at 6-21 parts per million at 26 h. Between aliquot administrations, serum chlorate levels typically peaked in 3.5 h or less. The half-life of chlorate elimination ranged between 6.9 and 11 h, depending on the dose. Ultimately, absorption of chlorate removes it from its desired site of action, the lower gastrointestinal tract, thereby reducing its efficacy. Further research is needed to develop a chlorate formulation that will allow passage to the lower gastrointestinal tract.

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Section: Discussionsupporting

confidence: 57%

“…, 2000). At necropsy, affected individuals typically have a brownish discoloration of muscle tissues and organs (Jansen & Zeldenrust, 1972; Oliver et al. , 1972; Cunningham, 1982).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…, 2000). There is some evidence that chlorate is chemically reduced in the blood by interaction with red blood cells and/or hemoglobin (Oliver et al. , 1972; Abdel‐Rahman et al.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics of ruminally dosed sodium [³⁶Cl]chlorate in beef cattle

Oliver

Craigmill

Caton

et al. 2007

Vet Pharm & Therapeutics

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“…Moreover, the better res lution and recognition of urinary proteins in the two-dimensional pattern permits the identification of fufther patho-> genetic aspects of proteinuria s demomstrated by following examples: 2) was obtained from a 30-year-old woman, 10 days after an intoxication by sodium chlorate. As reported (14), this substance causes tubular injuries. At the time of the analysis the kidney funetion was improved (serum creatinine 130 μπιοΐ/ΐ).…”

Section: Resultsmentioning

confidence: 58%

A Practicable Two-Dimensional Electrophoretic Method for Routine Analysis of Urinary Proteins

Lapin¹

1989

Clinical Chemistry and Laboratory Medicine

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A two dimensional electrophoretic method is described for the routine clinical analysis of urinary proteins. Cellulose acetate electrophoresis is used for the first dimension, and SDS (sodium dodecyl sulphate) electrophoresis for the second dimension, the latter being performed together with gel staining (Coomassie Blue) on the "Phast System". The Separation media are supplied äs "ready-to-use" materials. The method is reliable and reproducible, and is complete within 100 minutes. The resulting two-dimensional pattern of major proteinuria contituents is evaluated visually from the distribution according to molecular weight (second dimension) and from the five zone pattern of cellulose acetate electrophoresis (first dimension). Certain "marker" proteins specific for certain pathological changes, äs well äs certain characteristic changes in protein spot constellation, can be more easily recognized and evaluated than in one-dimensional SDS electrophoresis.

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Diagnostic use of an analysis of urinary proteins by a practicable sodium dodecyl sulfate‐electrophoresis method and rapid two‐dimensional electrophoresis

Lapin

Gabl²,

Kopsa

1989

Electrophoresis

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Two methods suitable for routine clinical analyses of urinary proteins are presented and compared. The first is a horizontal sodium dodecyl sulfate-polyacrylamide gel electrophoresis technique, suitable for simultaneous analysis of 20 native urinary samples. This method uses polyacrylamide gradient gels, prepared with a laboratory-built gel casting device. The second method is a rapid two-dimensional electrophoresis procedure, combining cellulose acetate electrophoresis and sodium dodecyl sulfate-electrophoresis. The first step uses a routine system (Chemetron), the second separation step followed by staining with Coomassie Brilliant Blue R is performed on the PhastSystem. The resulting two-dimensional patterns reveal urinary proteins distributed according to the 5-zone pattern of native proteins (albumin, alpha-1, alpha-2, beta, gamma-globulin) as well as to the logarithm of their molecular weights. Examples of (routine) diagnoses with a special interest in the monitoring of kidney transplant patients are shown.

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Sodium Chlorate Poisoning

Cited by 11 publications

References 1 publication

Pharmacokinetics of ruminally dosed sodium [³⁶Cl]chlorate in beef cattle

Pharmacokinetics of ruminally dosed sodium [³⁶Cl]chlorate in beef cattle

A Practicable Two-Dimensional Electrophoretic Method for Routine Analysis of Urinary Proteins

Diagnostic use of an analysis of urinary proteins by a practicable sodium dodecyl sulfate‐electrophoresis method and rapid two‐dimensional electrophoresis

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Sodium Chlorate Poisoning

Cited by 11 publications

References 1 publication

Pharmacokinetics of ruminally dosed sodium [36Cl]chlorate in beef cattle

Pharmacokinetics of ruminally dosed sodium [36Cl]chlorate in beef cattle

A Practicable Two-Dimensional Electrophoretic Method for Routine Analysis of Urinary Proteins

Diagnostic use of an analysis of urinary proteins by a practicable sodium dodecyl sulfate‐electrophoresis method and rapid two‐dimensional electrophoresis

Contact Info

Product

Resources

About

Pharmacokinetics of ruminally dosed sodium [³⁶Cl]chlorate in beef cattle

Pharmacokinetics of ruminally dosed sodium [³⁶Cl]chlorate in beef cattle