Sodium???Calcium Balance and Cardiac Function with Isotonic Iodixanol

Jynge, Per; Holten, T; An, Oksendal

doi:10.1097/00004424-199301000-00007

Cited by 34 publications

(9 citation statements)

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“…This is made possible by using a dimeric, nonionic molecule like iodixanol, that at clinically relevant concentrations gives a hypotonic solution. Iodixanol solutions are made iso-osmolar by adding sodium and calcium in amounts that have minimal cardiac influence, based on results from animal experiments [19]. Studies in dogs showed that iodixanol caused less extensive cardiac side-effects than both the ionic agent ioxaglate and the nonionic agent iohexol, even when injected in dogs with heart failure [20].…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Bergstra

Dijk

Brekke³

et al. 2000

Cathet. Cardiovasc. Intervent.

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A crossover study was performed to compare the hemodynamic effects of the iso-osmolar contrast agent iodixanol (Visipaque) 320 mg I/ml to those of the low-osmolar iohexol (Omnipaque) 350 mg I/ml. The main hypothesis was that iodixanol and iohexol would affect left ventricular end-diastolic pressure (LVEDP) to different degrees. In 48 patients with reduced cardiac function (mean ejection fraction 33. 4%), one ventricular injection was performed with each contrast medium. Ventricular, aortic and right atrial pressures and heart rate were measured continuously. Cardiac output (using Fick's principle) and systemic vascular resistance were calculated. LVEDP increased with both agents, but significantly less after iodixanol than after iohexol (P < 0.01), also in subgroups of patients in whom baseline LVEDP was severely increased and in whom 3-vessel disease was present. Immediate changes in variables reflecting vasodilatation were similar with both agents. In conclusion, both contrast agents influenced hemodynamics during ventriculography, but iodixanol had significantly less influence on LVEDP than did iohexol.

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Section: Introductionmentioning

confidence: 99%

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Bergstra

Dijk

Brekke³

et al. 2000

Cathet. Cardiovasc. Intervent.

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“…The cytotoxicity of CMs is ameliorated on the basis of the sodium-calcium balance (2,18,19). In the plasma, the Ca 2z /Na z ratio has been estimated to be 0.015 to 0.018 (g/g), which corresponds to 0.009 to 0.010 (mol/mol) (24).…”

Section: Discussionmentioning

confidence: 99%

“…The addition of Ca 2z diminishes the negative inotropic effects of ionic CMs (24). The sodiumcalcium balance seems to reduce the risk of ventricular fibrillation caused by non-ionic CMs (2) and of cardiac contractility depressed by nonionic CMs (19). Free Ca 2z is decreased by ionic CMs, but is affected only negligibly by non-ionic CMs (4).…”

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confidence: 99%

Effect of contrast media on vascular smooth muscle cells

Takatsuki

Furukawa²,

Liu³

et al. 2004

Acta Radiol

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“…The electrolyte composition added to iohexol was based on experiments performed in a Langendorff perfusion model of isolated rabbit heart preparations (2,4,14,24). Addition of plasma concentration levels of sodium to low osmolality CM is known to cause cardiodepression (2,4,24).…”

Section: Discussionmentioning

confidence: 99%

“…However, the amount of sodium needed to prevent VF, in a wedged catheter situation, is small (2,21). Also, studies in isolated perfused hearts have indicated that the cardiodepressive effects of sodium can be counteracted by enriching iohexol with a balanced electrolyte solution (NaCI, CaCl z , MgCl z and KCI) and still maintain a reduced risk of VF (4,14,24).…”

mentioning

confidence: 99%

Cardiac Effects of Adding Electrolytes and Oxygen to Iohexol in a Dog Model of Contrast Media-Induced Ventricular Fibrillation

Jacobsen¹,

Pedersen²,

Kløw³

et al. 1995

Acta Radiol

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We investigated whether addition of a balanced electrolyte supplement and oxygen to the non ionic contrast medium iohexol reduces the risk of ventricular fibrillation (VF), and studied regional electrophysiology prior to the VF event. Twenty ml of each test solution were infused at a rate of 0.5 mils into the left anterior descending coronary artery (LAD) in 8 anesthetized dogs. LAD was externally occluded during infusion, to simulate a wedged catheter situation. ECG, hemodynamics, regional epicardial monophasic action potential duration (MAPD) and ventricular activation times (VAT) were calculated. All infusions with iohexol caused VF within 27 s. Five of 12 infusions with iohexol + 30 mmol NaCI, 3 of 11 infusions with iohexol+electrolytes (IPE) (NaC!, KCI, CaCI 2 and MgCI 2 ) and 4 of II infusions with IPE with oxygen addition (IPE + O 2 ) caused VF after 45 s, Iohexol did not change MAPD prior to the VF event. Iohexol + 30 mmol NaCI and the IPE solutions lengthened MAPD initially, but at the time of the VF event MAPD were normalized or shortened. We conclude that electrolyte supplement to iohexol may prevent VF, probably by lengthening MAPD.

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Sodium???Calcium Balance and Cardiac Function with Isotonic Iodixanol

Cited by 34 publications

References 0 publications

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Effect of contrast media on vascular smooth muscle cells

Cardiac Effects of Adding Electrolytes and Oxygen to Iohexol in a Dog Model of Contrast Media-Induced Ventricular Fibrillation

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