Sodium butyrate supplementation impacts the gastrointestinal bacteria of dairy calves before weaning

Ma, Lu; Yang, Yi; Liu, Wenhui; Bu, Dengpan

doi:10.1007/s00253-023-12485-5

Cited by 7 publications

(9 citation statements)

References 49 publications

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“…Parallel outcomes were recorded in the present study; the group with high SB (HSB) demonstrated a notable variance from the control (CON) group within the beta diversity plot. Similar results were observed in a recent study [ 12 ], which found that a high level of SB supplementation (15, 30, 45 g/d) via milk replacer failed to increase any index related to ruminal microbiota diversity in 42-day-old preweaning dairy calves. We previously established that the optimal dose of exogenous SB supplementation decreased when evaluating the host’s growth phenotype, specifically the average weekly weight gain of the calves [ 11 ].…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies have delved into the impact of exogenous butyrate supplements on the ruminal and intestinal microbiota, typically applied in milk replacer scenarios [ 9 , 12 , 13 ]. In line with these investigations, our recent publication [ 11 ] focused on the near-newborn stage, more precisely day 17, while examining the same parameters.…”

Section: Discussionmentioning

confidence: 99%

“…The role of complementarity and selection mechanisms in shaping the relationship between species richness and some aspects of ecosystem functioning merits future examination [ 23 ]. Ultimately, our findings suggest that low SB supplementation benefits preweaning calves by enhancing richness and potentially increasing their adaptability to external challenges, such as the weaning process [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Supplementing exogenous butyrate in liquid feed for preweaning calves appears to be a reasonable and effective method for ensuring butyrate intake during feeding [ 11 ]. It has been reported that milk replacers introducing exogenous butyrate—such as sodium butyrate (SB), encapsulated variants of SB, and tributyrin [ 9 , 12 , 13 ]—significantly impact the population of key SCFA-producing bacteria, as well as bacteria associated with health in the hindgut. This influence can even extend to the rumen microbiota [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Modulating Gastrointestinal Microbiota in Preweaning Dairy Calves: Dose-Dependent Effects of Milk-Based Sodium Butyrate Supplementation

Wu,

Zhang,

Song

et al. 2024

Microorganisms

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Sodium butyrate (SB), an essential nutritional additive for livestock, has drawn notable interest for its potential for enhancing microbiota development in ruminant animals. This study aimed to assess SB’s effects on ruminal and intestinal microbiota when added to milk for preweaning dairy calves nearing 45 days old. We administered SB in the calves’ milk at four levels: 0 g/d (control), 4.4 g/d (low), 8.8 g/d (medium), and 17.6 g/d (high). After a six-week trial with ten replicates per group, ruminal fluid and fecal samples were collected for 16S rRNA sequencing, specifically targeting the V3–V4 regions to analyze microbiota. The results indicated an enhancement in ruminal microbiota, particularly in community richness, with low-level SB supplementation but minimal benefits from medium and high levels of supplementation. Increasing the level of SB supplementation had a negative impact on intestinal microbiota, affecting community richness and some potentially beneficial bacterial genera. However, low SB supplementation could positively adjust the communication between ruminal and intestinal microbiota. Overall, this study suggests feeding milk supplemented with a low level of SB to suckling calves close to an older age to promote ruminal microbiota development.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modulating Gastrointestinal Microbiota in Preweaning Dairy Calves: Dose-Dependent Effects of Milk-Based Sodium Butyrate Supplementation

Wu,

Zhang,

Song

et al. 2024

Microorganisms

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“…Butyrate, a primary product of intestinal microbial fermentation of dietary fiber, serves as an essential energy source for intestinal epithelial cells and protects colonic epithelial cells from tumorigenesis (Hamer et al, 2008 ; Xu S. et al, 2017 ; Yang and Yu, 2018 ). Ruminococcaceae is a major producer of butyrate, which is dramatically reduced in individuals suffering from inflammatory bowel disease (Darnaud et al, 2018 ; Ma et al, 2023 ). A previous study revealed that MEL effectively ameliorated sleep deprivation-induced colitis by restoring intestinal microbiota homeostasis and improving the production of butyrate (Gao et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Intestinal melatonin levels and gut microbiota homeostasis are independent of the pineal gland in pigs

Zheng,

Zhou,

Zhang

et al. 2024

Front. Microbiol.

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IntroductionMelatonin (MEL) is a crucial neuroendocrine hormone primarily produced by the pineal gland. Pinealectomy (PINX) has been performed on an endogenous MEL deficiency model to investigate the functions of pineal MEL and its relationship with various diseases. However, the effect of PINX on the gastrointestinal tract (GIT) MEL levels and gut microbiome in pigs has not been previously reported.MethodsBy using a newly established pig PINX model, we detected the levels of MEL in the GIT by liquid chromatography–tandem mass spectrometry. In addition, we examined the effects of PINX on the expression of MEL synthesis enzymes, intestinal histomorphology, and the intestinal barrier. Furthermore, 16S rRNA sequencing was performed to analyze the colonic microbiome.ResultsPINX reduced serum MEL levels but did not affect GIT MEL levels. Conversely, MEL supplementation increased MEL levels in the GIT and intestinal contents. Neither PINX nor MEL supplementation had any effect on weight gain, organ coefficient, serum biochemical indexes, or MEL synthetase arylalkylamine N-acetyltransferase (AANAT) expression in the duodenum, ileum, and colon. Furthermore, no significant differences were observed in the intestinal morphology or intestinal mucosal barrier function due to the treatments. Additionally, 16S rRNA sequencing revealed that PINX had no significant impact on the composition of the intestinal microbiota. Nevertheless, MEL supplementation decreased the abundance of Fibrobacterota and increased the abundance of Actinobacteriota, Desulfobacterota, and Chloroflexi.ConclusionWe demonstrated that synthesis of MEL in the GIT is independent of the pineal gland. PINX had no influence on intestinal MEL level and microbiota composition in pigs, while exogenous MEL alters the structure of the gut microbiota.

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Effect of Chaihu-Shugan-San on functional dyspepsia and gut microbiota: A randomized, double-blind, placebo-controlled trial

Wang,

Jia,

Liu

et al. 2024

Journal of Ethnopharmacology

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Sodium butyrate supplementation impacts the gastrointestinal bacteria of dairy calves before weaning

Cited by 7 publications

References 49 publications

Modulating Gastrointestinal Microbiota in Preweaning Dairy Calves: Dose-Dependent Effects of Milk-Based Sodium Butyrate Supplementation

Modulating Gastrointestinal Microbiota in Preweaning Dairy Calves: Dose-Dependent Effects of Milk-Based Sodium Butyrate Supplementation

Intestinal melatonin levels and gut microbiota homeostasis are independent of the pineal gland in pigs

Effect of Chaihu-Shugan-San on functional dyspepsia and gut microbiota: A randomized, double-blind, placebo-controlled trial

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