Sodium butyrate inhibits planktonic cells and biofilms of Trichosporon spp.

Cordeiro, Rossana de Aguiar; Aguiar, Ana Luiza Ribeiro; Pereira, Vandbergue Santos; Pereira, Lívia Maria Galdino; Portela, Fernando Victor Monteiro; Brilhante, Raimunda Sâmia Nogueira; Camargo, Zoilo Pires de; Sidrim, José Júlio Costa; Castelo-Branco, Débora de Souza Collares Maia; Rocha, Marcos Fábio Gadelha

doi:10.1016/j.micpath.2019.03.013

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…Therefore, in addition to conventional antifungal drugs, the HIV aspartyl protease inhibitors ritonavir (RIT), sodium butyrate (NaBut), and farnesol inhibit planktonic growth, biofilm formation, and proteolytic activity in Trichosporon spp. The present studies reinforce the importance of these new antifungals with broader antibiofilm activity as promising antifungal agents [ 18–20 ]. The patient in case 1 who underwent urinary catheter and renal pelvis catheter irrigation treatment was eventually cured and discharged.…”

Section: Discussionsupporting

confidence: 84%

Urinary Tract Infections Caused by Fluconazole-Resistant Trichosporon japonicum in 2 Kidney Transplant Patients and Analysis of Their Homology

Huang

Chen

et al. 2020

Open Forum Infectious Diseases

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Trichosporon spp. are emerging opportunistic agents that cause systemic diseases and life-threatening disseminated disease in immunocompromised hosts. Trichosporon japonicum is a highly rare cause of invasive trichosporonosis. In this study, we described two cases of urinary tract infection caused by Trichosporon japonicum in kidney transplant patients. Culturing of urine samples yielded bluish green colonies of T. japonicum on Candida chromogenic fungal medium. The isolates were identified as T. japonicum by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI TOF-MS, Autof MS 1000). The identification of T. japonicum was further confirmed by 18S rRNA gene sequencing. In vitro drug susceptibility testing showed that the two strains of T. japonicum were resistant to 5-flucytosine, fluconazole and caspofungin with dose-dependent sensitivity to itraconazole and voriconazole but sensitivity to amphotericin B. The homology of the two T. japonicum strains, as determined by cluster analysis and principal component analysis of MALDI-TOF MS, was approximately 85%, suggesting a common nosocomial origin. The first two case reports of fluconazole-resistant T. japonicum urinary infection in kidney transplant recipients are presented.

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Section: Discussionsupporting

confidence: 84%

Urinary Tract Infections Caused by Fluconazole-Resistant Trichosporon japonicum in 2 Kidney Transplant Patients and Analysis of Their Homology

Huang

Chen

et al. 2020

Open Forum Infectious Diseases

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“…The biomass of some fungi decreased significantly after being treated with sodium butyrate, such as Phomopsis and Trichosporon spp. ( Zhu et al, 2018 ; Cordeiro et al, 2019 ). Therefore, it is speculated that 100μm of sodium butyrate used in this study inhibited the biomass of MG1, which lead to insufficient supply of some important precursors of resveratrol, such as phenylalanine and tyrosine.…”

Section: Resultsmentioning

confidence: 99%

Improvement of the Biosynthesis of Resveratrol in Endophytic Fungus (Alternaria sp. MG1) by the Synergistic Effect of UV Light and Oligomeric Proanthocyanidins

Shi

Zhao

et al. 2021

Front. Microbiol.

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Resveratrol, a natural polyphenol compound with multiple bioactivities, is widely used in food and pharmaceutical industry. Endophytic fungus Alternaria sp. MG1, as a native producer of resveratrol, shows increasing potential application. However, strategies for improvement of the biosynthesis of resveratrol in this species are still scarce. In this study, different elicitors were used to investigate their effect on the biosynthesis of resveratrol in MG1 and the induction mechanism. Ultrasound and sodium butyrate had no effect and slight inhibition on the resveratrol production and related gene expression, respectively. UV radiation and co-culture with Phomopsis sp. XP-8 significantly promoted the biosynthesis of resveratrol with the highest production (240.57μg/l) coming from UV 20min. Co-culture altered the profiles of secondary metabolites in MG1 by promoting and inhibiting the synthesis of stilbene and lignin compounds, respectively, and generating new flavonoids ((+/−)-taxifolin, naringin, and (+)-catechin). Oligomeric proanthocyanidins (OPC) also showed an obviously positive influence, leading to an increase in resveratrol production by 10 to 60%. Two calcium-dependent protein kinases (CDPK) were identified, of which CDPK1 was found to be an important regulatory factor of OPC induction. Synergistic treatment of UV 20min and 100μm OPC increased the production of resveratrol by 70.37% compared to control and finally reached 276.31μg/l.

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“…Sodium butyrate, a histone deacetylase inhibitor, reduced the adhesion, biofilm metabolic activity and biomass of T. asahii and T. inkin [ 68 ]. In addition, this compound inhibited planktonic growth, interfered with the filamentation of these species, affecting adhesion, development and maturation of the biofilm.…”

Section: Resultsmentioning

confidence: 99%

Insight into the Antifungals Used to Address Human Infection Due to Trichosporon Spp.: A Scoping Review

Malacrida

Salci²,

Negri

et al. 2021

Future Microbiol.

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Trichosporonosis infections have been increasing worldwide. Providing adequate treatment for these infections remains a challenge. This scoping review contains information about potential antifungals to treat this pathology. Using online databases, we found 76 articles published between 2010 and 2020 related to this topic. Classic antifungals, molecules and biomolecules, repositioned drugs and natural products have been tested against species of Trichosporon. Experimental research has lacked depth or was limited to in vitro and in vivo tests, so there are no promising new candidates for the clinical treatment of patients with trichosporonosis. Furthermore, most studies did not present appropriate scientific criteria for drug tests, compromising their quality.

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Sodium butyrate inhibits planktonic cells and biofilms of Trichosporon spp.

Cited by 16 publications

References 29 publications

Urinary Tract Infections Caused by Fluconazole-Resistant Trichosporon japonicum in 2 Kidney Transplant Patients and Analysis of Their Homology

Urinary Tract Infections Caused by Fluconazole-Resistant Trichosporon japonicum in 2 Kidney Transplant Patients and Analysis of Their Homology

Improvement of the Biosynthesis of Resveratrol in Endophytic Fungus (Alternaria sp. MG1) by the Synergistic Effect of UV Light and Oligomeric Proanthocyanidins

Insight into the Antifungals Used to Address Human Infection Due to Trichosporon Spp.: A Scoping Review

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