Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β

Liu, Huahuan; Bian, Zhongbo; Zhang, Qiuyu; Zhang, Xiao; Cao, Yu; Sun, Xiaodie; Qin, Yong; Mao, Lianzhi; Chu, Xinwei; Liao, Wenzhen; Zha, Longying; Sun, Song

doi:10.1016/j.jff.2021.104862

Cited by 10 publications

(7 citation statements)

References 71 publications

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“…[ 55 ] Moreover, sodium butyrate ameliorated colitis and colitis‐related cancers by attenuating NLRP3 and IL‐1β expression and modulating gut microbiota. [ 56 ] Our findings suggested that SCFAs inhibited the overactivation of NLRP3 inflammasome. Further researches should focus on examining the effect of SCFAs on NLRP3 inflammasome.…”

Section: Discussionmentioning

confidence: 74%

Egg Yolk Lipids Alleviated Dextran Sulfate Sodium‐Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota

Xiao,

He,

Chen

et al. 2023

Molecular Nutrition Food Res

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The increasing incidence of inflammatory bowel disease (IBD) has become a global phenomenon. Egg yolk lipids are one of the essential dietary foods, but its effects on intestinal immunity remain unclear. Here, egg yolk lipids are obtained using ethanol extraction and a total of 601 kinds of lipids are detected via lipidomics, including 251 kinds of triglycerides, 133 kinds of phosphatidylcholines, 44 kinds of phosphatidylethanolamines. Then, the study finds that egg yolk lipids significantly alleviate dextran sulfate sodium‐induced colitis and reduce the production of inflammatory factors. Meanwhile, egg yolk lipids also maintain intestinal barrier integrity and decrease lipopolysaccharide translocation by alleviating intestinal structure damage and increasing the numbers of goblet cells and mucin 2. Mechanistically, egg yolk lipids attenuate colitis by inhibiting the assembly and activation of NLRP3 inflammasome. Moreover, the study also finds that egg yolk lipids reverse gut microbiota dysbiosis referring to increased relative abundance of Bacteroides acidifaciens and decrease relative abundance of Akkermansia muciniphila, as well as increased short chain fatty acids concentration in the gut. Together, the study elucidates the anti‐colitis effect of egg yolk lipids and provides positive evidences for egg yolk lipids involving in dietary strategy and IBD therapy.

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Section: Discussionmentioning

confidence: 74%

Egg Yolk Lipids Alleviated Dextran Sulfate Sodium‐Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota

Xiao,

He,

Chen

et al. 2023

Molecular Nutrition Food Res

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“…However, more authors support the fact that NLRP3 inflammasome with its role in inflammation and tumorigenesis will eventually drive the metastases towards the liver. Due to the overexpression of NLRP3, macrophages will drive up the production of proinflammatory interleukines, which through the macrophage activity will promote cell migration [ 79 , 80 ]. Through a bone-marrow-derived macrophage study (BMDM) in human cancer cells (SW480), a significant increase in cell migration was noted.…”

Section: Resultsmentioning

confidence: 99%

“…Blocking NLRP3 signaling is shown to suppress cell migration. Therefore, macrophages can influence the CRC migration through activation of the NLRP3 inflammasomes, increasing IL-1 β secretion which can ulteriorly be decreased by blocking NLRP3 signaling [ 23 , 79 ]. In addition, a study has shown that the expressions of the macrophage surface marker CD-68 and the proinflammatory cytokine IL-1B are positively correlated.…”

Section: Resultsmentioning

confidence: 99%

The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review

Zaharie

Vălean

Popa

et al. 2023

IJMS

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Colitis-associated colo-rectal cancer remains the leading cause of mortality in inflammatory bowel diseases, with inflammation remaining one of the bridging points between the two pathologies. The NLRP3 inflammasome complex plays an important role in innate immunity; however, its misregulation can be responsible for the apparition of various pathologies such as ulcerative colitis. Our review focuses on the potential pathways of upregulation or downregulation of the NLRP3 complex, in addition to evaluating its role in the current clinical setting. Eighteen studies highlighted the potential pathways of NLRP3 complex regulation as well as its role in the metastatic process in colo-rectal cancer, with promising results. Further research is, however, needed in order to validate the results in a clinical setting.

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“…Liu et al. ( 81 ) revealed that NaB could inhibit colorectal carcinoma. The tumor size was significantly reduced in NaB treated mice groups in comparison to the azoxymethane and dextran sulfate sodium salt (AOM/DSS) mice group.…”

Section: Scfas In Oncological Diseasesmentioning

confidence: 99%

“…The average number of tumor was lower in the case of i.p. NaB application ( 81 ). Previous research revealed that oral intake of NaB inhibit DSS-induced colitis in a mouse model, while i.p.…”

Section: Scfas In Oncological Diseasesmentioning

confidence: 99%

Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review

et al. 2023

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Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of non-digestible carbohydrates in the gastrointestinal tract. They can be seen as the major flow of carbon from the diet, through the microbiome to the host. SCFAs have been reported as important molecules responsible for the regulation of intestinal homeostasis. Moreover, these molecules have a significant impact on the immune system and are able to affect inflammation, cardiovascular diseases, diabetes type II, or oncological diseases. For this purpose, SCFAs could be used as putative biomarkers of various diseases, including cancer. A potential diagnostic value may be offered by analyzing SCFAs with the use of advanced analytical approaches such as gas chromatography (GC), liquid chromatography (LC), or capillary electrophoresis (CE) coupled with mass spectrometry (MS). The presented review summarizes the importance of analyzing SCFAs from clinical and analytical perspective. Current advances in the analysis of SCFAs focused on sample pretreatment, separation strategy, and detection methods are highlighted. Additionally, it also shows potential areas for the development of future diagnostic tools in oncology and other varieties of diseases based on targeted metabolite profiling.

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Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β

Cited by 10 publications

References 71 publications

Egg Yolk Lipids Alleviated Dextran Sulfate Sodium‐Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota

Egg Yolk Lipids Alleviated Dextran Sulfate Sodium‐Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota

The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review

Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review

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