Sodium Butyrate Enhances Intestinal Riboflavin Uptake via Induction of Expression of Riboflavin Transporter-3 (RFVT3)

Subramanian, Veedamali S.; Sabui, Subrata; Heskett, Christopher W; Said, Hamid M.

doi:10.1007/s10620-018-5305-z

Cited by 14 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VB2 is produced by several bacteria, including Lactobacillus, in the gut [43] and hosts express the VB2 transporter in the distal gut [44][45][46][47][48][49]. However, only estimates of VB2 that could be produced and supplied from the gut microbiota to the host are available [50].…”

Section: Discussionmentioning

confidence: 99%

Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice

et al. 2020

View full text Add to dashboard Cite

Microbes in the human gut play a role in the production of bioactive compounds, including some vitamins. Although several studies attempted to identify definitive markers for certain vitamin deficiencies, the role of gut microbiota in these deficiencies is unclear. To investigate the role of gut microbiota in deficiencies of four vitamins, B2, B6, folate, and B12, we conducted a comprehensive analysis of metabolites in mice treated and untreated with antibiotics. We identified glycolate (GA) as a novel marker of vitamin B2 (VB2) deficiency, and show that gut microbiota sense dietary VB2 deficiency and accumulate GA in response. The plasma GA concentration responded to reduced VB2 supply from both the gut microbiota and the diet. These results suggest that GA is a novel marker that can be used to assess whether or not the net supply of VB2 from dietary sources and gut microbiota is sufficient. We also found that gut microbiota can provide short-term compensation for host VB2 deficiency when dietary VB2 is withheld.

show abstract

Section: Discussionmentioning

confidence: 99%

Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Interestingly, a recent study showed that butyrate enhances intestinal B2 uptake demonstrating the crosstalk between host and microbiota in B2 metabolism. [ 47 ]…”

Section: Vitaminsmentioning

confidence: 99%

“…Interestingly, a recent study showed that butyrate enhances intestinal B2 uptake demonstrating the crosstalk between host and microbiota in B2 metabolism. [47] The anti-inflammatory and anti-oxidant potential of B2 and B2producing bacteria was demonstrated in a rodent model for acute colitis. [48] A prospective clinical intervention study in 70 CD patients showed also a clinical improvement, reduction in oxidative stress and several anti-inflammatory effects after 3 weeks of high oral B2 supplementation corresponding to about 100fold RDA, with minimal effects on the composition of the fecal microbiota.…”

Section: Vitamin B2-riboflavinmentioning

confidence: 99%

Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease

Kundra¹,

Rachmühl²,

Lacroix³

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

In patients with inflammatory bowel diseases (IBD), dietary micronutrient intake is low and deficiencies are common. Besides the host, also the gut microbiota require micronutrients and low levels may disturb its functioning. Multi‐omics studies indeed detected shifts in micronutrient‐dependent microbial pathways in IBD. It is however not clear whether micronutrients may alleviate inflammation directly, by modulating the immune system, or also indirectly, by modulating the structure and function of the gut microbiota. The latter seems of particular interest, since the gut microbiota is one of the future therapeutic targets in IBD. A review of the most recent available literature on relevant micronutrients in context of IBD and gut microbiota was conducted. An overview per relevant micronutrient on its role on gut bacterial growth, metabolism and host–microbe interactions during gut inflammation is provided. Dietary micronutrients have potential to be part of future personalized microbiome‐targeted therapies in IBD, considering both the micronutrient status of the host and the gut microbiota. However, cohort studies together with integrated multi‐scale studies are needed to understand the mechanisms of micronutrient–microbiome–host interactions in IBD and to evaluate efficacy and safety of dietary micronutrient treatment strategies.

show abstract

“…Recently, using Caco-2 cells and mouse colonoids, sodium butyrate (NaB) has been demonstrated to up-regulate intestinal Rf uptake inducing the expression of SLC52A3 , possibly due to epigenetics alteration in SLC52A3 promoter after NaB treatment [ 55 ]. Besides its important role as an energetic substrate in intestinal epithelial cells, butyrate is involved in the regulation of immune cell by modulating different processes of intestinal epithelial cells and leukocytes through the activation of G protein-coupled receptors and the modulation of the activity of enzymes and transcription factors including the histone deacetylase [ 56 ].…”

Section: Rf Transportersmentioning

confidence: 99%

“…mRFVT3 is the orthologue of hRFVT3 [ 190 ] and it has been shown to be the main transporter involved in carrier-mediated RF uptake in the native mouse small and large intestine [ 191 ]. Experiments performed on mouse colonoids demonstrated that mRFVT3 is up-regulated both at transcript and protein level after NaB treatment [ 55 ]. Further, it has been shown to be essential for mouse development, with Slc52a3 deficiency resulting in early embryonic lethality associated with defects in placental formation, but dispensable for neural differentiation and short-term maintenance [ 190 ], suggesting that in BVVLS patients with mutations in RFVT3 alternative transporters may act during embryogenesis to allow full-term development.…”

Section: Model Organisms To Study Flavin Homeostasis Alterationsmentioning

confidence: 99%

Development of Novel Experimental Models to Study Flavoproteome Alterations in Human Neuromuscular Diseases: The Effect of Rf Therapy

Tolomeo

Nisco

Leone

et al. 2020

IJMS

View full text Add to dashboard Cite

Inborn errors of Riboflavin (Rf) transport and metabolism have been recently related to severe human neuromuscular disorders, as resulting in profound alteration of human flavoproteome and, therefore, of cellular bioenergetics. This explains why the interest in studying the “flavin world”, a topic which has not been intensively investigated before, has increased much over the last few years. This also prompts basic questions concerning how Rf transporters and FAD (flavin adenine dinucleotide) -forming enzymes work in humans, and how they can create a coordinated network ensuring the maintenance of intracellular flavoproteome. The concept of a coordinated cellular “flavin network”, introduced long ago studying humans suffering for Multiple Acyl-CoA Dehydrogenase Deficiency (MADD), has been, later on, addressed in model organisms and more recently in cell models. In the frame of the underlying relevance of a correct supply of Rf in humans and of a better understanding of the molecular rationale of Rf therapy in patients, this review wants to deal with theories and existing experimental models in the aim to potentiate possible therapeutic interventions in Rf-related neuromuscular diseases.

show abstract

Sodium Butyrate Enhances Intestinal Riboflavin Uptake via Induction of Expression of Riboflavin Transporter-3 (RFVT3)

Cited by 14 publications

References 49 publications

Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice

Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice

Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease

Development of Novel Experimental Models to Study Flavoproteome Alterations in Human Neuromuscular Diseases: The Effect of Rf Therapy

Contact Info

Product

Resources

About