Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp ( Ctenopharyngodon idella )

Wu, Pei; Tian, Li; Zhou, Xiao‐Qiu; Jiang, Wei‐Dan; Liu, Yang; Jiang, Jun; Xie, Fei; Kuang, Sheng‐Yao; Tang, Ling; Tang, Wu‐Neng; Yang, Juan; Zhang, Yongan; Shi, He-Qun; Feng, Lin

doi:10.1016/j.fsi.2017.12.009

Cited by 74 publications

(57 citation statements)

References 69 publications

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“…Except for the main fuels of intestine epithelial cells, pronounced anti‐inflammatory effect of butyrate has been reported in fish species, such as grass carp (Wu et al, ) and turbot (Liu et al, ). The present study indicated that the tributyrin supplementation decreased SBM‐induced pro‐inflammatory response by suppressing suppressor of cytokine signalling 3 (SOCS3), tumour necrosis factor α (TNF‐α) and interleukin 1β (IL1β) gene expression.…”

Section: Discussionmentioning

confidence: 99%

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Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tan

Zhu

et al. 2020

Aquac Res

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Six equal‐protein and equal‐lipid diets were formulated: the fish meal (FM) diet, the soya bean meal (SBM) diet with 40% of FM protein replaced by SBM protein and tributyrin (TB) diets with 0.05% (TB0.05), 0.10% (TB0.1), 0.20% (TB0.2) and 0.40% (TB0.4) tributyrin supplemented in the SBM‐based diet. Each kind of diet was randomly fed to triplicate tanks with 20 fish per tank. Fish were fed apparent satiation twice daily for 56 days. No significant difference in weight gain rate (WGR) and feed efficiency rate (FER) was observed between fish fed the FM, TB0.1 and TB0.2 diets (p > .05). Muscle histidine and arginine proportion of fish fed TB0.1 diet was significantly higher than that of fish fed the SBM diet (p < .05). Intestine morphology results indicated that the supplementation of 0.1% tributyrin significantly improved the mucosal fold height, microvilli length and microvilli density when compared with those of fish fed the SBM diet (p < .05). The supplementation of dietary tributyrin suppressed the pro‐inflammatory gene expression, which may be due to the improvement of physical barrier and modification of microbial communities, such as Acinetobacter, Rhodocyclaceae, Brevundimonas, Sphingopyxis, Hydrogenophaga, Methyloversatilis and Devosia. In conclusion, dietary 0.1% tributyrin supplementation in high‐soya bean meal diet improved growth performance, flesh quality and intestinal morphology structure integrity of yellow drum.

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Section: Discussionmentioning

confidence: 99%

“…Except for the main fuels of intestine epithelial cells, pronounced anti-inflammatory effect of butyrate has been reported in fish species, such as grass carp (Wu et al, 2018) and turbot (Liu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tan

Zhu

et al. 2020

Aquac Res

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“…The Nrf2 identifies the antioxidant response elements (ARE) and induces the transcription of antioxidant enzyme genes, including GPX1 , SOD and CAT (Bae et al, ; Muthusamy et al, ; Wang et al, ). In fish, the gene expression of antioxidant enzymes is also related to Nrf2 signalling pathway and can be regulated by dietary supplement (Tie et al, ; Wu et al, ). Sodium butyrate supplementation up‐regulated these antioxidant enzymes genes ( GPX1 , Cu/Zn‐SOD and CAT ) through Nrf2 signalling in grass intestine (Wu et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…In fish, the gene expression of antioxidant enzymes is also related to Nrf2 signalling pathway and can be regulated by dietary supplement (Tie et al, ; Wu et al, ). Sodium butyrate supplementation up‐regulated these antioxidant enzymes genes ( GPX1 , Cu/Zn‐SOD and CAT ) through Nrf2 signalling in grass intestine (Wu et al, ). Dietary nucleotides enhanced antioxidant enzymes activities and its gene expression, which were modulated by signalling molecules Nrf2 gene and protein expression in grass carp muscle (Tie et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Dietary nano‐selenium enhances antioxidant capacity and hypoxia tolerance of grass carp Ctenopharyngodon idella fed with high‐fat diet

Cheng

Zhang

et al. 2019

Aquacult Nutr

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To evaluate the effects of dietary nano‐selenium (Nano‐Se) on antioxidant capacity and hypoxia tolerance of grass carp fed with high‐fat diet, experimental fishes were fed Nano‐Se supplemented diets at doses of 0 (Control), 0.3, 0.6, 0.9 and 1.2 mg/kg for 10 weeks. After feeding trial, a part of the fishes were exposed to hypoxia stress. Results showed that the survival ratio of grass carp significantly increased in 0.6 and 0.9 mg/kg Nano‐Se group, and the content of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly decreased in 0.6–1.2 mg/kg Nano‐Se groups compared with the control group. In addition, dietary Nano‐Se significantly enhanced glutathione peroxidase (GPX) activity and reduced the malondialdehyde (MDA) content in fishes fed diets with 0.3 and 0.6 mg/kg Nano‐Se. Dietary Nano‐Se significantly elevated mRNA expression of GPX1 and catalase (CAT) by promoting the mRNA expression of NF‐E2‐related nuclear factor 2 (Nrf2) in the hepatopancreas. After hypoxia stress, the GPX and superoxide dismutase (SOD) activities were significantly enhanced, and the MDA content and mortality rate consequently decreased in fishes fed diets with 0.3 and 0.6 mg/kg Nano‐Se. In summary, these results suggested that optimal Nano‐Se in diet enhanced the antioxidant capacity and hypoxia tolerance of grass carp.

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Cellular antioxidant mechanism of mannan‐oligosaccharides involving in enhancing flesh quality in grass carp (Ctenopharyngodon idella)

Lǚ

Jiang

et al. 2022

J Sci Food Agric

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BACKGROUND Deterioration of flesh quality has bad effects on consumer satisfaction. Therefore, effects of safe mannan‐oligosaccharides (MOS) on flesh quality of grass carp (Ctenopharyngodon idella) muscle were studied. A total of 540 healthy fish (215.85 ± 0.30 g) were randomly divided into six groups and fed six separate diets with graded levels of MOS (0, 200, 400, 600, 800 and 1000 mg kg−1) for 60 days. This study aimed at investigating the benefits of dietary MOS on flesh quality (fatty acids, amino acids and physicochemical properties) and the protection mechanism regarding antioxidant status. RESULTS Optimal MOS could improve tenderness (27.4%), pH (5.5%) while decreasing cooking loss (16.6%) to enhance flesh quality. Meanwhile, optimal MOS improved flavor inosine 5′‐monophosphate (IMP) of 11.8%, sweetness and umami‐associated amino acid, healthy unsaturated fatty acid (UFA) of 14.9% and n‐3 polyunsaturated fatty acids (n‐3 PUFAs) especially C20:5n‐3 (15.8%) and C22:6n‐3 (38.3%). Furthermore, the mechanism that MOS affected pH, tenderness and cooking loss could be partly explained by the reduced lactate, cathepsin and oxidation, respectively. The enhanced flesh quality was also associated with enhanced antioxidant ability concerning improving antioxidant enzymes activities and the corresponding transcriptional levels, which were regulated through NF‐E2‐related factor 2 (Nrf2) and target of rapamycin (TOR) signaling. Based on pH24h, cooking loss, shear force and DHA (docosahexaenoic acid, C22:6n‐3), optimal MOS levels for grass carp were estimated to be 442.75, 539.53, 594.73 and 539.53 mg kg−1, respectively. CONCLUSION Dietary MOS is a promising alternative strategy to improve flesh quality of fish muscle. © 2022 Society of Chemical Industry.

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Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp ( Ctenopharyngodon idella )

Cited by 74 publications

References 69 publications

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Dietary nano‐selenium enhances antioxidant capacity and hypoxia tolerance of grass carp Ctenopharyngodon idella fed with high‐fat diet

Cellular antioxidant mechanism of mannan‐oligosaccharides involving in enhancing flesh quality in grass carp (Ctenopharyngodon idella)

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