Sodium–blood pressure interrelationship in pregnancy

Franx, Arie; Steegers, Eric A.P.; Boo, T.M. de; Thien, Th.; Merkus, J.M.W.M.

doi:10.1038/sj.jhh.1000761

Cited by 9 publications

(11 citation statements)

References 29 publications

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“…These women were studied prospectively throughout pregnancy in two related cohort studies, originally designed to evaluate whether dietary sodium restriction has an effect on blood pressure in pregnancy [10,11]. The first study was conducted from 1990 to 1991 in the area of the Maria Hospital, a general teaching hospital in Tilburg, The Netherlands (Tilburg cohort).…”

Section: Patient Populationmentioning

confidence: 99%

Prediction model for hypertension in pregnancy in nulliparous women using information obtained at the first antenatal visit

Nijdam

Janssen²,

Moons³

et al. 2010

Journal of Hypertension

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Objective To develop a prediction model for the occurrence of hypertension in pregnancy using clinical variables obtained routinely at the antenatal booking visit prior to 16 weeks gestation.Methods We studied 2334 nulliparous pregnant women participating in two population-based prospective cohort studies. Potential predictors included maternal age, blood pressure, body weight, height, previous miscarriage and smoking history, assessed at the visit booking prior to 16 weeks gestation. The outcome measure was the development of hypertension before 36 weeks of gestation. A prediction model was derived from the regression model using discrimination, calibration, bootstrapping approaches and transformed into a prediction model usable in clinical practice.Results One hundred and forty-one of 2334 women (6.0%) developed hypertension. Main predictors were systolic and diastolic blood pressure, and weight. The area under the receiver operating characteristic curve of the model was 0.78, 95% confidence interval (CI) 0.75-0.82. Among women with a very low score (19% of the population) the risk of hypertension was 0.5%. In those with a high score (13% of the population) the risk was 22.9%.Conclusion Among nulliparous and initially normotensive women, the use of three simple clinical variables obtained routinely at the antenatal booking visit prior to 16 weeks, can accurately identify women at very low and very high risk of becoming hypertensive before 36 weeks of gestation. When confirmed in recent cohorts, application of the prediction model may lead to a reduction in frequency of antenatal visits for low-risk and increased surveillance for high-risk women.

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Section: Patient Populationmentioning

confidence: 99%

Prediction model for hypertension in pregnancy in nulliparous women using information obtained at the first antenatal visit

Nijdam

Janssen²,

Moons³

et al. 2010

Journal of Hypertension

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“…A prospective study reported that, prior to 32 weeks gestation, no difference could be demonstrated in the association between urinary sodium excretion and arterial pressure in women who remained normotensive and those who became hypertensive. 186 The excretion of a sodium load does not differ significantly between non-pregnant and normotensive pregnant women in the second trimester, but in the third trimester, there is a tendency to sodium retention and expansion of plasma volume under these circumstances. 187 These authors reported that in a prospective study of salt loading in second trimester primigravidae, those who went on to develop GH did not handle a sodium load differently from those who remained normotensive.…”

Section: Renal Functionmentioning

confidence: 99%

Hypertension in pregnancy

Pipkin

Roberts

2000

J Hum Hypertens

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Hypertension arising during pregnancy remains one of the two most frequently-cited causes of maternal death in the UK. In some cases, pregnancy is unmasking underlying hypertension, which manifests itself in later life. Pregnant women who develop de novo proteinuric hypertension (pre-eclampsia, PE) can share many risk factors with patients with the metabolic syndrome, such as obesity, dyslipidaemia and insulin resistance. However, more than half the women who develop PE remain normotensive thereafter. There is a genetic component(s) to the disease, but it is most improbable that there is a 'PE gene'. Rather, there are factors such as geneticallydetermined thrombophilias which are predisposers but not prerequisites. Impaired placentation is a feature, with inadequate invasion of the spiral arteries by syncytiotrophoblast and poor remodelling. However, similiar features are found in association with non-hypertensive

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“…Water balance is controlled by thirst and the secretion of ADH, which are regulated primarily by serum osmolality. In pregnancy the osmotic threshold for ADH release and thirst stimulus is reset down, 14,15 a process which has been interpreted to result from a baroreceptor stimulus from arterial Queensland Diabetes and Endocrine Centre, Mater Misericordiae Hospital, Brisbane, Australia underfilling overwhelming the osmostat. 16 Vasopressinase is released by placental trophoblasts in concentrations proportional to placental weight, so activity is higher in the third trimester or in multiple pregnancies.…”

Section: Renalmentioning

confidence: 99%

Changes in biochemical tests in pregnancy and their clinical significance

Teasdale

Morton

2018

Obstet Med

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Interpretation of laboratory investigations relies on reference intervals. Physiological changes in pregnancy may result in significant changes in normal values for many biochemical assays, and as such results may be misinterpreted as abnormal or mask a pathological state. The aims of this review are as follows: 1. To review the major physiological changes in biochemical tests in normal pregnancy. 2. To outline where these physiological changes are important in interpreting laboratory investigations in pregnancy. 3. To document the most common causes of abnormalities in biochemical tests in pregnancy, as well as important pregnancy-specific causes.

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Sodium–blood pressure interrelationship in pregnancy

Cited by 9 publications

References 29 publications

Prediction model for hypertension in pregnancy in nulliparous women using information obtained at the first antenatal visit

Prediction model for hypertension in pregnancy in nulliparous women using information obtained at the first antenatal visit

Hypertension in pregnancy

Changes in biochemical tests in pregnancy and their clinical significance

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