Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial

Hidratação com bicarbonato de sódio não previne a nefropatia de contraste: ensaio clínico multicêntrico

“…Some of these studies evaluated the use of sodium bicarbonate plus N-acetylcysteine 17,19,21,23 and, therefore, do not allow for a definitive conclusion regarding the benefit of isolated sodium bicarbonate in CIN prophylaxis, once the evaluation of two drugs simultaneously is an important confusion bias. Among studies that compared only sodium bicarbonate and saline solution, the results are also inconsistent 18,20,22 . The present study is the only multicenter and has the largest sample size among the studies that evaluated hydration with bicarbonate as a single approach for CIN prophylaxis.…”

“…Posterior studies evaluated sodium bicarbonate in the prevention of CIN in patients submitted to the angiography and/or PCI produced conflicting results [17][18][19][20][21][22][23] . Some of these studies evaluated the use of sodium bicarbonate plus N-acetylcysteine 17,19,21,23 and, therefore, do not allow for a definitive conclusion regarding the benefit of isolated sodium bicarbonate in CIN prophylaxis, once the evaluation of two drugs simultaneously is an important confusion bias.…”

“…For variables with nonparametric distribution, the Mann-Whitney test was used, data being expressed as median (25 percentile -75 percentile). Sample size was calculated as 298 individuals, to detect a 50% change in the relative risk for CIN associated with the hydration with sodium bicarbonate 16,18 , assuming a 10% incidence of CIN in the group randomized to saline, with a power of 80% and α error of 0.05.…”

“…However, there is limited and controversial data regarding assessing the efficacy of sodium bicarbonate in patients undergoing cardiac catheterization [17][18][19][20][21][22][23] .…”

Prevenção de nefrotoxicidade por contraste com solução de bicarbonato: resultados preliminares e revisão da literatura

“…Hydration with bicarbonate proved to be better regarding the incidence of CN. 58 The other study published was retrospective, and showed a deleterious effect of bicarbonate on CN. That study assessed 7,977 patients undergoing contrast-enhanced exams, ranging from tomographies to cardiac catheterizations.…”