Sodium bicarbonate infusion for prevention of acute kidney injury: No evidence for superior benefit, but risk for harm?

Schiffl, Helmut

doi:10.1007/s11255-014-0820-0

Cited by 18 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sodium bicarbonate is thought to increase the solubility of these products preventing the formation of obstructive methemoglobin cylinders and crystals in the tubules [81]. In addition, sodium bicarbonate is thought to reduce oxidative stress and free radicals [81]. This led to the hope that sodium bicarbonate may prevent AKI.…”

Section: Treatment and Management Of Akimentioning

confidence: 99%

See 1 more Smart Citation

Acute kidney injury—an overview of diagnostic methods and clinical management

Hertzberg¹,

Rydén²,

Pickering³

et al. 2017

Clinical Kidney Journal

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a common condition in multiple clinical settings. Patients with AKI are at an increased risk of death, over both the short and long term, and of accelerated renal impairment. As the condition has become more recognized and definitions more unified, there has been a rapid increase in studies examining AKI across many different clinical settings. This review focuses on the classification, diagnostic methods and clinical management that are available, or promising, for patients with AKI. Furthermore, preventive measures with fluids, acetylcysteine, statins and remote ischemic preconditioning, as well as when dialysis should be initiated in AKI patients are discussed. The classification of AKI includes both changes in serum creatinine concentrations and urine output. Currently, no kidney injury biomarkers are included in the classification of AKI, but proposals have been made to include them as independent diagnostic markers. Treatment of AKI is aimed at addressing the underlying causes of AKI, and at limiting damage and preventing progression. The key principles are: to treat the underlying disease, to optimize fluid balance and optimize hemodynamics, to treat electrolyte disturbances, to discontinue or dose-adjust nephrotoxic drugs and to dose-adjust drugs with renal elimination.

show abstract

Section: Treatment and Management Of Akimentioning

confidence: 99%

“…In prevention of CI-AKI, sodium bicarbonate solutions have not shown to be superior compared with sodium chloride solutions [26]. Thus, sodium bicarbonate is not recommended for the prevention or treatment of AKI currently [81, 85]. …”

Section: Treatment and Management Of Akimentioning

confidence: 99%

Acute kidney injury—an overview of diagnostic methods and clinical management

Hertzberg¹,

Rydén²,

Pickering³

et al. 2017

Clinical Kidney Journal

View full text Add to dashboard Cite

show abstract

“…Results of trials have been inconsistent, and urinary alkalinization is currently not recommended for the prevention of CIN [76].…”

Section: Sodium Bicarbonatementioning

confidence: 99%

Acute kidney injury in cardiac surgery

Gaffney

Sladen

2015

Current Opinion in Anaesthesiology

View full text Add to dashboard Cite

show abstract

“…However, in an assessment of available information, Schiffl concluded that intravenous sodium bicarbonate did not offer any benefit over normal saline. 34 Studies showing superiority of sodium bicarbonate hydration have been published as in the case of the meta-analyses of Meier et al and Jang et al, which reported superiority of hydration with sodium bicarbonate versus normal saline in the prevention of CI-AKI. 35,36 However, the assessment of Hogan et al from a meta-analysis was that any reported superiority of sodium bicarbonate over normal saline in the prevention of CI-AKI is possibly due to study heterogeneity and publication bias.…”

Section: Sodium Bicarbonatementioning

confidence: 99%

Renal Iodine Dye Risk, Age, and the Acute Coronary Syndrome

Whayne

2015

Angiology

View full text Add to dashboard Cite

Sodium bicarbonate infusion for prevention of acute kidney injury: No evidence for superior benefit, but risk for harm?

Cited by 18 publications

References 47 publications

Acute kidney injury—an overview of diagnostic methods and clinical management

Acute kidney injury—an overview of diagnostic methods and clinical management

Acute kidney injury in cardiac surgery

Renal Iodine Dye Risk, Age, and the Acute Coronary Syndrome

Contact Info

Product

Resources

About