Sodium bicarbonate and intracellular acidosis: Myth or reality?

Çuhaci, Bülent; Lee, Jean; Ahmed, Ziauddin

doi:10.1097/00003246-200105000-00049

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…Bicarbonate-induced alkalinization also decreases ionized calcium, and this has the potential to adversely effect excitation-contraction coupling of the myocardium [134]. Finally, one of the strongest arguments against the use of NaHCO 3 is the possibility of paradoxically worsening intracellular acidosis [151,152]. Bicarbonate combines with hydrogen to form H 2 CO 3 , which dissociates into CO 2 and H 2 O.…”

Section: Sodium Bicarbonatementioning

confidence: 99%

Lactic Acidosis: From Sour Milk to Septic Shock

Fall

Szerlip

2005

J Intensive Care Med

167

142

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Lactic acidosis is frequently encountered in the intensive care unit. It occurs when there is an imbalance between production and clearance of lactate. Although lactic acidosis is often associated with a high anion gap and is generally defined as a lactate level >5 mmol/L and a serum pH <7.35, the presence of hypoalbuminemia may mask the anion gap and concomitant alkalosis may raise the pH. The causes of lactic acidosis are traditionally divided into impaired tissue oxygenation (Type A) and disorders in which tissue oxygenation is maintained (Type B). Lactate level is often used as a prognostic indicator and may be predictive of a favorable outcome if it normalizes within 48 hours. The routine measurement of serum lactate, however, should not determine therapeutic interventions. Unfortunately, treatment options remain limited and should be aimed at discontinuation of any offending drugs, treatment of the underlying pathology, and maintenance of organ perfusion. The mainstay of therapy of lactic acidosis remains prevention.

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Section: Sodium Bicarbonatementioning

confidence: 99%

Lactic Acidosis: From Sour Milk to Septic Shock

Fall

Szerlip

2005

J Intensive Care Med

167

142

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“…Bikarbonat infüzyonu kalsiyum, albümin, hidrojen iyonu ile ilişkili olarak intrasellüler pH'nin azalmasına/ekstrasellüler pH'ın artmasına, bohr etkisi ile de hipoksiye yol açabilir. Bikarbonat tedavisi; paradoksal olarak hücre içi asidoza yol açabilir (11). Tamponlama sistemlerinin pH, sağkalım ve hemodinami üzerine etkisini araştırmak için yapılan çalışmalarda birbirlerine üstünlüğü saptanmamıştır (12).…”

Section: Discussionunclassified

Lactic Acidosis: A Short Review of Cases

Sargın¹,

Yavaşoğlu²,

Kadıköylü³

et al. 2011

Yoğun Bakim Derg

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Lactic acidosis, which is caused by a high anion concentration due to metabolic acidosis, occurs when the plasma lactate concentration exceeds 4 to 5 millimoles/litre (mmol/L) (normal range: 0.5-1.5 mmol/L). Lactate accumulation results from increased metabolism or decreased excretion. Lactic acidosis cases often occurs in intensive care units. In order to carry out effective treatment, the primary aim must be the reversal of the causes underlying the disease. Today, various methods are used to treat lactic acidosis. We have reviewed the occurrence of lactic acidosis in two cases in light of the current literature. Lactic acidosis can have quite serious consequences, and clinicians must be very careful while managing patients with lactic acidosis. (Yoğun Bakım Derg 2011; 3: 63-6) Laktik asidoz artmış anyon açıklığı olan metabolik asidoz nedeni olup; plazma laktat konsantrasyonu 4-5 milimol/Litre (mmol/L) (Normal aralık: 0.5-1.5 mmol/L) aştığında oluşur. Laktat birikimi, artmış üretim ya da azalmış atılım metabolizma nedeniyle olmaktadır. Yoğun bakım ünitelerinde sıklıkla laktik asidoz tablosu ile karşılaşmaktayız. Tedavinin etkin olması için öncelikli amaç, altta yatan hastalık sürecinin tersine çevrilmesi olmalıdır. Günümüzde laktik asidoza yönelik olarak değişik tedavi yöntemleri kullanılmaktadır. İki olgu nedeni ile ve literatür verileri ışığında laktik asidoz tarafımızdan tekrardan irdelenmiştir. Laktik asidoz çok ciddi sonuçlara neden olabilmektedir. Klinisyenler laktik asidozlu hastaların yönetiminde çok dikkatli olmalıdır. AbstractÖzet

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“…17 Chez beaucoup de patients, notamment patients obèses, cardiaques, anémiques, l'estimation clinique du volume du secteur extracellulaire est incertaine et peut être aidée par la mesure de la pression veineuse centrale, par des données d'imagerie thoracique ou abdominale (voir ci-après), plus rarement par la mesure isotopique du volume sanguin ou par celle de l'impédance bioélectrique à faible fréquence.…”

Section: Troubles De L'hydratationunclassified

“…17 L'effet stimulant de ces diurétiques sur la sécrétion distale de potassium est probablement double : stimulation de la sécrétion de l'aldostérone en rapport avec la déplétion extracellulaire et volémique ; concentration augmentée de sodium dans le fluide tubulaire distal favorisant les échanges sodium/potassium au niveau du tube collecteur. Dans ces cas, l'hyperaldostéronisme et l'hypokaliémie qu'elle entraîne sont en rapport avec la diminution de la volémie vraie (comme dans certains syndromes néphrotiques), ou de la volémie efficace circulante (comme dans l'insuffisance cardiaque et la cirrhose).…”

Section: Hyperaldostéronisme Secondaireunclassified

Troubles hydroélectrolytiques

Kanfer¹

2014

Néphrologie Et Troubles Hydro-Électriques

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Sodium bicarbonate and intracellular acidosis: Myth or reality?

Cited by 11 publications

References 17 publications

Lactic Acidosis: From Sour Milk to Septic Shock

Lactic Acidosis: From Sour Milk to Septic Shock

Lactic Acidosis: A Short Review of Cases

Troubles hydroélectrolytiques

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