Sodium arsenite toxicity on hematology indices and reproductive parameters in Teddy goat bucks and their amelioration with vitamin C

Zubair, Muhammad; Ahmad, Maqbool; Saleemi, Muhammad Kashif; Gul, Shafia Tehseen; Ahmad, Mushtaq; Martyniuk, Christopher J.; Ullah, Qudrat; Umar, Syed

doi:10.1007/s11356-020-08049-z

Cited by 16 publications

(7 citation statements)

References 32 publications

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“…Sodium arsenate and sodium arsenite administered in rat diet at doses up to 400 and 250 µg/g arsenic, respectively, were negative in 2-year bioassays performed in rats. Administration of arsenite with a dose rate of 5 mg/kg body weight to rats (Jana et al, 2006;Ahmed et al, 2019) and Teddy goat bucks (Zubair et al, 2020) showed significant reduction in the level of testosterone, key hormone for the regulation of spermatogenesis and sexual behavior in the male reproductive system. Arsenite is more deleterious to male fertility than arsenate, and exposure to 10 mg/L arsenite reduced daily sperm production via H2O2 overproduction and germ cells loss in male Wistar rats (Lima et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Spirulina ameliorates arsenic induced reproductive toxicity in male rats

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Spirulina ameliorates arsenic induced reproductive toxicity in male rats

et al. 2021

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“…As level of hormones and arsenic concentration is measured in the blood of infertile males which indicated that the concentration of arsenic and blood luteinizing hormones are strongly negatively correlated. LH can stimulate testosterone production in interstitial cell, the dysfunction or absence of testosterone lead to male infertility [36]. Epidemiological studies revealed that in Taiwan due to drinking of arsenic contaminated water the risk of prostate cancer is 6 times more than other population [37].…”

Section: Effects On Male Fertilitymentioning

confidence: 99%

Reproductive Toxicity of Arsenic: What We Know and What We Need to Know?

Ahmad¹,

Majeed²,

Jabbar³

et al. 2021

Environmental Health

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In the most recent the environmental provident and threatening conduct of arsenic has increased the consideration of the world due to its pollution and hazardous effects throughout the world. Arsenic contamination is serious issue throughout the world and is substantial risk factor in most of countries including China, U.S.A, India, Bangladesh, Mexico and Argentina. Several experimental models have been established to understand the diseases caused by arsenic exposure. However reproductive and developmental toxicity have been poorly understood. The objectives of this study are to discuss current landscapes and future horizons of arsenic toxicity in human and animals in relation to various toxicity routes including oral route involving food and water or through inhalation of agricultural pesticides. Addition of current evidence on the development of destiny and actions of arsenic toxicity in human and animal population and other species will lessen the uncertainties in the hazard assessment for arsenic. This effort would help to protect the public health against the toxic and carcinogenic effects associated with arsenic exposure.

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“…Vitamin C is an antioxidant vitamin, and some studies have reported that vitamin C suppresses the decrease in testosterone associated with testicular toxicity [58,59]. Mohasseb et al reported that the combination of vitamin C and vitamin E suppressed diabetes-induced testosterone decrease in rats through an anti-oxidant effect [60].…”

Section: Vitamin (C/e)mentioning

confidence: 99%

A Review of foods and food supplements increasing testosterone levels

Kataoka¹,

Hotta²,

Kimura³

2021

JOMH

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Androgens are essential for male physical activity. Age-related androgen deﬁciency, known as late-onset hypogonadism (LOH), is considered a risk factor for several diseases. There are many men's health supplements on the market. Therefore, the purpose of this review is to summarize the food ingredients that have been suggested in published literature to increase testosterone levels. A review of previously reported animal studies suggested that 5 representative nutritional components, 7 food ingredients, and 25 supplements were associated with testosterone. Some food and supplements inﬂuence testosterone levels in various animals by directly increasing testosterone or suppressing the decrease in testosterone production due to testicular toxicity. There are three mechanisms by which foods or supplements increase testosterone production: 1) regulating luteinizing hormone, the hormone that stimulates testosterone production, 2) regulating testosterone synthase in the testis, and 3) regulating testosterone-degrading enzymes. In contrast, suppressing the decrease in testosterone depends on the antioxidant effect of the foods. Although detailed mechanistic studies and clinical trials are required to validate these ﬁndings, the use of food to regulate testosterone levels is a promising therapeutic option.

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Sodium arsenite toxicity on hematology indices and reproductive parameters in Teddy goat bucks and their amelioration with vitamin C

Cited by 16 publications

References 32 publications

Spirulina ameliorates arsenic induced reproductive toxicity in male rats

Spirulina ameliorates arsenic induced reproductive toxicity in male rats

Reproductive Toxicity of Arsenic: What We Know and What We Need to Know?

A Review of foods and food supplements increasing testosterone levels

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