Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis in hormone-independent breast cancer cells by regulating apoptotic genes

Li, Shuting; Jiang, Chaowei; Tan, Jingwen; Zhou, Qian; Yin, Jinyao; He, Yuefeng

doi:10.1007/s11356-021-15891-2

Cited by 5 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, even at low doses, arsenic could affect the balance of intracellular processes towards pro- or anticancer effects, depending on breast cancer cell type, time of exposure and many extracellular and intracellular factors [ 61 , 62 ]. Every in vitro study presented in this manuscript provides fragmentary knowledge about a selected process determining arsenic activity in breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…There is a dynamic relationship between mitochondrial function and activity of microRNA (miRNA), a small, noncoding RNA molecule that regulates gene expression at the posttranscriptional level. In breast cancer cells, ATO regulates activity of linear microRNAs such as miR-27a [ 51 ] or let-7a [ 52 ], whereas sodium arsenite upregulates expression of the newly recognized, noncoding circular RNA (circDHX34) in a dose-dependent manner [ 62 ]. Both arsenic compounds upregulate expression levels of antiapoptotic genes BCL2 and BCL2L1 and downregulate expression levels of proapoptotic genes CASP8 and CASP9 , promoting apoptosis in breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Another novel breast cancer biomarkers could be microRNAs, such as miR-27a, serving as a marker of poor prognosis, or let-7a, present in circulation, where its levels correspond with estrogen receptor status and lymph node status [ 51 , 52 ]. The introduction of circDHX34 as a biomarker of exposure to sodium arsenite requires further research [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Breast Cancer and Arsenic Anticancer Effects: Systematic Review of the Experimental Data from In Vitro Studies

Skoczyńska

Skoczyńska²

2022

BioMed Research International

View full text Add to dashboard Cite

Arsenic is a known environmental carcinogenic agent. However, under certain circumstances, it may exert anticancer effects. In this systematic review, we aim to provide information on recent developments in studies on arsenic antitumor effects in breast cancer. Research included in the review refers to experimental data from in vitro studies. The data was collected using search terms “breast cancer,” “arsenic,” and “anticancer” (25.05.2021). Only studies in English and published in the last 10 years were included. The search identified 123 studies from the EBSCOhost, PubMed, and Scopus databases. In the selection process, thirty full-texts were evaluated as eligible for the review. The literature of the last decade provides a lot of information on mechanisms behind anticancer effects of arsenic on breast cancer. Similar to arsenic-induced carcinogenesis, these mechanisms include the activation of the redox system and the increased production of free radicals. Targets of arsenic action are systems of cell membranes, mitochondria, pathways of intracellular transmission, and the genetic apparatus of the cell. Beneficial effects of arsenic use are possible due to significant metabolic differences between cancer and healthy cells. Further efforts are needed in order to establish modes and doses of treatment with arsenic that would provide anticancer activity with minimal toxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Breast Cancer and Arsenic Anticancer Effects: Systematic Review of the Experimental Data from In Vitro Studies

Skoczyńska

Skoczyńska²

2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Circular RNAs (circRNAs) are a major type of non-coding regulatory RNAs that are produced by non-canonical back-splicing events ( Li et al, 2019a ; Liu et al, 2020 ; Ma et al, 2020 ; Li et al, 2021a ; Li et al, 2021b ). CircRNAs are known to modulate gene expression principally via sponging microRNAs (miRNAs) ( Li et al, 2020c ; Pan et al, 2020 ; Ni et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs in Intervertebral Disc Degeneration: An Updated Review

Sun

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

Low back pain, a common medical condition, could result in severe disability and inflict huge economical and public health burden. Its pathogenesis is attributed to multiple etiological factors, including intervertebral disc degeneration (IDD). Emerging evidence suggests that circular RNAs (circRNAs), a major type of regulatory non-coding RNA, play critical roles in cellular processes that are pertinent to IDD development, including nucleus pulposus cell proliferation and apoptosis as well as extracellular matrix deposition. Increasing number of translational studies also indicated that circRNAs could serve as novel biomarkers for the diagnosis of IDD and/or predicting its clinical outcomes. Our review aims to discuss the recent progress in the functions and mechanisms of newly discovered IDD-related circRNAs.

show abstract

“…CircRNAs are newly introduced as regulatory and single-stranded ncRNAs with loop structures produced by non-canonical back-splicing events (39)(40)(41)(42)(43). Some circRNAs mediate their function by interacting with proteins or obstructing mature messenger RNA (mRNA) formation.…”

Section: Introductionmentioning

confidence: 99%

Potential Roles of Circular RNAs and Environmental and Clinical Factors in Intervertebral Disc Degeneration

Malakootian

Gholipour

Moghaddam

et al. 2022

Environ Health Eng Manag

View full text Add to dashboard Cite

Background: Intervertebral disc degeneration (IDD) is a common disability in the working-age population. The underlying pathogenesis of IDD needs elucidation. This study aimed to determine differentially expressed circular RNAs (circRNAs) in IDD by bioinformatics. Additionally, the environmental and clinical factors involved in IDD pathogenesis were reviewed. Methods: The circRNA array profiling of patients with IDD and healthy individuals (GSE67566) was acquired from Gene Expression Omnibus (GEO). GEO2R was employed to analyze the expression profiles of the circRNAs. Functional in silico analysis was done on circRNAs with the highest differential expression. Environmental and clinical factors were reviewed through PubMed and Google Scholar. Results: Twenty-five circRNAs were differentially expressed in IDD. Two circRNAs (hsa_ circRNA_101645 and hsa_circRNA_101852) exhibited the most downregulated and upregulated expressions. The functional in silico analysis showed that the aforementioned circRNAs harbored target sites for AGO2 and EIF4A3 and several microRNAs. The upshots indicated that these 2 circular circRNAs might sponge hsa-miR-330-3p, hsa-miR-502-5p, hsa-miR-662, hsa-miR-874, and hsa-miR-646 and regulate PSD3, SIK2, PCYT1B, ARID5B, MTMR3, and HIPK2 expressions, which play significant roles in autophagy and cellular senescence. Temperature, heavy metal exposure, age, overweight, occupation, exercise, hypertension, and smoking were the environmental and clinical factors associated with IDD progression. Conclusion: Although the results need confirmation by experimental analysis, they reflect the possible role of particular circRNAs in IDD pathogenesis. The controversy concerning the association between IDD and environmental and clinical factors necessitates in-depth population research. Investigating novel molecular regulatory markers like circRNAs could clarify the underlying molecular mechanisms of IDD.

show abstract

Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis in hormone-independent breast cancer cells by regulating apoptotic genes

Cited by 5 publications

References 25 publications

Breast Cancer and Arsenic Anticancer Effects: Systematic Review of the Experimental Data from In Vitro Studies

Breast Cancer and Arsenic Anticancer Effects: Systematic Review of the Experimental Data from In Vitro Studies

Circular RNAs in Intervertebral Disc Degeneration: An Updated Review

Potential Roles of Circular RNAs and Environmental and Clinical Factors in Intervertebral Disc Degeneration

Contact Info

Product

Resources

About