Sodium Arsenite Induced Systemic Organ Damage and Changes in Various Blood Parameters in Mice

Abstract

ABSTRACT:In this study, we examined the toxic effects of arsenic in vivo taking mice as a model animal. Swiss albino mice with similar weights were divided into two groups. The mice belonging to the first group were used as the control, while the other group was exposed to sodium arsenite (SA) through drinking water. Compared to control, the level of hemoglobin in SA-exposed mice was decreased while the number of neutrophils and monocytes were increased. In addition, SA also induced increase in liver and spleen weight within 8 weeks of exposure. In contrast, the weight of the kidney was found to decrease. These findings in mice model might be useful for better understanding of the toxic effects of arsenic in order to develop effective remediation process against arsenicmediated effects on human health.

Bioactive profiling and therapeutic potential of mushroom (Pleurotus tuberregium) extract on Wistar albino rats (Ratus norvegicus) exposed to arsenic and chromium toxicity

“…Similar decrease in RBC number in animal model as well as in human population due to toxicant exposure has been reported by Ref. [ 97 ]. Another possible reason could be that the Cr can cross the red blood cell membrane easily and accumulate in it, thereby leading to DNA protein crosslinking and thus occurrence of anaemia.…”

“…This result is in accordance with that obtained in previous studies by Refs. [ [43] , [97] ]. Decrease in haematological parameters following Cr administration in broiler [ 64 ], rats [ [13] , [63] ] and fish [ 101 ].…”

Effect of arsenic trioxide along with tannic acid, di-sodium hydrogen phosphate, alum and effects of sand-charcoal-iron-filter bed filtrated water along with alum on body weight and some hematological parameters in rabbit

“…However, highly significant (P<0.01) change was observed at 60 days of feeding ( Table-3). The results was in accordance with the findings of Blair et al, (1990);Ferzand et al, (2012); Gyasi et al, (2012) and Sarker et al, (2012). In the same type of studies conducted by Breton et al, (2006) and Gupta and Flora (2006) and they examined the hematological alteration due to arsenic and their results were correlated with our results that TEC and Hb was decreased.…”

“…The results was in accordance with the findings of yeasmin et al, (2011) and Sarker et al, (2012) in mice but dissimilar to the findings of Ferzand et al, (2012); Gyasi et al, 2012 in mice. This might be due to counteract the poisonous effect of arsenic, duration of exposure and dose variability.…”

Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc–Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer

“…For example, stress generated by poisons (eg, the heavy metal arsenic) can increase the blood level of neutrophils in mice. 53 In a study by Haratym-Maj, 54 poisoning of the mice with the low dose of deltamethrin significantly elevated neutrophil levels in blood compared to the control group. Therefore, occurrence of neutrophilia in the AOM-injected oil control is likely to be related to stress from injecting the DNA damaging AOM in mice.…”