Sodium and Potassium Intake: A New Statistical Model to Test Their Effects on Health Outcomes

The Authors Reply

“…We thank Deriaz et al. 1 for their proposal to use a regression model including sodium, potassium, and an interaction term between the two rather than sodium-to-potassium ratio, to determine whether or not this interaction is significant. We repeated our analysis in the CKD-REIN cohort, 2 using a linear model that included spot urinary sodium-to-creatinine (uNa/Cr), potassium-to-creatinine (uK/Cr), and an interaction term to estimate the effect on systolic blood pressure, while adjusting for potential confounders.…”