Sodium and Potassium Concentrations Following Acetazolamide

Changes of Intraocular Pressure and of Chloride, Sodium and Potassium Concentrations in Aqueous Humor and Serum of Rabbits Following Ethanol

“…No alteration of sodium concentrations in the both fluids is obtained after administration of the same drug [4]. Intravenous administration of chloropromazine causes the same ionic changes in AH as those obtained with alcohol ethylic, 25° GL, 3.5 ml/kg i.v.…”

Changes of Intraocular Pressure and of Chloride, Sodium and Potassium Concentrations in Aqueous Humor and Serum of Rabbits Following Chlorpromazine

“…No alteration of the sodium con centrations in the two fluids is obtained after administration of the same drug [Levene, 1958].…”

Glaucoma, 1957-1958

“…The administra¬ tion of these analogs to experimental animals results in no significant alteration in to¬ nographic findings or anterior chamber chemistries.65 These substituted compounds serve as excellent controls for experimental studies.483 Tt is demonstrated and confirmed in a number of laboratories that most methods applied to date for the study of rate of aqueous flow in experimental animals are consistent with some 50% to 60% suppres¬ sion of aqueous formation by all effective carbonic anhydrase inhibitors.65,251"255·800'451, 767.soo -phis includes even such relatively insensitive methods as the turnover of Na24, if posterior chamber, anterior chamber, and plasma concentrations are taken into con¬ sideration at enough time intervals.65 Meas¬ urements of only anterior chamber levels at a few time intervals or at steady state may fail to detect such differences, for they may fall within the experimental error.172·173·234, 319,327,433,437,768,778 Even the reported rise in aqueous humor protein concentration following acetazolam¬ ide can be explained by the decrease in rate of flow with more time in the anterior chamber for diffusional exchange. However, the more potent carbonic anhydrase inhibitors, such as dichlorphenam¬ ide or ethoxzolamide, accomplish this de¬ gree of secretory suppression at lower milligram dose levels.68·282·285·318,594 This is also true for the effects of such agents on the renal tubules of mammals as well as alligators.150,525,628,639 However, with these agents toxicity and side-effects also tend to occur at similarly decreased milligram dose levels.…”