2003
DOI: 10.1007/s00467-003-1178-1
|View full text |Cite
|
Sign up to set email alerts
|

Sodium and potassium clearances by the maturing kidney: clinical-molecular correlates

Abstract: A temporal dissociation exists between the early appearance of sodium absorptive and later detection of potassium secretory processes in the maturing rabbit collecting duct. To extend the latter findings to the human, we sought to correlate developmental changes in renal sodium and potassium clearances with the molecular expression of corresponding ion channels in kidneys of premature infants. In a longitudinal prospective study of 23- to 31-week gestational age (GA) infants, sodium, potassium, and creatinine … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
19
0
5

Year Published

2004
2004
2023
2023

Publication Types

Select...
5
4

Relationship

1
8

Authors

Journals

citations
Cited by 54 publications
(28 citation statements)
references
References 52 publications
1
19
0
5
Order By: Relevance
“…No staining for pendrin was visible in the IMCD (D) or OMCD. Original magnifications ×400-600 secretion increased together with mRNA or protein levels of ROMK or maxi-K channels [10,51].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…No staining for pendrin was visible in the IMCD (D) or OMCD. Original magnifications ×400-600 secretion increased together with mRNA or protein levels of ROMK or maxi-K channels [10,51].…”
Section: Discussionmentioning
confidence: 99%
“…After birth the kidney is not completely matured and excretory and reabsorptive functions are not fully developed as evident from animal models as well as from clinical measurements in newborns and infants [6,10,11,28,51]. In human newborns, small infants and in animal models (with the exception of rabbits) it was noted that plasma HCO 3 − levels and the renal threshold for HCO 3 − are lower [11,38] and that the renal capacity to excrete protons and acid-equivalents is only acquired at a later stage of development [6,7,28].…”
Section: Discussionmentioning
confidence: 99%
“…Although the density of aldosterone binding sites, receptor affinity, and degree of nuclear binding of hormone receptors appear to be similar in mature and immature rats, clearance studies in fetal and newborn animals demonstrate a relative insensitivity of the immature kidney to aldosterone [5,128,129]. This relative hyporesponsiveness is also demonstrated by the observation that the urinary Na + to K + ratio in the newborn typically exceeds 1, despite the fact that both breast milk and commercially available formulas provide Na + to K + in a ratio of 0.5 to 0.6 [4].…”
Section: Mineralocorticoidsmentioning
confidence: 72%
“…34 The urinary fractional excretion of electrolytes is high in neonates and even higher in premature neonates, indicating immature renal tubular function. 35,36 The correlation between uAGT and FENa suggests that the increased uAGT level in neonates might be partially due to renal Figure 2. Correlation between urinary angiotensinogen and urinary sodium/potassium ratio or urinary fractional excretion of sodium (FENa), potassium (FEK) or chloride (FECl).…”
Section: Discussionmentioning
confidence: 99%