Sodium and carbonate distribution in substituted calcium hydroxyapatite

Feki, Hafed El; Savariault, Jean‐Michel; Salah, Abdelhamid Ben; Jemal, M.

doi:10.1016/s1293-2558(00)01059-1

Cited by 71 publications

(64 citation statements)

References 34 publications

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“…Enamel is composed of crystals of hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ], but it is generally defective and contains various other ions. In this study we found that the hydroxyapatite lattice is impure, with carbonate substituting for phosphate [El Feki et al, 2000]. Carbonate is only present up to 3-4 wt% in enamel [Pasteris et al, 2004] but is supposed to be responsible for crystallographic changes in the enamel structure, making it susceptible to acid attack.…”

Section: Color Version Available Onlinementioning

confidence: 73%

Characterizing and Identifying Incipient Carious Lesions in Dental Enamel Using Micro-Raman Spectroscopy

Mohanty

Dadlani²,

Mahoney³

et al. 2012

Caries Res

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Early detection of dental caries is vital if improved patient outcomes are to be achieved by reversal of the demineralization process. Current techniques used by dentists for identifying carious lesions are effective in identifying more advanced lesions, but do not have sufficient sensitivity and specificity to detect them at the earliest stages. This study focused on characterizing the growth of incipient carious lesions in vitro using micro-Raman spectroscopy. The incipient carious lesions were grown on the buccal faces of human molars by controlled exposure to lactic acid. Lesions were cross-sectioned to expose the subsurface body of the lesion and then examined using micro-Raman spectroscopy. The intensity of the phosphate peaks in the Raman spectra was found to differ significantly between healthy enamel and the demineralized region of the lesions. The sensitivity of the phosphate peaks to the degree of demineralization was observed by taking a series of spectra over the cross section of the lesions. This revealed that the body of the lesion is highly demineralized, but in a narrow surface region (up to 10 µm) there is little demineralization. All the phosphate peaks were found to be sensitive to the degree of demineralization; however, changes in the intensity of the pronounced phosphate peak at 961 cm^–1 offer the most promise for identifying lesions. The results indicate that micro-Raman spectroscopy has both the sensitivity and selectivity to identify incipient carious lesions, but the presence of a surface layer with a relatively high mineral content could complicate the analysis.

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Section: Color Version Available Onlinementioning

confidence: 73%

Characterizing and Identifying Incipient Carious Lesions in Dental Enamel Using Micro-Raman Spectroscopy

Mohanty

Dadlani²,

Mahoney³

et al. 2012

Caries Res

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“…The carbonate substitutions in the apatite lattice shift its diffraction peaks, permitting this parameter to be used as a corresponding quantitative indicator [4,13]. Unfortunately, for biogenic apatite the most sensitive (300) line is unsuitable for analysis because of smearing and overlapping.…”

Section: Introductionmentioning

confidence: 99%

Carbonate location in bone tissue mineral by X-ray diffraction and temperature-programmed desorption mass spectrometry

Danilchenko¹,

Pokrovskiy²,

Bogatyrov³

et al. 2005

Cryst. Res. Technol.

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The thermal behavior of bone mineral samples was investigated in the range from 600 to 900ºC by X-ray diffraction with line broadening analysis and temperature-programmed desorption mass spectrometry. At least two stages of CO 3 2-release during the thermal evolution were observed, each can be attributed to a different type of carbonate location in the bone mineral. The elimination of CO 3 2-occurring without pronounced variations in the substructural parameters of the biomineral nanocrystals is ascribed to the surface carbonate, while the elimination of CO 3 2-accompanied by the growth of crystals and disappearance of structural distortions is attributed to the lattice carbonate. The sample of affected immature bone with low bioapatite crystallinity was found to have the surface carbonate content greater than the amount of carbonate in the lattice, while for the mature healthy bone the situation is reverse.

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“…A good straight line of the experimental points for R ≥ 8 evidences the validity of Eq. (10). The experimental points with R, being 4 and 5, are far away from the straight line, which exceed the coexistence boundary of the free water and the bound 3.25 ± 0.1 18.6 ± 0.6 20 3.10 ± 0.1 14.6 ± 0.5 Water 2.80 ± 0.1 11.5 ± 0.4…”

Section: The Molar Enthalpies Of the Reactionmentioning

confidence: 84%

“…The EDS spectrum shown in Fig. 4 indicates the presence of Na element, which is derived from the substitution of Ca 2+ by Na + [10]. The XRD pattern of the product is shown in Fig.…”

Section: The Product Of the Reactionmentioning

confidence: 99%

“…• disappear due to the incorporation of CO V Ca + 3CO 2− 3 + Na + [10,26,27], where V X represents a vacancy on a regular apatite lattice site; thus the proposed chemical formula of the product is Ca 10− 2x 3 [10,26]. The higher limit of 3 corresponds to the theoretical solubility limit of 22.3 wt% of carbonate in HAP [2].…”

Section: The Product Of the Reactionmentioning

confidence: 99%

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Calorimetric investigation of reaction Ca(NO₃)₂ + Na₃PO₄ in water and microemulsions saturated with CO₂

Du¹,

An²,

Fan³

et al. 2011

Int J of Chemical Kinetics

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The reactions of Ca(NO 3 ) 2 + Na 3 PO 4 in water and water/sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/hydrocarbon microemulsions saturated CO 2 with various molar ratios of water to surfactant R, oil phases, and surfactant concentrations were investigated by isothermal titration calorimetry. The product of the reaction was confirmed to be sodium-and-carbonatesubstituted hydroxyapatite (NaCO 3 HAP) by Fourier transform infrared spectra (FTIR), energy dispersive spectrometry (EDS), and X-ray diffraction (XRD). From calorimetric measurements, the molar enthalpies of solution of water in the AOT/n-dodecane system, and the molar enthalpies, the rate constants, and the activation energies of the reactions were determined. It was found that the enthalpy of solution of water in AOT/n-dodecane micells and the molar enthalpy of the reaction in the microemulsions increased with the decreases of R until R = 7; below that they kept almost constant. It may be attributed to the increase of the ratio of the bound water to the free water with the decrease of R until there was no free water when R < 7. However, the reaction rate constant k 1 was affected by the ionic strength of the medium and log k 1 showed a linear dependence on 1/R in the whole range of R we investigated. It was also observed that the rate constant and the enthalpy of the reaction remained almost unchanged when the surfactant concentration and the nature of oil phase varied. C

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Sodium and carbonate distribution in substituted calcium hydroxyapatite

Cited by 71 publications

References 34 publications

Characterizing and Identifying Incipient Carious Lesions in Dental Enamel Using Micro-Raman Spectroscopy

Characterizing and Identifying Incipient Carious Lesions in Dental Enamel Using Micro-Raman Spectroscopy

Carbonate location in bone tissue mineral by X-ray diffraction and temperature-programmed desorption mass spectrometry

Calorimetric investigation of reaction Ca(NO₃)₂ + Na₃PO₄ in water and microemulsions saturated with CO₂

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Sodium and carbonate distribution in substituted calcium hydroxyapatite

Cited by 71 publications

References 34 publications

Characterizing and Identifying Incipient Carious Lesions in Dental Enamel Using Micro-Raman Spectroscopy

Characterizing and Identifying Incipient Carious Lesions in Dental Enamel Using Micro-Raman Spectroscopy

Carbonate location in bone tissue mineral by X-ray diffraction and temperature-programmed desorption mass spectrometry

Calorimetric investigation of reaction Ca(NO3)2 + Na3PO4 in water and microemulsions saturated with CO2

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Calorimetric investigation of reaction Ca(NO₃)₂ + Na₃PO₄ in water and microemulsions saturated with CO₂