Sodium alginate hydrogel containing platelet-rich plasma for wound healing

Wang, Ting; Yi, Wang; Zhang, Yu; Wu, Huayue; Fan, Hengwei; Zhao, Jiulong; Wang, Shige

doi:10.1016/j.colsurfb.2022.113096

Cited by 88 publications

(41 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As far as biomedical applications are concerned, namely drug delivery, tissue engineering, wound dressing, etc. [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ], a specific design of the gelator is needed to meet the requirements of a given application that is among others, biocompatibility, controlled biodegradability, specific functionality, crosslinking density (porosity), reversibility, suitable mechanical properties, injectability and self-healing [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Thermo-Responsive Injectable Hydrogels Formed by Self-Assembly of Alginate-Based Heterograft Copolymers

Safakas

Saravanou

Iatridi

et al. 2023

Gels

View full text Add to dashboard Cite

Polysaccharide-based graft copolymers bearing thermo-responsive grafting chains, exhibiting LCST, have been designed to afford thermo-responsive injectable hydrogels. The good performance of the hydrogel requires control of the critical gelation temperature, Tgel. In the present article, we wish to show an alternative method to tune Tgel using an alginate-based thermo-responsive gelator bearing two kinds of grafting chains (heterograft copolymer topology) of P(NIPAM86-co-NtBAM14) random copolymers and pure PNIPAM, differing in their lower critical solution temperature (LCST) about 10 °C. Interestingly, the Tgel of the heterograft copolymer is controlled from the overall hydrophobic content, NtBAM, of both grafts, implying the formation of blended side chains in the crosslinked nanodomains of the formed network. Rheological investigation of the hydrogel showed excellent responsiveness to temperature and shear. Thus, a combination of shear-thinning and thermo-thickening effects provides the hydrogel with injectability and self-healing properties, making it a good candidate for biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Thermo-Responsive Injectable Hydrogels Formed by Self-Assembly of Alginate-Based Heterograft Copolymers

Safakas

Saravanou

Iatridi

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…A full-thickness defect model was used to assess the healing efficiency of the hydrogels. 52,53 In brief, all rats were randomly divided into 9 groups: control, Alfa (available in the market), AGC, AGC–PPP, AGC–PRP, AGC–PPP–PDA (−NIR), AGC–PRP–PDA (−NIR), AGC–PPP–PDA (+NIR), and AGC–PRP–PDA (+NIR). The rats (male, 180 g) were anesthetized using ketamine/xylazine (6 : 4, v/v), and then 10 mm diameter full-thickness skin round wounds were created after shaving on the dorsal area of the rats.…”

Section: Methodsmentioning

confidence: 99%

Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration

Alinezhad,

Esmaeilzadeh,

Bagheri

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…Hydrogels are prepared from natural or synthetic polymers and have promising applications in the field of hemostatic materials [ 15 , 16 ]. Different natural polymers and their derivatives and synthetic polymers that can be processed into hydrogels are shown in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

et al. 2023

Self Cite

View full text Add to dashboard Cite

The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantageous characteristics compared to traditional hemostatic materials. The effects of the hemostatic mechanism, effects of deacetylation degree, relative molecular mass, and chemical modification on the hemostatic performance of CS hydrogels are summarized. Meanwhile, some typical applications of CS hydrogels are introduced to provide references for the preparation of efficient hemostatic hydrogels. Finally, the future perspectives of CS-based hemostatic hydrogels are presented.

show abstract

Sodium alginate hydrogel containing platelet-rich plasma for wound healing

Cited by 88 publications

References 39 publications

Thermo-Responsive Injectable Hydrogels Formed by Self-Assembly of Alginate-Based Heterograft Copolymers

Thermo-Responsive Injectable Hydrogels Formed by Self-Assembly of Alginate-Based Heterograft Copolymers

Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Contact Info

Product

Resources

About