Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors

Cui, Zhifen; Zhang, Yu; Zhang, Jichao; Kong, Huating; Tang, Xiangming; Pan, Liang; Xia, Kai; Aldalbahi, Ali; Li, Aiguo; Tai, Renzhong; Chen, Fan; Zhu, Ying

doi:10.1016/j.carbon.2015.07.066

Cited by 50 publications

(24 citation statements)

References 43 publications

(42 reference statements)

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“…However, for most biomedical applications including drug delivery, the precise control of their surfaces via functionalization is necessary [ 83 , 84 , 85 , 86 , 87 ]. It has been pointed out that NDs are not used neat but are conjugated with biocompatible polymers and drugs, similarly to previously reported cases with CNTs and GOs focusing on cancer treatment [ 84 , 88 , 89 , 90 , 91 , 92 ].…”

Section: Types Of Nanocarrierssupporting

confidence: 63%

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Sıafaka

Okur

Karavas

et al. 2016

IJMS

156

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Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic–organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the “state of the art” of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.

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Section: Types Of Nanocarrierssupporting

confidence: 63%

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Sıafaka

Okur

Karavas

et al. 2016

IJMS

156

View full text Add to dashboard Cite

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“…Previous studies showed that DOX has been loaded onto GO by physisorption or chemical conjugation with a high DLE 22 . However, for the delivery of cisplatin, although many drug delivery system [50][51][52][53] have been investigated, the DLE was relatively low. Therefore, building a superior carrier for Pt with high DLE has been the primary challenge.…”

Section: Dual-drug Delivery System Possesses High Dle Superior Cell mentioning

confidence: 99%

PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

Pei

Zhu

Gan

et al. 2020

Sci Rep

148

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Due to their high specific surface area, graphene oxide and graphene oxide-base nanoparticles have great potential both in dual-drug delivery and combination chemotherapy. Herein, we developed cisplatin (pt) and doxorubicin (DoX) dual-drug-loaded peGylated nano-graphene oxide (pGo) to facilitate combined chemotherapy in one system. In this study, nano-sized pGO-Pt/DOX ranged around 161.50 nm was fabricated and characterized using zeta-potential, AFM, TEM, Raman, UV-Vis, and FTIR analyses. The drug delivery efficacy of Pt was enhanced through the introduction of pGO, and the final weight ratio of DOX: Pt: pGO was optimized to 0.376: 0.376: 1. In vitro studies revealed that pGO-Pt/ DOX nanoparticles could be effectively delivered into tumor cells, in which they induced prominent cell apoptosis and necrosis and exhibited higher growth inhibition than the single drug delivery system or free drugs. The pGO-Pt/DOX induced the most prominent cancer cell apoptosis and necrosis rate with 18.6%, which was observed almost 2 times higher than that of pGO-Pt or pGO-DOX groups. in the apoptosis and necrotic quadrants In vivo data confirmed that the pGO-Pt/DOX dual-drug delivery system attenuated the toxicity of pt and DoX to normal organs compared to free drugs. the tumor inhibition data, histopathology observations, and immunohistochemical staining confirmed that the dual-drug delivery system presented a better anticancer effect than free drugs. These results clearly indicated that the pGO-Pt/DOX dual-drug delivery system provided the means for combination drug delivery in cancer treatment. To improve the efficacy and reduce side effects of anticancer drugs, nanoparticle drug delivery systems (DDSs) have been widely explored in the past few decades 1. Graphene, one of the most popular nanoparticles, has attracted tremendous attentions in the DDSs field due to its unique physical and chemical properties 2. Graphene is a two-dimensional single layer constituted of sp 2-hybridized carbon, which could supply a excellent drug-load ability with its high specific surface area. As a derivatives of graphene, graphene oxide (GO), which could be detected to have hydroxyl, carbonyl, carboxyl and epoxide functional groups on thesurfaces of each shee 3. The presence of those reactive functional groups imparts GO with excellent aqueous solubility, biocompatibility and multi-functionalities, which is essential for the delivery of anticancer drugs 4. Because of the unique properties of graphene oxide (GO), many efforts have been made to load anticancer drugs onto GO efficiently by either non-covalent or covalent bonds 5. For instance, Dai and colleagues 6 first attached hydrophobic aromatic molecules such as a camptothecin analogue (SN38) to the GO surface. The resulting GO-SN38 complex exhibits enhanced solubility and higher anticancer ability than the original SN38 prodrug does. In our previous study 7 , cisplatin (Pt) was carried by PEG-functionalized GO (pGO), and the as-prepared GO-Pt exhibits improved drug loading efficiency and enhance...

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“…That is rich source of sodium alginate. The other sources of sodium alginate are Ascophyllum nodosum (22-30%) [11], Laminaria Digitata (25-44%) [11], S. baccularia (23.9%), S. binderi (28.7%), S. siliquosum (38.9%), T. conoides (40.5%) [12], Sargassum muticum (13.57 ± 0.13%) [13], Durvillaea Antarctica (30-55%), Durvillaea willana (30-55%) [14], Turbinaria sp (22.69 + 2.12%), Sargassum sp (24.56 + 0.56%) [15], Laminaria Digitata (51.8%) [16], C. implexa (29.15%), and L. variegate (27.57%) [17].…”

Section: Sources Of Sodium Alginatementioning

confidence: 99%

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

et al. 2021

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Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It is the derivative of alginic acid which comprises 1,4-β-d-mannuronic (M) and α-l-guluronic (G) acids and has the chemical formula (NaC6H7O6). It shows water-soluble, non-toxic, biocompatible, biodegradable, and non-immunogenic properties. It had been used for various biomedical applications, among which the most promising are drug delivery, gene delivery, wound dressing, and wound healing. For different biomedical applications, it is used in different forms with the help of new techniques. That is the reason it had been blended with different polymers. In this review article, we present a comprehensive overview of the combinations of sodium alginate with natural and synthetic polymers and their biomedical applications involving delivery systems. All the scientific/technical issues have been addressed, and we have highlighted the recent advancements.

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Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors

Cited by 50 publications

References 43 publications

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

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